CNS endothelial derived extracellular vesicles are biomarkers of active disease in multiple sclerosis

por Mazzucco, Michael, Mannheim, William, Shetty, Samantha V., Linden, Jennifer R.
Publicado 2022

Clostridium perfringens Epsilon Toxin Causes Selective Death of Mature Oligodendrocytes and Central Nervous System Demyelination

por Linden, Jennifer R., Ma, Yinghua, Zhao, Baohua, Harris, Jason Michael, Rumah, Kareem Rashid, Schaeren-Wiemers, Nicole, Vartanian, Timothy
Publicado 2015

Clostridium perfringens Epsilon Toxin Compromises the Blood-Brain Barrier in a Humanized Zebrafish Model

por Adler, Drew, Linden, Jennifer R., Shetty, Samantha V., Ma, Yinghua, Bokori-Brown, Monika, Titball, Richard W., Vartanian, Timothy
Publicado 2019

Clostridium perfringens epsilon toxin induces blood brain barrier permeability via caveolae-dependent transcytosis and requires expression of MAL

por Linden, Jennifer R., Flores, Claudia, Schmidt, Eric F., Uzal, Francisco A., Michel, Adam O., Valenzuela, Marissa, Dobrow, Sebastian, Vartanian, Timothy
Publicado 2019

Clostridium perfringens Epsilon Toxin Binds to and Kills Primary Human Lymphocytes

por Shetty, Samantha V., Mazzucco, Michael R., Winokur, Paige, Haigh, Sylvia V., Rumah, Kareem Rashid, Fischetti, Vincent A., Vartanian, Timothy, Linden, Jennifer R.
Publicado 2023

A Novel Panel of Rabbit Monoclonal Antibodies and Their Diverse Applications Including Inhibition of Clostridium perfringens Epsilon Toxin Oligomerization

por Linden, Jennifer R., Telesford, Kiel, Shetty, Samantha, Winokour, Paige, Haigh, Sylvia, Cahir-McFarland, Ellen, Antognetti, Giovanna, Datta, Abhishek, Wang, Tao, Meier, Werner, Vartanian, Timothy
Publicado 2018

The Myelin and Lymphocyte Protein MAL Is Required for Binding and Activity of Clostridium perfringens ε-Toxin

por Rumah, Kareem Rashid, Ma, Yinghua, Linden, Jennifer R., Oo, Myat Lin, Anrather, Josef, Schaeren-Wiemers, Nicole, Alonso, Miguel A., Fischetti, Vincent A., McClain, Mark S., Vartanian, Timothy
Publicado 2015

Epsilon toxin–producing Clostridium perfringens colonize the multiple sclerosis gut microbiome overcoming CNS immune privilege

por Ma, Yinghua, Sannino, David, Linden, Jennifer R., Haigh, Sylvia, Zhao, Baohua, Grigg, John B., Zumbo, Paul, Dündar, Friederike, Butler, Daniel, Profaci, Caterina P., Telesford, Kiel, Winokur, Paige N., Rumah, Kareem R., Gauthier, Susan A., Fischetti, Vincent A., McClane, Bruce A., Uzal, Francisco A., Zexter, Lily, Mazzucco, Michael, Rudick, Richard, Danko, David, Balmuth, Evan, Nealon, Nancy, Perumal, Jai, Kaunzner, Ulrike, Brito, Ilana L., Chen, Zhengming, Xiang, Jenny Z., Betel, Doron, Daneman, Richard, Sonnenberg, Gregory F., Mason, Christopher E., Vartanian, Timothy
Publicado 2023