Impact of Genetic Variation on Human CaMKK2 Regulation by Ca(2+)-Calmodulin and Multisite Phosphorylation

por O’Brien, Matthew T., Oakhill, Jonathan S., Ling, Naomi X. Y., Langendorf, Christopher G., Hoque, Ashfaqul, Dite, Toby A., Means, Anthony R., Kemp, Bruce E., Scott, John W.
Publicado 2017

Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding

por Langendorf, Christopher G., Ngoei, Kevin R. W., Scott, John W., Ling, Naomi X. Y., Issa, Sam M. A., Gorman, Michael A., Parker, Michael W., Sakamoto, Kei, Oakhill, Jonathan S., Kemp, Bruce E.
Publicado 2016

Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism

por Hoffman, Nolan J., Whitfield, Jamie, Janzen, Natalie R., Belhaj, Mehdi R., Galic, Sandra, Murray-Segal, Lisa, Smiles, William J., Ling, Naomi X.Y., Dite, Toby A., Scott, John W., Oakhill, Jonathan S., Brink, Robert, Kemp, Bruce E., Hawley, John A.
Publicado 2020

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

por Dite, Toby A., Ling, Naomi X. Y., Scott, John W., Hoque, Ashfaqul, Galic, Sandra, Parker, Benjamin L., Ngoei, Kevin R. W., Langendorf, Christopher G., O’Brien, Matthew T., Kundu, Mondira, Viollet, Benoit, Steinberg, Gregory R., Sakamoto, Kei, Kemp, Bruce E., Oakhill, Jonathan S.
Publicado 2017

mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress

por Ling, Naomi X.Y., Kaczmarek, Adrian, Hoque, Ashfaqul, Davie, Elizabeth, Ngoei, Kevin R.W., Morrison, Kaitlin R., Smiles, William J., Forte, Gabriella M., Wang, Tingting, Lie, Shervi, Dite, Toby A., Langendorf, Christopher G., Scott, John W., Oakhill, Jonathan S., Petersen, Janni
Publicado 2020

A novel small molecule inhibitor of human Drp1

por Rosdah, Ayeshah A., Abbott, Belinda M., Langendorf, Christopher G., Deng, Yali, Truong, Jia Q., Waddell, Helen M. M., Ling, Naomi X. Y., Smiles, William J., Delbridge, Lea M. D., Liu, Guei-Sheung, Oakhill, Jonathan S., Lim, Shiang Y., Holien, Jessica K.
Publicado 2022

Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells

por Hoque, Ashfaqul, Sivakumaran, Priyadharshini, Bond, Simon T., Ling, Naomi X. Y., Kong, Anne M., Scott, John W., Bandara, Nadeeka, Hernández, Damián, Liu, Guei-Sheung, Wong, Raymond C. B., Ryan, Michael T., Hausenloy, Derek J., Kemp, Bruce E., Oakhill, Jonathan S., Drew, Brian G., Pébay, Alice, Lim, Shiang Y.
Publicado 2018

Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission

por Kalkhoran, Siavash Beikoghli, Kriston-Vizi, Janos, Hernandez-Resendiz, Sauri, Crespo-Avilan, Gustavo E, Rosdah, Ayeshah A, Lees, Jarmon G, Costa, Joana Rodrigues Simoes Da, Ling, Naomi X Y, Holien, Jessica K, Samangouei, Parisa, Chinda, Kroekkiat, Yap, En Ping, Riquelme, Jaime A, Ketteler, Robin, Yellon, Derek M, Lim, Shiang Y, Hausenloy, Derek J
Publicado 2021

CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle

por Negoita, Florentina, Addinsall, Alex B., Hellberg, Kristina, Bringas, Conchita Fraguas, Hafen, Paul S., Sermersheim, Tyler J., Agerholm, Marianne, Lewis, Christopher T.A., Ahwazi, Danial, Ling, Naomi X.Y., Larsen, Jeppe K., Deshmukh, Atul S., Hossain, Mohammad A., Oakhill, Jonathan S., Ochala, Julien, Brault, Jeffrey J., Sankar, Uma, Drewry, David H., Scott, John W., Witczak, Carol A., Sakamoto, Kei
Publicado 2023

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1-isoforms

por Pinkosky, Stephen L., Scott, John W., Desjardins, Eric M., Smith, Brennan K., Day, Emily A., Ford, Rebecca J., Langendorf, Christopher G., Ling, Naomi X. Y., Nero, Tracy L., Loh, Kim, Galic, Sandra, Hoque, Ashfaqul, Smiles, William J., Ngoei, Kevin R.W., Parker, Michael W., Yan, Yan, Melcher, Karsten, Kemp, Bruce E., Oakhill, Jonathan S., Steinberg, Gregory R.
Publicado 2020

Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator

por Ovens, Ashley J., Gee, Yi Sing, Ling, Naomi X.Y., Yu, Dingyi, Hardee, Justin P., Chung, Jin D., Ngoei, Kevin R.W., Waters, Nicholas J., Hoffman, Nolan J., Scott, John W., Loh, Kim, Spengler, Katrin, Heller, Regine, Parker, Michael W., Lynch, Gordon S., Huang, Fei, Galic, Sandra, Kemp, Bruce E., Baell, Jonathan B., Oakhill, Jonathan S., Langendorf, Christopher G.
Publicado 2022

The myokine meteorin‐like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2

por Lee, Jung Ok, Byun, Won Seok, Kang, Min Ju, Han, Jeong Ah, Moon, Jiyoung, Shin, Min‐Jeong, Lee, Ho Jun, Chung, Ji Hyung, Lee, Jin‐Seok, Son, Chang‐Gue, Song, Kwon‐Ho, Kim, Tae Woo, Lee, Eun‐Soo, Kim, Hong Min, Chung, Choon Hee, Ngoei, Kevin R. W., Ling, Naomi X. Y., Oakhill, Jonathan S., Galic, Sandra, Murray‐Segal, Lisa, Kemp, Bruce E., Kim, Kyoung Min, Lim, Soo, Kim, Hyeon Soo
Publicado 2020