A survey of the kinome pharmacopeia reveals multiple scaffolds and targets for the development of novel anthelmintics

por Knox, Jessica, Joly, Nicolas, Linossi, Edmond M., Carmona-Negrón, José A., Jura, Natalia, Pintard, Lionel, Zuercher, William, Roy, Peter J.
Publicado 2021

Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain

por Estevam, Gabriella O., Linossi, Edmond M., Macdonald, Christian B., Espinoza, Carla A., Michaud, Jennifer M., Coyote-Maestas, Willow, Collisson, Eric A., Jura, Natalia, Fraser, James S.
Publicado 2023

Suppressor of Cytokine Signaling 4 (SOCS4) Protects against Severe Cytokine Storm and Enhances Viral Clearance during Influenza Infection

por Kedzierski, Lukasz, Linossi, Edmond M., Kolesnik, Tatiana B., Day, E. Bridie, Bird, Nicola L., Kile, Benjamin T., Belz, Gabrielle T., Metcalf, Donald, Nicola, Nicos A., Kedzierska, Katherine, Nicholson, Sandra E.
Publicado 2014

Suppressor of Cytokine Signaling (SOCS) 5 Utilises Distinct Domains for Regulation of JAK1 and Interaction with the Adaptor Protein Shc-1

por Linossi, Edmond M., Chandrashekaran, Indu R., Kolesnik, Tatiana B., Murphy, James M., Webb, Andrew I., Willson, Tracy A., Kedzierski, Lukasz, Bullock, Alex N., Babon, Jeffrey J., Norton, Raymond S., Nicola, Nicos A., Nicholson, Sandra E.
Publicado 2013

Author Correction: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands

por Linossi, Edmond M., Li, Kunlun, Veggiani, Gianluca, Tan, Cyrus, Dehkhoda, Farhad, Hockings, Colin, Calleja, Dale J., Keating, Narelle, Feltham, Rebecca, Brooks, Andrew J., Li, Shawn S., Sidhu, Sachdev S., Babon, Jeffrey J., Kershaw, Nadia J., Nicholson, Sandra E.
Publicado 2023

Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands

por Linossi, Edmond M., Li, Kunlun, Veggiani, Gianluca, Tan, Cyrus, Dehkhoda, Farhad, Hockings, Colin, Calleja, Dale J., Keating, Narelle, Feltham, Rebecca, Brooks, Andrew J., Li, Shawn S., Sidhu, Sachdev S., Babon, Jeffrey J., Kershaw, Nadia J., Nicholson, Sandra E.
Publicado 2021

Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling

por Kedzierski, Lukasz, Tate, Michelle D, Hsu, Alan C, Kolesnik, Tatiana B, Linossi, Edmond M, Dagley, Laura, Dong, Zhaoguang, Freeman, Sarah, Infusini, Giuseppe, Starkey, Malcolm R, Bird, Nicola L, Chatfield, Simon M, Babon, Jeffrey J, Huntington, Nicholas, Belz, Gabrielle, Webb, Andrew, Wark, Peter AB, Nicola, Nicos A, Xu, Jianqing, Kedzierska, Katherine, Hansbro, Philip M, Nicholson, Sandra E
Publicado 2017