Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens

por Lippl, Kerstin, Boleininger, Anna, McDonough, Michael A, Abboud, Martine I, Tarhonskaya, Hanna, Chowdhury, Rasheduzzaman, Loenarz, Christoph, Schofield, Christopher J
Publicado 2018

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors

por Holt-Martyn, James P., Tumber, Anthony, Rahman, Mohammed Z., Lippl, Kerstin, Figg, William, McDonough, Michael A., Chowdhury, Rasheduzzaman, Schofield, Christopher J.
Publicado 2019

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases

por Chan, Mun Chiang, Ilott, Nicholas E., Schödel, Johannes, Sims, David, Tumber, Anthony, Lippl, Kerstin, Mole, David R., Pugh, Christopher W., Ratcliffe, Peter J., Ponting, Chris P., Schofield, Christopher J.
Publicado 2016

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

por Cockman, Matthew E, Lippl, Kerstin, Tian, Ya-Min, Pegg, Hamish B, Figg, William D, Abboud, Martine I, Heilig, Raphael, Fischer, Roman, Myllyharju, Johanna, Schofield, Christopher J, Ratcliffe, Peter J
Publicado 2019

Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii

por Liu, Tongri, Abboud, Martine I., Chowdhury, Rasheduzzaman, Tumber, Anthony, Hardy, Adam P., Lippl, Kerstin, Lohans, Christopher T., Pires, Elisabete, Wickens, James, McDonough, Michael A., West, Christopher M., Schofield, Christopher J.
Publicado 2021

2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2

por Abboud, Martine I., McAllister, Tom E., Leung, Ivanhoe K. H., Chowdhury, Rasheduzzaman, Jorgensen, Christian, Domene, Carmen, Mecinović, Jasmin, Lippl, Kerstin, Hancock, Rebecca L., Hopkinson, Richard J., Kawamura, Akane, Claridge, Timothy D. W., Schofield, Christopher J.
Publicado 2018

Structure‐Activity Relationship and Crystallographic Studies on 4‐Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors

por Holt‐Martyn, James P., Chowdhury, Rasheduzzaman, Tumber, Anthony, Yeh, Tzu‐Lan, Abboud, Martine I., Lippl, Kerstin, Lohans, Christopher T., Langley, Gareth W., Figg, William, McDonough, Michael A., Pugh, Christopher W., Ratcliffe, Peter J., Schofield, Christopher J.
Publicado 2019

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

por Yeh, Tzu-Lan, Leissing, Thomas M., Abboud, Martine I., Thinnes, Cyrille C., Atasoylu, Onur, Holt-Martyn, James P., Zhang, Dong, Tumber, Anthony, Lippl, Kerstin, Lohans, Christopher T., Leung, Ivanhoe K. H., Morcrette, Helen, Clifton, Ian J., Claridge, Timothy D. W., Kawamura, Akane, Flashman, Emily, Lu, Xin, Ratcliffe, Peter J., Chowdhury, Rasheduzzaman, Pugh, Christopher W., Schofield, Christopher J.
Publicado 2017