Recent advances in understanding NRF2 as a druggable target: development of pro-electrophilic and non-covalent NRF2 activators to overcome systemic side effects of electrophilic dr...

por Satoh, Takumi, Lipton, Stuart
Publicado 2017

Redox regulation of mitochondrial fission, protein misfolding, synaptic damage, and neuronal cell death: potential implications for Alzheimer’s and Parkinson’s diseases

por Nakamura, Tomohiro, Lipton, Stuart A.
Publicado 2010

Dysfunctional Mitochondrial Dynamics in the Pathophysiology of Neurodegenerative Diseases

por Haun, Florian, Nakamura, Tomohiro, Lipton, Stuart A
Publicado 2013

Emerging hiPSC Models for Drug Discovery in Neurodegenerative Diseases

por Trudler, Dorit, Ghatak, Swagata, Lipton, Stuart A.
Publicado 2021

Aberrant protein S-nitrosylation contributes to hyperexcitability-induced synaptic damage in Alzheimer’s disease: Mechanistic insights and potential therapies

por Ghatak, Swagata, Nakamura, Tomohiro, Lipton, Stuart A.
Publicado 2023

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

por Tu, Shichun, Okamoto, Shu-ichi, Lipton, Stuart A, Xu, Huaxi
Publicado 2014

Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer’s Disease, Parkinson’s Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Infla...

por Satoh, Takumi, Trudler, Dorit, Oh, Chang-Ki, Lipton, Stuart A.
Publicado 2022

Redox Regulation of Protein Function via Cysteine S-Nitrosylation and Its Relevance to Neurodegenerative Diseases

por Akhtar, Mohd Waseem, Sunico, Carmen R., Nakamura, Tomohiro, Lipton, Stuart A.
Publicado 2012

Nrf2 and HSF-1 Pathway Activation via Hydroquinone-Based Proelectrophilic Small Molecules Is Regulated by Electrochemical Oxidation Potential

por Satoh, Takumi, Stalder, Romain, McKercher, Scott R., Williamson, Robert E., Roth, Gregory P., Lipton, Stuart A.
Publicado 2015

Genetic Deletion of NR3A Accelerates Glutamatergic Synapse Maturation

por Henson, Maile A., Larsen, Rylan S., Lawson, Shelikha N., Pérez-Otaño, Isabel, Nakanishi, Nobuki, Lipton, Stuart A., Philpot, Benjamin D.
Publicado 2012

Transcriptional profiling of MEF2-regulated genes in human neural progenitor cells derived from embryonic stem cells

por Chan, Shing Fai, Huang, Xiayu, McKercher, Scott R., Zaidi, Rameez, Okamoto, Shu-ichi, Nakanishi, Nobuki, Lipton, Stuart A.
Publicado 2014

Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress

por Nakato, Ryosuke, Ohkubo, Yu, Konishi, Akari, Shibata, Mari, Kaneko, Yuki, Iwawaki, Takao, Nakamura, Tomohiro, Lipton, Stuart A., Uehara, Takashi
Publicado 2015

Molecular Pathway to Protection From Age-Dependent Photoreceptor Degeneration in Mef2 Deficiency

por Nagar, Saumya, Trudler, Dorit, McKercher, Scott R., Piña-Crespo, Juan, Nakanishi, Nobuki, Okamoto, Shu-Ichi, Lipton, Stuart A.
Publicado 2017

Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls

por Ghatak, Swagata, Dolatabadi, Nima, Trudler, Dorit, Zhang, XiaoTong, Wu, Yin, Mohata, Madhav, Ambasudhan, Rajesh, Talantova, Maria, Lipton, Stuart A
Publicado 2019

NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration

por Kwak, Young-Don, Ma, Tao, Diao, Shiyong, Zhang, Xue, Chen, Yaomin, Hsu, Janet, Lipton, Stuart A, Masliah, Eliezer, Xu, Huaxi, Liao, Francesca-Fang
Publicado 2010

Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation

por Meng, Fanjun, Yao, Dongdong, Shi, Yang, Kabakoff, Jonathan, Wu, Wei, Reicher, Joshua, Ma, Yuliang, Moosmann, Bernd, Masliah, Eliezer, Lipton, Stuart A, Gu, Zezong
Publicado 2011

Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer’s disease

por Mann, Aman P., Scodeller, Pablo, Hussain, Sazid, Braun, Gary B., Mölder, Tarmo, Toome, Kadri, Ambasudhan, Rajesh, Teesalu, Tambet, Lipton, Stuart A., Ruoslahti, Erkki
Publicado 2017

Publisher Correction: Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer’s disease

por Mann, Aman P., Scodeller, Pablo, Hussain, Sazid, Braun, Gary B., Mölder, Tarmo, Toome, Kadri, Ambasudhan, Rajesh, Teesalu, Tambet, Lipton, Stuart A., Ruoslahti, Erkki
Publicado 2018

Mechanistic insight into female predominance in Alzheimer’s disease based on aberrant protein S-nitrosylation of C3

por Yang, Hongmei, Oh, Chang-ki, Amal, Haitham, Wishnok, John S., Lewis, Sarah, Schahrer, Emily, Trudler, Dorit, Nakamura, Tomohiro, Tannenbaum, Steven R., Lipton, Stuart A.
Publicado 2022

S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson’s disease

por Sunico, Carmen R, Nakamura, Tomohiro, Rockenstein, Edward, Mante, Michael, Adame, Anthony, Chan, Shing Fai, Newmeyer, Traci Fang, Masliah, Eliezer, Nakanishi, Nobuki, Lipton, Stuart A
Publicado 2013