Cancer evolution: Darwin and beyond

por Vendramin, Roberto, Litchfield, Kevin, Swanton, Charles
Publicado 2021

Tumour mutational burden: primary versus metastatic tissue creates systematic bias

por Schnidrig, Desiree, Turajlic, Samra, Litchfield, Kevin
Publicado 2019

Quantifying the heritability of testicular germ cell tumour using both population-based and genomic approaches

por Litchfield, Kevin, Thomsen, Hauke, Mitchell, Jonathan S., Sundquist, Jan, Houlston, Richard S, Hemminki, Kari, Turnbull, Clare
Publicado 2015

Polygenic susceptibility to testicular cancer: implications for personalised health care

por Litchfield, Kevin, Mitchell, Jonathan S, Shipley, Janet, Huddart, Robert, Rajpert-De Meyts, Ewa, Skakkebæk, Niels E, Houlston, Richard S, Turnbull, Clare
Publicado 2015

Polygenic susceptibility to testicular cancer: implications for personalised health care

por Litchfield, Kevin, Mitchell, Jonathan S, Shipley, Janet, Huddart, Robert, Rajpert-De Meyts, Ewa, Skakkebæk, Niels E, Houlston, Richard S, Turnbull, Clare
Publicado 2016

Classifying cGAS-STING Activity Links Chromosomal Instability with Immunotherapy Response in Metastatic Bladder Cancer

por Sokač, Mateo, Ahrenfeldt, Johanne, Litchfield, Kevin, Watkins, Thomas B.K., Knudsen, Michael, Dyrskjøt, Lars, Jakobsen, Martin R., Birkbak, Nicolai J.
Publicado 2022

Immune Determinants of the Association between Tumor Mutational Burden and Immunotherapy Response across Cancer Types

por Sinha, Neelam, Sinha, Sanju, Valero, Cristina, Schäffer, Alejandro A., Aldape, Kenneth, Litchfield, Kevin, Chan, Timothy A., Morris, Luc G.T., Ruppin, Eytan
Publicado 2022

Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver

por Rodríguez-Martínez, Marta, Boissiére, Thierry, Gonzalez, Melvin Noe, Litchfield, Kevin, Mitter, Richard, Walker, Jane, Kjœr, Svend, Ismail, Mohamed, Downward, Julian, Swanton, Charles, Svejstrup, Jesper Q.
Publicado 2020

Implementation of genome-wide complex trait analysis to quantify the heritability in multiple myeloma

por Mitchell, Jonathan S., Johnson, David C., Litchfield, Kevin, Broderick, Peter, Weinhold, Niels, Davies, Faith E., Gregory, Walter A., Jackson, Graham H., Kaiser, Martin, Morgan, Gareth J., Houlston, Richard S.
Publicado 2015

Whole-exome sequencing reveals the mutational spectrum of testicular germ cell tumours

por Litchfield, Kevin, Summersgill, Brenda, Yost, Shawn, Sultana, Razvan, Labreche, Karim, Dudakia, Darshna, Renwick, Anthony, Seal, Sheila, Al-Saadi, Reem, Broderick, Peter, Turner, Nicholas C., Houlston, Richard S., Huddart, Robert, Shipley, Janet, Turnbull, Clare
Publicado 2015

Quantifying the impact of immunotherapy on RNA dynamics in cancer

por Usaite, Ieva, Biswas, Dhruva, Dijkstra, Krijn, Watkins, Thomas BK, Pich, Oriol, Puttick, Clare, Angelova, Mihaela, Thakkar, Krupa, Hiley, Crispin, Birkbak, Nicolai, Kok, Marleen, Zaccaria, Simone, Wu, Yin, Litchfield, Kevin, Swanton, Charles, Kanu, Nnennaya
Publicado 2023

E3 ubiquitin ligase HECTD2 mediates melanoma progression and immune evasion

por Ottina, Eleonora, Panova, Veera, Doglio, Laura, Kazachenka, Anastasiya, Cornish, Georgina, Kirkpatrick, Joanna, Attig, Jan, Young, George R., Litchfield, Kevin, Lesluyes, Tom, Van Loo, Peter, Swanton, Charles, MacRae, James, Tüting, Thomas, Kassiotis, George
Publicado 2021

Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology

por Ziff, Oliver J., Neeves, Jacob, Mitchell, Jamie, Tyzack, Giulia, Martinez-Ruiz, Carlos, Luisier, Raphaelle, Chakrabarti, Anob M., McGranahan, Nicholas, Litchfield, Kevin, Boulton, Simon J., Al-Chalabi, Ammar, Kelly, Gavin, Humphrey, Jack, Patani, Rickie
Publicado 2023

Identification of four new susceptibility loci for testicular germ cell tumour

por Litchfield, Kevin, Holroyd, Amy, Lloyd, Amy, Broderick, Peter, Nsengimana, Jérémie, Eeles, Rosalind, Easton, Douglas F, Dudakia, Darshna, Bishop, D. Timothy, Reid, Alison, Huddart, Robert A., Grotmol, Tom, Wiklund, Fredrik, Shipley, Janet, Houlston, Richard S., Turnbull, Clare
Publicado 2015

Translational Studies Using the MALT1 Inhibitor (S)-Mepazine to Induce Treg Fragility and Potentiate Immune Checkpoint Therapy in Cancer

por Di Pilato, Mauro, Gao, Yun, Sun, Yi, Fu, Amina, Grass, Carina, Seeholzer, Thomas, Feederle, Regina, Mazo, Irina, Kazer, Samuel W., Litchfield, Kevin, von Andrian, Ulrich H., Mempel, Thorsten R., Jenkins, Russell W., Krappmann, Daniel, Keller, Peter
Publicado 2023

Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility

por Litchfield, Kevin, Levy, Max, Dudakia, Darshna, Proszek, Paula, Shipley, Claire, Basten, Sander, Rapley, Elizabeth, Bishop, D. Timothy, Reid, Alison, Huddart, Robert, Broderick, Peter, Castro, David Gonzalez de, O'Connor, Simon, Giles, Rachel H., Houlston, Richard S., Turnbull, Clare
Publicado 2016

Frequency of pathogenic germline variants in cancer susceptibility genes in 1336 renal cell carcinoma cases

por Yngvadottir, Bryndis, Andreou, Avgi, Bassaganyas, Laia, Larionov, Alexey, Cornish, Alex J, Chubb, Daniel, Saunders, Charlie N, Smith, Philip S, Zhang, Huairen, Cole, Yasemin, Research Consortium, Genomics England, Larkin, James, Browning, Lisa, Turajlic, Samra, Litchfield, Kevin, Houlston, Richard S, Maher, Eamonn R
Publicado 2022

Validation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer

por Loveday, Chey, Litchfield, Kevin, Levy, Max, Holroyd, Amy, Broderick, Peter, Kote-Jarai, Zsofia, Dunning, Alison M, Muir, Kenneth, Peto, Julian, Eeles, Rosalind, Easton, Douglas F, Dudakia, Darshna, Orr, Nick, Pashayan, Nora, Reid, Alison, Huddart, Robert A, Houlston, Richard S, Turnbull, Clare
Publicado 2017

Escape from nonsense-mediated decay associates with anti-tumor immunogenicity

por Litchfield, Kevin, Reading, James L., Lim, Emilia L., Xu, Hang, Liu, Po, Al-Bakir, Maise, Wong, Yien Ning Sophia, Rowan, Andrew, Funt, Samuel A., Merghoub, Taha, Perkins, David, Lauss, Martin, Svane, Inge Marie, Jönsson, Göran, Herrero, Javier, Larkin, James, Quezada, Sergio A., Hellmann, Matthew D., Turajlic, Samra, Swanton, Charles
Publicado 2020

The Immunopeptidome from a Genomic Perspective: Establishing the Noncanonical Landscape of MHC Class I–Associated Peptides

por Bedran, Georges, Gasser, Hans-Christof, Weke, Kenneth, Wang, Tongjie, Bedran, Dominika, Laird, Alexander, Battail, Christophe, Zanzotto, Fabio Massimo, Pesquita, Catia, Axelson, Håkan, Rajan, Ajitha, Harrison, David J., Palkowski, Aleksander, Pawlik, Maciej, Parys, Maciej, O'Neill, J. Robert, Brennan, Paul M., Symeonides, Stefan N., Goodlett, David R., Litchfield, Kevin, Fahraeus, Robin, Hupp, Ted R., Kote, Sachin, Alfaro, Javier A.
Publicado 2023