The biosynthetic pathway to tetromadurin (SF2487/A80577), a polyether tetronate antibiotic

por Little, Rory F., Samborskyy, Markiyan, Leadlay, Peter F.
Publicado 2020

An intramodular thioesterase domain catalyses chain release in the biosynthesis of a cytotoxic virulence factor

por Little, Rory, Trottmann, Felix, Preissler, Miriam, Hertweck, Christian
Publicado 2022

Insect‐Associated Bacteria Assemble the Antifungal Butenolide Gladiofungin by Non‐Canonical Polyketide Chain Termination

por Niehs, Sarah P., Kumpfmüller, Jana, Dose, Benjamin, Little, Rory F., Ishida, Keishi, Flórez, Laura V., Kaltenpoth, Martin, Hertweck, Christian
Publicado 2020

Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active-site residues

por Hall, Kelsi R, Robins, Katherine J, Williams, Elsie M, Rich, Michelle H, Calcott, Mark J, Copp, Janine N, Little, Rory F, Schwörer, Ralf, Evans, Gary B, Patrick, Wayne M, Ackerley, David F
Publicado 2020

Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections

por Copp, Janine N., Pletzer, Daniel, Brown, Alistair S., Van der Heijden, Joris, Miton, Charlotte M., Edgar, Rebecca J., Rich, Michelle H., Little, Rory F., Williams, Elsie M., Hancock, Robert E. W., Tokuriki, Nobuhiko, Ackerley, David F.
Publicado 2020

A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening

por Rich, Michelle H, Sharrock, Abigail V, Mulligan, Timothy S, Matthews, Frazer, Brown, Alistair S, Lee-Harwood, Hannah R, Williams, Elsie M, Copp, Janine N, Little, Rory F, Francis, Jenni JB, Horvat, Claire N, Stevenson, Luke J, Owen, Jeremy G, Saxena, Meera T, Mumm, Jeff S, Ackerley, David F
Publicado 2023