A phase I, single‐center, open‐label study to investigate the absorption, distribution, metabolism and excretion of encorafenib following a single oral dose of 100 mg [ (14)C] enco...

por Wollenberg, Lance, Hahn, Erik, Williams, Jason, Litwiler, Kevin
Publicado 2023

Effect of Food and a Proton-Pump Inhibitor on the Absorption of Encorafenib: An In Vivo–In Vitro–In Silico Approach

por Piscitelli, Joseph, Hens, Bart, Tomaszewska, Irena, Wollenberg, Lance, Litwiler, Kevin, McAllister, Mark, Reddy, Micaela
Publicado 2023

An exploratory, randomized, parallel-group, open-label, relative bioavailability study with an additional two-period crossover food-effect study exploring the pharmacokinetics of t...

por Wollenberg, Lance A, Corson, Donald T, Nugent, Courtney A, Peterson, Farran L, Ptaszynski, Ann M, Arrigo, Alisha, Mannila, Coralee G, Litwiler, Kevin S, Bell, Stacie J
Publicado 2015

A Phase Ib/II Study of WNT974 + Encorafenib + Cetuximab in Patients With BRAF (V600E)-Mutant KRAS Wild-Type Metastatic Colorectal Cancer

por Tabernero, Josep, Van Cutsem, Eric, Garralda, Elena, Tai, David, De Braud, Filippo, Geva, Ravit, van Bussel, Mark T J, Fiorella Dotti, Katia, Elez, Elena, de Miguel, María J, Litwiler, Kevin, Murphy, Danielle, Edwards, Michelle, Morris, Van Karlyle
Publicado 2023