Cytosolic DNA sensing by cGAS: regulation, function, and human diseases

por Yu, Le, Liu, Pengda
Publicado 2021

Experimental Approaches in Delineating mTOR Signaling

por Qian, Jiayi, Su, Siyuan, Liu, Pengda
Publicado 2020

Regulation of EWSR1-FLI1 Function by Post-Transcriptional and Post-Translational Modifications

por Yu, Le, Davis, Ian J., Liu, Pengda
Publicado 2023

Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity

por Liu, Pengda, Guo, Jianping, Gan, Wenjian, Wei, Wenyi
Publicado 2014

Protocol for Monitoring DNA-Triggered cGAS/STING Signaling in Mammalian Cells and Mice

por Wang, Ying, Ma, Zhe, Damania, Blossom, Liu, Pengda
Publicado 2020

Control of mTOR Signaling by Ubiquitin

por Jiang, Yao, Su, Siyuan, Zhang, Yanqiong, Qian, Jiayi, Liu, Pengda
Publicado 2019

Acetylation-dependent regulation of essential iPS-inducing factors: a regulatory crossroad for pluripotency and tumorigenesis

por Dai, Xiangpeng, Liu, Pengda, Lau, Alan W, Liu, Yueyong, Inuzuka, Hiroyuki
Publicado 2014

Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways

por Deng, Yu, Wang, Ying, Li, Lupeng, Miao, Edward A., Liu, Pengda
Publicado 2022

Mcl-1 Ubiquitination and Destruction

por Inuzuka, Hiroyuki, Fukushima, Hidefumi, Shaik, Shavali, Liu, Pengda, Lau, Alan W., Wei, Wenyi
Publicado 2011

DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction

por Wang, Zhiwei, Inuzuka, Hiroyuki, Zhong, Jiateng, Fukushima, Hidefumi, Wan, Lixin, Liu, Pengda, Wei, Wenyi
Publicado 2012

SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway

por Liu, Jia, Wan, Lixin, Liu, Pengda, Inuzuka, Hiroyuki, Liu, Jiankang, Wang, Zhiwei, Wei, Wenyi
Publicado 2014

Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2

por Wang, Zhiwei, Inuzuka, Hiroyuki, Zhong, Jiateng, Liu, Pengda, Sarkar, Fazlul H., Sun, Yi, Wei, Wenyi
Publicado 2012

Lenalidomide downregulates ACE2 protein abundance to alleviate infection by SARS-CoV-2 spike protein conditioned pseudoviruses

por Su, Siyuan, Chen, Jianfeng, Wang, Ying, Wong, Lilly M., Zhu, Zhichuan, Jiang, Guochun, Liu, Pengda
Publicado 2021

Skp2 is a Promising Therapeutic Target in Breast Cancer

por Wang, Zhiwei, Fukushima, Hidefumi, Inuzuka, Hiroyuki, Wan, Lixin, Liu, Pengda, Gao, Daming, Sarkar, Fazlul H., Wei, Wenyi
Publicado 2012

TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877

por Antonia, Ricardo J., Castillo, Johnny, Herring, Laura E., Serafin, D. Stephen, Liu, Pengda, Graves, Lee M., Baldwin, Albert S., Hagan, Robert S.
Publicado 2019

AtomNet-Aided OTUD7B Inhibitor Discovery and Validation

por Chen, Jianfeng, Bolhuis, Derek L., Laggner, Christian, Kong, Deyu, Yu, Le, Wang, Xiaodong, Emanuele, Michael J., Brown, Nicholas G., Liu, Pengda
Publicado 2023

Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy

por Kim, Byeong Mo, Hong, Yunkyung, Lee, Seunghoon, Liu, Pengda, Lim, Ji Hong, Lee, Yong Heon, Lee, Tae Ho, Chang, Kyu Tae, Hong, Yonggeun
Publicado 2015

Streptavidin Promotes DNA Binding and Activation of cGAS to Enhance Innate Immunity

por Zhang, Yanqiong, Ma, Zhe, Wang, Ying, Boyer, Joshua, Ni, Guoxin, Cheng, Liang, Su, Siyuan, Zhang, Zhigang, Zhu, Zhichuan, Qian, Jiayi, Su, Lishan, Zhang, Qi, Damania, Blossom, Liu, Pengda
Publicado 2020

Akt methylation by SETDB1 promotes Akt kinase activity and oncogenic functions

por Guo, Jianping, Dai, Xiangpeng, Laurent, Benoit, Zheng, Nana, Gan, Wenjian, Zhang, Jian, Guo, Ailan, Yuan, Min, Liu, Pengda, Asara, John M., Toker, Alex, Shi, Yang, Pandolfi, Pier Paolo, Wei, Wenyi
Publicado 2019

SPOP and OTUD7A Control EWS–FLI1 Protein Stability to Govern Ewing Sarcoma Growth

por Su, Siyuan, Chen, Jianfeng, Jiang, Yao, Wang, Ying, Vital, Tamara, Zhang, Jiaming, Laggner, Christian, Nguyen, Kong T., Zhu, Zhichuan, Prevatte, Alex W., Barker, Natalie K., Herring, Laura E., Davis, Ian J., Liu, Pengda
Publicado 2021