Targeted proteolytic products of τ and α-synuclein in neurodegeneration

por Xia, Yuxing, Lloyd, Grace M., Giasson, Benoit I.
Publicado 2021

Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy

por Hass, Ethan W., Sorrentino, Zachary A., Lloyd, Grace M., McFarland, Nikolaus R., Prokop, Stefan, Giasson, Benoit I.
Publicado 2021

Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies

por Hass, Ethan W., Sorrentino, Zachary A., Xia, Yuxing, Lloyd, Grace M., Trojanowski, John Q., Prokop, Stefan, Giasson, Benoit I.
Publicado 2021

Precision therapeutic targets for COVID-19

por Krumm, Zachary A., Lloyd, Grace M., Francis, Connor P., Nasif, Lith H., Mitchell, Duane A., Golde, Todd E., Giasson, Benoit I., Xia, Yuxing
Publicado 2021

Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model

por Lloyd, Grace M., Dhillon, Jess-Karan S., Gorion, Kimberly-Marie M., Riffe, Cara, Fromholt, Susan E., Xia, Yuxing, Giasson, Benoit I., Borchelt, David R.
Publicado 2021

Cellular processing of α-synuclein fibrils results in distinct physiological C-terminal truncations with a major cleavage site at residue Glu 114

por Quintin, Stephan, Lloyd, Grace M., Paterno, Giavanna, Xia, Yuxing, Sorrentino, Zachary, Bell, Brach M., Gorion, Kimberly-Marie, Lee, Edward B., Prokop, Stefan, Giasson, Benoit I.
Publicado 2023

Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesis

por Lloyd, Grace M., Long, Brooke, Quintin, Stephan, Sorrentino, Zachary A., Gorion, Kimberly-Marie M., Bell, Brach M., Carrillo, Denise, Sullivan, Patrick, Borchelt, David, Giasson, Benoit I.
Publicado 2023

Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier – phenotypic variability in autosomal dominant Alzheimer’s disease

por Lloyd, Grace M., Trejo-Lopez, Jorge A., Xia, Yuxing, McFarland, Karen N., Lincoln, Sarah J., Ertekin-Taner, Nilüfer, Giasson, Benoit I., Yachnis, Anthony T., Prokop, Stefan
Publicado 2020