Identification of Novel Cdc7 Kinase Inhibitors as Anti-Cancer Agents that Target the Interaction with Dbf4 by the Fragment Complementation and Drug Repositioning Approach

por Cheng, An Ning, Lo, Yu-Kang, Lin, Yi-Sheng, Tang, Tswen-Kei, Hsu, Chun-Hua, Hsu, John T.-A., Lee, Alan Yueh-Luen
Publicado 2018

Lon upregulation contributes to cisplatin resistance by triggering NCLX-mediated mitochondrial Ca(2+) release in cancer cells

por Tangeda, Vidhya, Lo, Yu Kang, Babuharisankar, Ananth Ponneri, Chou, Han-Yu, Kuo, Cheng-Liang, Kao, Yung-Hsi, Lee, Alan Yueh-Luen, Chang, Jang-Yang
Publicado 2022

Cdc6 cooperates with c-Myc to promote genome instability and epithelial to mesenchymal transition (EMT) in zebrafish

por Chen, Ching-Hung, Lin, Dar-Shong, Cheng, Chieh-Wen, Lin, Chun-Ju, Lo, Yu-Kang, Yen, Chueh-Chuan, Lee, Alan Yueh-Luen, Hsiao, Chung-Der
Publicado 2014

Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?

por Kuo, Cheng-Liang, Ponneri Babuharisankar, Ananth, Lin, Ying-Chen, Lien, Hui-Wen, Lo, Yu Kang, Chou, Han-Yu, Tangeda, Vidhya, Cheng, Li-Chun, Cheng, An Ning, Lee, Alan Yueh-Luen
Publicado 2022

Mitochondrial Lon-induced mtDNA leakage contributes to PD-L1–mediated immunoescape via STING-IFN signaling and extracellular vesicles

por Cheng, An Ning, Cheng, Li-Chun, Kuo, Cheng-Liang, Lo, Yu Kang, Chou, Han-Yu, Chen, Chung-Hsing, Wang, Yi-Hao, Chuang, Tsung-Hsien, Cheng, Shih-Jung, Lee, Alan Yueh-Luen
Publicado 2020

Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer

por Cheng, An Ning, Fan, Chi-Chen, Lo, Yu-Kang, Kuo, Cheng-Liang, Wang, Hui-Chun, Lien, I.-Hsin, Lin, Shu-Yu, Chen, Chung-Hsing, Jiang, Shih Sheng, Chang, I.-Shou, Juan, Hsueh-Fen, Lyu, Ping-Chiang, Lee, Alan Yueh-Luen
Publicado 2017

Mitochondrial Lon sequesters and stabilizes p53 in the matrix to restrain apoptosis under oxidative stress via its chaperone activity

por Sung, Ya-Ju, Kao, Ting-Yu, Kuo, Cheng-Liang, Fan, Chi-Chen, Cheng, An Ning, Fang, Wei-Cheng, Chou, Han-Yu, Lo, Yu-Kang, Chen, Chung-Hsing, Jiang, Shih Sheng, Chang, I-Shou, Hsu, Chun-Hua, Lee, Jin-Ching, Lee, Alan Yueh-Luen
Publicado 2018