Phase 1b/2a study of trastuzumab emtansine (T-DM1), paclitaxel, and pertuzumab in HER2-positive metastatic breast cancer

por Krop, Ian E., Modi, Shanu, LoRusso, Patricia M., Pegram, Mark, Guardino, Ellie, Althaus, Betsy, Lu, Dan, Strasak, Alexander, Elias, Anthony
Publicado 2016

Preclinical and first‐in‐human phase I studies of KW‐2450, an oral tyrosine kinase inhibitor with insulin‐like growth factor receptor‐1/insulin receptor selectivity

por Schwartz, Gary K., Dickson, Mark A., LoRusso, Patricia M., Sausville, Edward A., Maekawa, Yoshimi, Watanabe, Yasuo, Kashima, Naomi, Nakashima, Daisuke, Akinaga, Shiro
Publicado 2016

A phase I dose-escalation study of selumetinib in combination with docetaxel or dacarbazine in patients with advanced solid tumors

por LoRusso, Patricia M., Infante, Jeffrey R., Kim, Kevin B., Burris, Howard A., Curt, Gregory, Emeribe, Ugochi, Clemett, Delyth, Tomkinson, Helen K., Cohen, Roger B.
Publicado 2017

A phase I dose-escalation study of Selumetinib in combination with Erlotinib or Temsirolimus in patients with advanced solid tumors

por Infante, Jeffrey R., Cohen, Roger B., Kim, Kevin B., Burris, Howard A., Curt, Gregory, Emeribe, Ugochi, Clemett, Delyth, Tomkinson, Helen K., LoRusso, Patricia M.
Publicado 2017

Erratum to: A phase I dose-escalation study of Selumetinib in combination with Erlotinib or Temsirolimus in patients with advanced solid tumors

por Infante, Jeffrey R., Cohen, Roger B., Kim, Kevin B., Burris, Howard A., Curt, Gregory, Emeribe, Ugochi, Clemett, Delyth, Tomkinson, Helen K., LoRusso, Patricia M.
Publicado 2017

Clinical Activity and Safety of Cediranib and Olaparib Combination in Patients with Metastatic Pancreatic Ductal Adenocarcinoma without BRCA Mutation

por Kim, Joseph W., Cardin, Dana B., Vaishampayan, Ulka N., Kato, Shumei, Grossman, Steven R., Glazer, Peter M., Shyr, Yu, Ivy, S. Percy, LoRusso, Patricia M.
Publicado 2021

Protein Expression of DNA Damage Repair Proteins Dictates Response to Topoisomerase and PARP Inhibitors in Triple-Negative Breast Cancer

por Boerner, Julie L., Nechiporchik, Nicole, Mueller, Kelly L., Polin, Lisa, Heilbrun, Lance, Boerner, Scott A., Zoratti, Gina L., Stark, Karri, LoRusso, Patricia M., Burger, Angelika
Publicado 2015

Phase I dose-escalation study of cabazitaxel administered in combination with gemcitabine in patients with metastatic or unresectable advanced solid malignancies

por Rixe, Olivier, Puzanov, Igor, LoRusso, Patricia M., Cohen, Roger B., Morris, John C., Olowokure, Olugbenga O., Yin, Jian Y., Doroumian, Séverine, Shen, Liji, Olszanski, Anthony J.
Publicado 2015

Dose escalation results from a first-in-human, phase 1 study of glucocorticoid-induced TNF receptor–related protein agonist AMG 228 in patients with advanced solid tumors

por Tran, Ben, Carvajal, Richard D., Marabelle, Aurelien, Patel, Sandip Pravin, LoRusso, Patricia M., Rasmussen, Erik, Juan, Gloria, Upreti, Vijay V., Beers, Courtney, Ngarmchamnanrith, Gataree, Schöffski, Patrick
Publicado 2018

SARS-CoV-2 vaccination and phase 1 cancer clinical trials

por Yap, Timothy A, Siu, Lillian L, Calvo, Emiliano, Lolkema, Martijn P, LoRusso, Patricia M, Soria, Jean-Charles, Plummer, Ruth, de Bono, Johann S, Tabernero, Josep, Banerji, Udai
Publicado 2021

Analysis of variability in high throughput screening data: applications to melanoma cell lines and drug responses

por Ding, Kuan-Fu, Finlay, Darren, Yin, Hongwei, Hendricks, William P.D., Sereduk, Chris, Kiefer, Jeffrey, Sekulic, Aleksandar, LoRusso, Patricia M., Vuori, Kristiina, Trent, Jeffrey M., Schork, Nicholas J.
Publicado 2017

Network Rewiring in Cancer: Applications to Melanoma Cell Lines and the Cancer Genome Atlas Patients

por Ding, Kuan-Fu, Finlay, Darren, Yin, Hongwei, Hendricks, William P. D., Sereduk, Chris, Kiefer, Jeffrey, Sekulic, Aleksandar, LoRusso, Patricia M., Vuori, Kristiina, Trent, Jeffrey M., Schork, Nicholas J.
Publicado 2018

Phase I study of the gamma secretase inhibitor PF-03084014 in combination with docetaxel in patients with advanced triple-negative breast cancer

por Locatelli, Marzia A., Aftimos, Philippe, Dees, E. Claire, LoRusso, Patricia M., Pegram, Mark D., Awada, Ahmad, Huang, Bo, Cesari, Rossano, Jiang, Yuqiu, Shaik, M. Naveed, Kern, Kenneth A., Curigliano, Giuseppe
Publicado 2016

Nonlinear mixed effects dose response modeling in high throughput drug screens: application to melanoma cell line analysis

por Ding, Kuan-Fu, Petricoin, Emanuel F., Finlay, Darren, Yin, Hongwei, Hendricks, William P.D., Sereduk, Chris, Kiefer, Jeffrey, Sekulic, Aleksandar, LoRusso, Patricia M., Vuori, Kristiina, Trent, Jeffrey M., Schork, Nicholas J.
Publicado 2017

A first in man, dose-finding study of the mTORC1/mTORC2 inhibitor OSI-027 in patients with advanced solid malignancies

por Mateo, Joaquin, Olmos, David, Dumez, Herlinde, Poondru, Srinivasu, Samberg, Nancy L, Barr, Sharon, Van Tornout, Jan M, Jie, Fei, Sandhu, Shahneen, Tan, Daniel S, Moreno, Victor, LoRusso, Patricia M, Kaye, Stan B, Schöffski, Patrick
Publicado 2016

Improved methods for RNAseq-based alternative splicing analysis

por Halperin, Rebecca F., Hegde, Apurva, Lang, Jessica D., Raupach, Elizabeth A., Legendre, Christophe, Liang, Winnie S., LoRusso, Patricia M., Sekulic, Aleksandar, Sosman, Jeffrey A., Trent, Jeffrey M., Rangasamy, Sampathkumar, Pirrotte, Patrick, Schork, Nicholas J.
Publicado 2021

Clinical pharmacology of trastuzumab emtansine (T-DM1): an antibody–drug conjugate in development for the treatment of HER2-positive cancer

por Girish, Sandhya, Gupta, Manish, Wang, Bei, Lu, Dan, Krop, Ian E., Vogel, Charles L., Burris III, Howard A., LoRusso, Patricia M., Yi, Joo-Hee, Saad, Ola, Tong, Barbara, Chu, Yu-Waye, Holden, Scott, Joshi, Amita
Publicado 2012

Exploring the safety, effect on the tumor microenvironment, and efficacy of itacitinib in combination with epacadostat or parsaclisib in advanced solid tumors: a phase I study

por Naing, Aung, Powderly, John D, Nemunaitis, John J, Luke, Jason J, Mansfield, Aaron S, Messersmith, Wells A, Sahebjam, Solmaz, LoRusso, Patricia M, Garrido-Laguna, Ignacio, Leopold, Lance, Geschwindt, Ryan, Ding, Kai, Smith, Michael, Berlin, Jordan D
Publicado 2022

Evaluation of pre-analytical factors affecting plasma DNA analysis

por Markus, Havell, Contente-Cuomo, Tania, Farooq, Maria, Liang, Winnie S., Borad, Mitesh J., Sivakumar, Shivan, Gollins, Simon, Tran, Nhan L., Dhruv, Harshil D., Berens, Michael E., Bryce, Alan, Sekulic, Aleksandar, Ribas, Antoni, Trent, Jeffrey M., LoRusso, Patricia M., Murtaza, Muhammed
Publicado 2018

A phase 2 study of vorinostat in locally advanced, recurrent, or metastatic adenoid cystic carcinoma

por Goncalves, Priscila H., Heilbrun, Lance K., Barrett, Michael T., Kummar, Shivaani, Hansen, Aaron R., Siu, Lillian L., Piekarz, Richard L., Sukari, Ammar W., Chao, Joseph, Pilat, Mary Jo, Smith, Daryn W., Casetta, Lindsay, Boerner, Scott A., Chen, Alice, Lenkiewicz, Elizabeth, Malasi, Smriti, LoRusso, Patricia M.
Publicado 2017