Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases

por Hédou, Damien, Godeau, Julien, Loaëc, Nadège, Meijer, Laurent, Fruit, Corinne, Besson, Thierry
Publicado 2016

Synthesis of Bioactive 2-(Arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff Reaction or Cu- Catalyzed Intramolecular C-S Bond Formation

por Hédou, Damien, Dubouilh-Benard, Carole, Loaëc, Nadège, Meijer, Laurent, Fruit, Corinne, Besson, Thierry
Publicado 2016

Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design

por Meine, Rosanna, Becker, Walter, Falke, Hannes, Preu, Lutz, Loaëc, Nadège, Meijer, Laurent, Kunick, Conrad
Publicado 2018

Exploring Kinase Inhibition Properties of 9H-pyrimido[5,4-b]- and [4,5-b]indol-4-amine Derivatives

por Loidreau, Yvonnick, Dubouilh-Benard, Carole, Nourrisson, Marie-Renée, Loaëc, Nadège, Meijer, Laurent, Besson, Thierry, Marchand, Pascal
Publicado 2020

Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype

por Walter, Anne, Chaikuad, Apirat, Helmer, Renate, Loaëc, Nadège, Preu, Lutz, Ott, Ingo, Knapp, Stefan, Meijer, Laurent, Kunick, Conrad
Publicado 2018

[b]-Annulated Halogen-Substituted Indoles as Potential DYRK1A Inhibitors

por Lechner, Christian, Flaßhoff, Maren, Falke, Hannes, Preu, Lutz, Loaëc, Nadége, Meijer, Laurent, Knapp, Stefan, Chaikuad, Apirat, Kunick, Conrad
Publicado 2019

Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp.

por He, Fei, Mai, Linh H., Longeon, Arlette, Copp, Brent R., Loaëc, Nadège, Bescond, Amandine, Meijer, Laurent, Bourguet-Kondracki, Marie-Lise
Publicado 2015

Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part I

por Foucourt, Alicia, Hédou, Damien, Dubouilh-Benard, Carole, Désiré, Laurent, Casagrande, Anne-Sophie, Leblond, Bertrand, Loäec, Nadège, Meijer, Laurent, Besson, Thierry
Publicado 2014

Sneaking Out for Happy Hour: Yeast-Based Approaches to Explore and Modulate Immune Response and Immune Evasion

por Angrand, Gaëlle, Quillévéré, Alicia, Loaëc, Nadège, Daskalogianni, Chrysoula, Granzhan, Anton, Teulade-Fichou, Marie-Paule, Fahraeus, Robin, Prado Martins, Rodrigo, Blondel, Marc
Publicado 2019

Alternative splicing of BCL-x is controlled by RBM25 binding to a G-quadruplex in BCL-x pre-mRNA

por Le Sénéchal, Ronan, Keruzoré, Marc, Quillévéré, Alicia, Loaëc, Nadège, Dinh, Van-Trang, Reznichenko, Oksana, Guixens-Gallardo, Pedro, Corcos, Laurent, Teulade-Fichou, Marie-Paule, Granzhan, Anton, Blondel, Marc
Publicado 2023

10-Iodo-11H-indolo[3,2-c]quinoline-6-carboxylic Acids Are Selective Inhibitors of DYRK1A

por Falke, Hannes, Chaikuad, Apirat, Becker, Anja, Loaëc, Nadège, Lozach, Olivier, Abu Jhaisha, Samira, Becker, Walter, Jones, Peter G., Preu, Lutz, Baumann, Knut, Knapp, Stefan, Meijer, Laurent, Kunick, Conrad
Publicado 2015

Type I arginine methyltransferases are intervention points to unveil the oncogenic Epstein-Barr virus to the immune system

por Angrand, Gaelle, Quillévéré, Alicia, Loaëc, Nadège, Dinh, Van-Trang, Le Sénéchal, Ronan, Chennoufi, Rahima, Duchambon, Patricia, Keruzoré, Marc, Martins, Rodrigo Prado, Teulade-Fichou, Marie-Paule, Fåhraeus, Robin, Blondel, Marc
Publicado 2022

Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A

por Nguyen, Thu Lan, Duchon, Arnaud, Manousopoulou, Antigoni, Loaëc, Nadège, Villiers, Benoît, Pani, Guillaume, Karatas, Meltem, Mechling, Anna E., Harsan, Laura-Adela, Limanton, Emmanuelle, Bazureau, Jean-Pierre, Carreaux, François, Garbis, Spiros D., Meijer, Laurent, Herault, Yann
Publicado 2018

A new mouse model of ARX dup24 recapitulates the patients’ behavioral and fine motor alterations

por Dubos, Aline, Meziane, Hamid, Iacono, Giovanni, Curie, Aurore, Riet, Fabrice, Martin, Christelle, Loaëc, Nadège, Birling, Marie-Christine, Selloum, Mohammed, Normand, Elisabeth, Pavlovic, Guillaume, Sorg, Tania, Stunnenberg, Henk G, Chelly, Jamel, Humeau, Yann, Friocourt, Gaëlle, Hérault, Yann
Publicado 2018

Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases

por Loaëc, Nadège, Attanasio, Eletta, Villiers, Benoît, Durieu, Emilie, Tahtouh, Tania, Cam, Morgane, Davis, Rohan A., Alencar, Aline, Roué, Mélanie, Bourguet-Kondracki, Marie-Lise, Proksch, Peter, Limanton, Emmanuelle, Guiheneuf, Solène, Carreaux, François, Bazureau, Jean-Pierre, Klautau, Michelle, Meijer, Laurent
Publicado 2017

Identification of 8-Hydroxyquinoline Derivatives That Decrease Cystathionine Beta Synthase (CBS) Activity

por Conan, Pierre, Léon, Alice, Gourdel, Mathilde, Rollet, Claire, Chaïr, Loubna, Caroff, Noéline, Le Goux, Nelig, Le Jossic-Corcos, Catherine, Sinane, Maha, Gentile, Lucile, Maillebouis, Louise, Loaëc, Nadège, Martin, Jennifer, Vilaire, Marie, Corcos, Laurent, Mignen, Olivier, Croyal, Mikael, Voisset, Cécile, Bihel, Frédéric, Friocourt, Gaëlle
Publicado 2022