Inactivation of apaziquone by haematuria: implications for the design of phase III clinical trials against non-muscle invasive bladder cancer

por Phillips, Roger M., Loadman, Paul M., Reddy, Guru
Publicado 2019

Progress towards a clinically-successful ATR inhibitor for cancer therapy

por Barnieh, Francis M., Loadman, Paul M., Falconer, Robert A.
Publicado 2021

FGFR1-Induced Epithelial to Mesenchymal Transition through MAPK/PLCγ/COX-2-Mediated Mechanisms

por Tomlinson, Darren C., Baxter, Euan W., Loadman, Paul M., Hull, Mark A., Knowles, Margaret A.
Publicado 2012

Cancer-specific glycosylation of CD13 impacts its detection and activity in preclinical cancer tissues

por Barnieh, Francis M., Galuska, Sebastian P., Loadman, Paul M., Ward, Simon, Falconer, Robert A., El-Khamisy, Sherif F.
Publicado 2023

Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment

por Elkashef, Sara M., Allison, Simon J., Sadiq, Maria, Basheer, Haneen A., Ribeiro Morais, Goreti, Loadman, Paul M., Pors, Klaus, Falconer, Robert A.
Publicado 2016

A randomized controlled trial of eicosapentaenoic acid and/or aspirin for colorectal adenoma prevention during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme...

por Hull, Mark A, Sandell, Anna C, Montgomery, Alan A, Logan, Richard FA, Clifford, Gayle M, Rees, Colin J, Loadman, Paul M, Whitham, Diane
Publicado 2013

Cyclooxygenase activity mediates colorectal cancer cell resistance to the omega-3 polyunsaturated fatty acid eicosapentaenoic acid

por Volpato, Milene, Ingram, Nicola, Perry, Sarah L, Spencer, Jade, Race, Amanda D, Marshall, Catriona, Hutchinson, John M, Nicolaou, Anna, Loadman, Paul M, Coletta, P Louise, Hull, Mark A
Publicado 2020

Luminal Bioavailability of Orally Administered ω-3 PUFAs in the Distal Small Intestine, and Associated Changes to the Ileal Microbiome, in Humans with a Temporary Ileostomy

por Nana, Gael, Mitra, Suparna, Watson, Henry, Young, Caroline, Wood, Henry M, Perry, Sarah L, Race, Amanda D, Quirke, Philip, Toogood, Giles J, Loadman, Paul M, Hull, Mark A
Publicado 2021

Eicosapentaenoic acid and aspirin, alone and in combination, for the prevention of colorectal adenomas (seAFOod Polyp Prevention trial): a multicentre, randomised, double-blind, pl...

por Hull, Mark A, Sprange, Kirsty, Hepburn, Trish, Tan, Wei, Shafayat, Aisha, Rees, Colin J, Clifford, Gayle, Logan, Richard F, Loadman, Paul M, Williams, Elizabeth A, Whitham, Diane, Montgomery, Alan A
Publicado 2018

A Single Short ‘Tone Burst’ Results in Optimal Drug Delivery to Tumours Using Ultrasound-Triggered Therapeutic Microbubbles

por Ingram, Nicola, McVeigh, Laura E., Abou-Saleh, Radwa H., Batchelor, Damien V. B., Loadman, Paul M., McLaughlan, James R., Markham, Alexander F., Evans, Stephen D., Coletta, P. Louise
Publicado 2022

Cytochrome P450 isoforms 1A1, 1B1 AND 2W1 as targets for therapeutic intervention in head and neck cancer

por Presa, Daniela, Khurram, Syed A., Zubir, Amir Z. A., Smarakan, Sneha, Cooper, Patricia A., Morais, Goreti R., Sadiq, Maria, Sutherland, Mark, Loadman, Paul M., McCaul, James, Shnyder, Steven D., Patterson, Laurence H., Pors, Klaus
Publicado 2021

Polymorphisms in Cyclooxygenase, Lipoxygenase, and TP53 Genes Predict Colorectal Polyp Risk Reduction by Aspirin in the seAFOod Polyp Prevention Trial

por Davies, John R., Mell, Tracey, Fuller, Harriett, Harland, Mark, Saleh, Rasha N.M., Race, Amanda D., Rees, Colin J., Brown, Louise C., Loadman, Paul M., Downing, Amy, Minihane, Anne Marie, Williams, Elizabeth A., Hull, Mark A.
Publicado 2023

Pharmacological Inhibition of polysialyltransferase ST8SiaII Modulates Tumour Cell Migration

por Al-Saraireh, Yousef M. J., Sutherland, Mark, Springett, Bradley R., Freiberger, Friedrich, Ribeiro Morais, Goreti, Loadman, Paul M., Errington, Rachel J., Smith, Paul J., Fukuda, Minoru, Gerardy-Schahn, Rita, Patterson, Laurence H., Shnyder, Steven D., Falconer, Robert A.
Publicado 2013

Theranostic nanoparticles enhance the response of glioblastomas to radiation

por Wu, Wei, Klockow, Jessica L., Mohanty, Suchismita, Ku, Kimberly S., Aghighi, Maryam, Melemenidis, Stavros, Chen, Zixin, Li, Kai, Morais, Goreti Ribeiro, Zhao, Ning, Schlegel, Jürgen, Graves, Edward E., Rao, Jianghong, Loadman, Paul M., Falconer, Robert A., Mukherjee, Sudip, Chin, Frederick T., Daldrup-Link, Heike E.
Publicado 2019

Randomised, placebo-controlled, phase 3 trial of the effect of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) on colorectal cancer recurrence and survival after...

por Hull, Mark A, Ow, Pei Loo, Ruddock, Sharon, Brend, Tim, Smith, Alexandra F, Marshall, Helen, Song, Mingyang, Chan, Andrew T, Garrett, Wendy S, Yilmaz, Omer, Drew, David A, Collinson, Fiona, Cockbain, Andrew J, Jones, Robert, Loadman, Paul M, Hall, Peter S, Moriarty, Catherine, Cairns, David A, Toogood, Giles J
Publicado 2023

Implementing subtype‐specific pre‐clinical models of breast cancer to study pre‐treatment aspirin effects

por Miller, Ian S., Khan, Sonja, Shiels, Liam P., Das, Sudipto, O' Farrell, Alice C., Connor, Kate, Lafferty, Adam, Moran, Bruce, Isella, Claudio, Loadman, Paul, Conroy, Emer, Cohrs, Susan, Schibli, Roger, Kerbel, Robert S., Gallagher, William M., Marangoni, Elisabetta, Bennett, Kathleen, O' Connor, Darran P., Dwyer, Róisín M., Byrne, Annette T.
Publicado 2022

Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumor drug accumulation and limiting bioavailability and toxicit...

por Ingram, Nicola, McVeigh, Laura E., Abou-Saleh, Radwa H., Maynard, Juliana, Peyman, Sally A., McLaughlan, James R., Fairclough, Michael, Marston, Gemma, Valleley, Elizabeth M. A., Jimenez-Macias, Jorge L., Charalambous, Antonia, Townley, William, Haddrick, Malcolm, Wierzbicki, Antonia, Wright, Alexander, Volpato, Milène, Simpson, Peter B., Treanor, Darren E., Thomson, Neil H., Loadman, Paul M., Bushby, Richard J., Johnson, Benjamin R.G., Jones, Pamela F., Evans, J. Anthony, Freear, Steven, Markham, Alexander F., Evans, Stephen D., Coletta, P. Louise
Publicado 2020

Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs

por Eschweiler, Simon, Ramírez-Suástegui, Ciro, Li, Yingcong, King, Emma, Chudley, Lindsey, Thomas, Jaya, Wood, Oliver, von Witzleben, Adrian, Jeffrey, Danielle, McCann, Katy, Simon, Hayley, Mondal, Monalisa, Wang, Alice, Dicker, Martina, Lopez-Guadamillas, Elena, Chou, Ting-Fang, Dobbs, Nicola A., Essame, Louisa, Acton, Gary, Kelly, Fiona, Halbert, Gavin, Sacco, Joseph J., Schache, Andrew Graeme, Shaw, Richard, McCaul, James Anthony, Paterson, Claire, Davies, Joseph H., Brennan, Peter A., Singh, Rabindra P., Loadman, Paul M., Wilson, William, Hackshaw, Allan, Seumois, Gregory, Okkenhaug, Klaus, Thomas, Gareth J., Jones, Terry M., Ay, Ferhat, Friberg, Greg, Kronenberg, Mitchell, Vanhaesebroeck, Bart, Vijayanand, Pandurangan, Ottensmeier, Christian H.
Publicado 2022