Targeting chronic and evolving neuroinflammation following traumatic brain injury to improve long-term outcomes: insights from microglial-depletion models

por Henry, Rebecca J., Loane, David J.
Publicado 2020

Acute drivers of neuroinflammation in traumatic brain injury

por Wofford, Kathryn L., Loane, David J., Cullen, D. Kacy
Publicado 2019

Understanding microglial responses in large animal models of traumatic brain injury: an underutilized resource for preclinical and translational research

por Grovola, Michael R., von Reyn, Catherine, Loane, David J., Cullen, D. Kacy
Publicado 2023

Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury

por Byrnes, Kimberly R, Loane, David J, Stoica, Bogdan A, Zhang, Jiangyang, Faden, Alan I
Publicado 2012

Inflammatory response of microglia to prions is controlled by sialylation of PrP(Sc)

por Srivastava, Saurabh, Katorcha, Elizaveta, Makarava, Natallia, Barrett, James P., Loane, David J., Baskakov, Ilia V.
Publicado 2018

Traumatic Brain Injury Induces cGAS Activation and Type I Interferon Signaling in Aged Mice

por Barrett, James P., Knoblach, Susan M., Bhattacharya, Surajit, Gordish-Dressman, Heather, Stoica, Bogdan A., Loane, David J.
Publicado 2021

Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury

por Kumar, Alok, Stoica, Bogdan A., Loane, David J., Yang, Ming, Abulwerdi, Gelareh, Khan, Niaz, Kumar, Asit, Thom, Stephen R., Faden, Alan I.
Publicado 2017

NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for traumatic brain injury

por Barrett, James P., Henry, Rebecca J., Villapol, Sonia, Stoica, Bogdan A., Kumar, Alok, Burns, Mark P., Faden, Alan I., Loane, David J.
Publicado 2017

Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes

por Hegdekar, Nivedita, Sarkar, Chinmoy, Bustos, Sabrina, Ritzel, Rodney M., Hanscom, Marie, Ravishankar, Prarthana, Philkana, Deepika, Wu, Junfang, Loane, David J., Lipinski, Marta M.
Publicado 2023

Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation with exacerbated neurol...

por Hanscom, Marie, Loane, David J., Aubretch, Taryn, Leser, Jenna, Molesworth, Kara, Hedgekar, Nivedita, Ritzel, Rodney M., Abulwerdi, Gelareh, Shea-Donohue, Terez, Faden, Alan I.
Publicado 2021

Region-Specific Homeostatic Identity of Astrocytes Is Essential for Defining Their Response to Pathological Insults

por Makarava, Natallia, Mychko, Olga, Molesworth, Kara, Chang, Jennifer Chen-Yu, Henry, Rebecca J., Tsymbalyuk, Natalya, Gerzanich, Volodymyr, Simard, J. Marc, Loane, David J., Baskakov, Ilia V.
Publicado 2023

The brain-bone marrow axis and its implications for chronic traumatic brain injury

por Ritzel, Rodney M., Li, Yun, Jiao, Yun, Doran, Sarah J., Khan, Niaz, Henry, Rebecca J., Brunner, Kavitha, Loane, David J., Faden, Alan I., Szeto, Gregory L., Wu, Junfang
Publicado 2023

Delayed microglial depletion after spinal cord injury reduces chronic inflammation and neurodegeneration in the brain and improves neurological recovery in male mice

por Li, Yun, Ritzel, Rodney M., Khan, Niaz, Cao, Tuoxin, He, Junyun, Lei, Zhuofan, Matyas, Jessica J., Sabirzhanov, Boris, Liu, Simon, Li, Hui, Stoica, Bogdan A., Loane, David J., Faden, Alan I., Wu, Junfang
Publicado 2020

Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with inflammatory neurodegeneration

por Ritzel, Rodney M., Li, Yun, Jiao, Yun, Lei, Zhuofan, Doran, Sarah J., He, Junyun, Shahror, Rami A., Henry, Rebecca J., Khan, Romeesa, Tan, Chunfeng, Liu, Shaolin, Stoica, Bogdan A., Faden, Alan I., Szeto, Gregory, Loane, David J., Wu, Junfang
Publicado 2023