Structure of the human transcobalamin beta domain in four distinct states

por Bloch, Joël S., Ruetz, Markus, Kräutler, Bernhard, Locher, Kaspar P.
Publicado 2017

A distinct mechanism for the ABC transporter BtuCD-F revealed by the dynamics of complex formation

por Lewinson, Oded, Lee, Allen T., Locher, Kaspar P., Rees, Douglas C.
Publicado 2010

Structure of bacterial oligosaccharyltransferase PglB bound to a reactive LLO and an inhibitory peptide

por Napiórkowska, Maja, Boilevin, Jérémy, Darbre, Tamis, Reymond, Jean-Louis, Locher, Kaspar P.
Publicado 2018

Structural basis of inhibition of lipid-linked oligosaccharide flippase PglK by a conformational nanobody

por Perez, Camilo, Köhler, Martin, Janser, Daniel, Pardon, Els, Steyaert, Jan, Zenobi, Renato, Locher, Kaspar P.
Publicado 2017

Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states

por Manolaridis, Ioannis, Jackson, Scott M., Taylor, Nicholas M. I., Kowal, Julia, Stahlberg, Henning, Locher, Kaspar P.
Publicado 2018

Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism

por Yu, Qin, Ni, Dongchun, Kowal, Julia, Manolaridis, Ioannis, Jackson, Scott M., Stahlberg, Henning, Locher, Kaspar P.
Publicado 2021

Structural basis of the molecular ruler mechanism of a bacterial glycosyltransferase

por Ramírez, Ana S., Boilevin, Jérémy, Mehdipour, Ahmad Reza, Hummer, Gerhard, Darbre, Tamis, Reymond, Jean-Louis, Locher, Kaspar P.
Publicado 2018

Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2

por Rasouli, Ali, Yu, Qin, Dehghani-Ghahnaviyeh, Sepehr, Wen, Po-Chao, Kowal, Julia, Locher, Kaspar P., Tajkhorshid, Emad
Publicado 2022

Structure of human drug transporters OATP1B1 and OATP1B3

por Ciută, Anca-Denise, Nosol, Kamil, Kowal, Julia, Mukherjee, Somnath, Ramírez, Ana S., Stieger, Bruno, Kossiakoff, Anthony A., Locher, Kaspar P.
Publicado 2023

Structural basis of transcobalamin recognition by human CD320 receptor

por Alam, Amer, Woo, Jae-Sung, Schmitz, Jennifer, Prinz, Bernadette, Root, Katharina, Chen, Fan, Bloch, Joël S., Zenobi, Renato, Locher, Kaspar P.
Publicado 2016

Characterization of the single-subunit oligosaccharyltransferase STT3A from Trypanosoma brucei using synthetic peptides and lipid-linked oligosaccharide analogs

por Ramírez, Ana S, Boilevin, Jérémy, Biswas, Rasomoy, Gan, Bee Ha, Janser, Daniel, Aebi, Markus, Darbre, Tamis, Reymond, Jean-Louis, Locher, Kaspar P
Publicado 2017

Chemo-enzymatic synthesis of lipid-linked GlcNAc(2)Man(5) oligosaccharides using recombinant Alg1, Alg2 and Alg11 proteins

por Ramírez, Ana S, Boilevin, Jérémy, Lin, Chia-Wei, Ha Gan, Bee, Janser, Daniel, Aebi, Markus, Darbre, Tamis, Reymond, Jean-Louis, Locher, Kaspar P
Publicado 2017

Substrate specificities and reaction kinetics of the yeast oligosaccharyltransferase isoforms

por Eyring, Jillianne, Lin, Chia-Wei, Ngwa, Elsy Mankah, Boilevin, Jérémy, Pesciullesi, Giorgio, Locher, Kaspar P., Darbre, Tamis, Reymond, Jean-Louis, Aebi, Markus
Publicado 2021

Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver

por Liu, Hongtao, Irobalieva, Rossitza N., Bang-Sørensen, Rose, Nosol, Kamil, Mukherjee, Somnath, Agrawal, Parth, Stieger, Bruno, Kossiakoff, Anthony A., Locher, Kaspar P.
Publicado 2022

Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase

por Ramírez, Ana S., de Capitani, Mario, Pesciullesi, Giorgio, Kowal, Julia, Bloch, Joël S., Irobalieva, Rossitza N., Reymond, Jean-Louis, Aebi, Markus, Locher, Kaspar P.
Publicado 2022

Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP

por Liu, Hongtao, Irobalieva, Rossitza N., Kowal, Julia, Ni, Dongchun, Nosol, Kamil, Bang-Sørensen, Rose, Lancien, Loïck, Stahlberg, Henning, Stieger, Bruno, Locher, Kaspar P.
Publicado 2023

Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1

por Alam, Amer, Küng, Raphael, Kowal, Julia, McLeod, Robert A., Tremp, Nina, Broude, Eugenia V., Roninson, Igor B., Stahlberg, Henning, Locher, Kaspar P.
Publicado 2018

Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase

por Bloch, Joël S., John, Alan, Mao, Runyu, Mukherjee, Somnath, Boilevin, Jérémy, Irobalieva, Rossitza N., Darbre, Tamis, Scott, Nichollas E., Reymond, Jean-Louis, Kossiakoff, Anthony A., Goddard-Borger, Ethan D., Locher, Kaspar P.
Publicado 2023