Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188

por Lockbaum, Gordon J., Reyes, Archie C., Lee, Jeong Min, Tilvawala, Ronak, Nalivaika, Ellen A., Ali, Akbar, Kurt Yilmaz, Nese, Thompson, Paul R., Schiffer, Celia A.
Publicado 2021

Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance

por Spielvogel, Ean, Lee, Sook-Kyung, Zhou, Shuntai, Lockbaum, Gordon J, Henes, Mina, Sondgeroth, Amy, Kosovrasti, Klajdi, Nalivaika, Ellen A, Ali, Akbar, Yilmaz, Nese Kurt, Schiffer, Celia A, Swanstrom, Ronald
Publicado 2023

Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors

por Matthew, Ashley N., Zephyr, Jacqueto, Nageswara Rao, Desaboini, Henes, Mina, Kamran, Wasih, Kosovrasti, Klajdi, Hedger, Adam K., Lockbaum, Gordon J., Timm, Jennifer, Ali, Akbar, Kurt Yilmaz, Nese, Schiffer, Celia A.
Publicado 2020

Unique structural solution from a V(H)3-30 antibody targeting the hemagglutinin stem of influenza A viruses

por Harshbarger, Wayne D., Deming, Derrick, Lockbaum, Gordon J., Attatippaholkun, Nattapol, Kamkaew, Maliwan, Hou, Shurong, Somasundaran, Mohan, Wang, Jennifer P., Finberg, Robert W., Zhu, Quan Karen, Schiffer, Celia A., Marasco, Wayne A.
Publicado 2021

Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance

por Shaqra, Ala M., Zvornicanin, Sarah N., Huang, Qiu Yu J., Lockbaum, Gordon J., Knapp, Mark, Tandeske, Laura, Bakan, David T., Flynn, Julia, Bolon, Daniel N. A., Moquin, Stephanie, Dovala, Dustin, Kurt Yilmaz, Nese, Schiffer, Celia A.
Publicado 2022