RNA Processing and mRNA Surveillance in Monogenic Diabetes

por Locke, Jonathan M., Harries, Lorna W.
Publicado 2008

A rare SNP in pre-miR-34a is associated with increased levels of miR-34a in pancreatic beta cells

por Locke, Jonathan M., Lango Allen, Hana, Harries, Lorna W.
Publicado 2013

A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1

por Locke, Jonathan M., Wei, Fan-Yan, Tomizawa, Kazuhito, Weedon, Michael N., Harries, Lorna W.
Publicado 2015

The splice site variant rs11078928 may be associated with a genotype-dependent alteration in expression of GSDMB transcripts

por Morrison, Faer S, Locke, Jonathan M, Wood, Andrew R, Tuke, Marcus, Pasko, Dorota, Murray, Anna, Frayling, Tim, Harries, Lorna W
Publicado 2013

Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets

por Tugay, Ksenia, Guay, Claudiane, Marques, Ana C., Allagnat, Florent, Locke, Jonathan M., Harries, Lorna W., Rutter, Guy A., Regazzi, Romano
Publicado 2015

Methods for quick, accurate and cost-effective determination of the type 1 diabetes genetic risk score (T1D-GRS)

por Locke, Jonathan M., Latten, Mark J., Datta, Renu Y., Wood, Andrew R., Crockard, Martin A., Lamont, John V., Weedon, Michael N., Oram, Richard A.
Publicado 2020

Genome-Wide Homozygosity Analysis Reveals HADH Mutations as a Common Cause of Diazoxide-Responsive Hyperinsulinemic-Hypoglycemia in Consanguineous Pedigrees

por Flanagan, Sarah E., Patch, Ann-Marie, Locke, Jonathan M., Akcay, Teoman, Simsek, Enver, Alaei, Mohammadreza, Yekta, Zeinab, Desai, Meena, Kapoor, Ritika R., Hussain, Khalid, Ellard, Sian
Publicado 2011

Insights into the genetics of menopausal vasomotor symptoms: genome-wide analyses of routinely-collected primary care health records

por Ruth, Katherine S., Beaumont, Robin N., Locke, Jonathan M., Tyrrell, Jessica, Crandall, Carolyn J., Hawkes, Gareth, Frayling, Timothy M., Prague, Julia K., Patel, Kashyap A., Wood, Andrew R., Weedon, Michael N., Murray, Anna
Publicado 2023

Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis

por Sharp, Seth A., Rich, Stephen S., Wood, Andrew R., Jones, Samuel E., Beaumont, Robin N., Harrison, James W., Schneider, Darius A., Locke, Jonathan M., Tyrrell, Jess, Weedon, Michael N., Hagopian, William A., Oram, Richard A.
Publicado 2019

Association of birthweight and penetrance of diabetes in individuals with HNF4A-MODY: a cohort study

por Locke, Jonathan M., Dusatkova, Petra, Colclough, Kevin, Hughes, Alice E., Dennis, John M., Shields, Beverley, Flanagan, Sarah E., Shepherd, Maggie H., Dempster, Emma L., Hattersley, Andrew T., Weedon, Michael N., Pruhova, Stepanka, Patel, Kashyap A.
Publicado 2021

Loss of MANF Causes Childhood-Onset Syndromic Diabetes Due to Increased Endoplasmic Reticulum Stress

por Montaser, Hossam, Patel, Kashyap A., Balboa, Diego, Ibrahim, Hazem, Lithovius, Väinö, Näätänen, Anna, Chandra, Vikash, Demir, Korcan, Acar, Sezer, Ben-Omran, Tawfeg, Colclough, Kevin, Locke, Jonathan M., Wakeling, Matthew, Lindahl, Maria, Hattersley, Andrew T., Saarimäki-Vire, Jonna, Otonkoski, Timo
Publicado 2021

Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease s...

por Sioofy-Khojine, Amir-Babak, Richardson, Sarah J., Locke, Jonathan M., Oikarinen, Sami, Nurminen, Noora, Laine, Antti-Pekka, Downes, Kate, Lempainen, Johanna, Todd, John A., Veijola, Riitta, Ilonen, Jorma, Knip, Mikael, Morgan, Noel G., Hyöty, Heikki, Peakman, Mark, Eichmann, Martin
Publicado 2022