Juvenile Myelomonocytic Leukemia: Molecular Pathogenesis Informs Current Approaches to Therapy and Hematopoietic Cell Transplantation

por Dvorak, Christopher C., Loh, Mignon L.
Publicado 2014

Juvenile myelomonocytic leukemia in the molecular era: a clinician’s guide to diagnosis, risk stratification, and treatment

por Wintering, Astrid, Dvorak, Christopher C., Stieglitz, Elliot, Loh, Mignon L.
Publicado 2021

JMML tumor cells disrupt normal hematopoietic stem cells by imposing inflammatory stress through overproduction of IL-1β

por Yan, Yuhan, Dong, Lei, Chen, Chao, Bunting, Kevin D., Li, Qianjin, Stieglitz, Elliot, Loh, Mignon L., Qu, Cheng-Kui
Publicado 2022

Exploring the genetic and epigenetic origins of juvenile myelomonocytic leukemia using newborn screening samples

por Behnert, Astrid, Meyer, Julia, Parsa, Jahan-Yar, Hechmer, Aaron, Loh, Mignon L., Olshen, Adam, de Smith, Adam J., Stieglitz, Elliot
Publicado 2021

Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations

por Liu, Wei, Yu, Wen-Mei, Zhang, Jing, Chan, Rebecca J., Loh, Mignon L., Zhang, Zheng, Bunting, Kevin D., Qu, Cheng-Kui
Publicado 2016

Dysregulated transcriptional networks in KMT2A- and MLLT10-rearranged T-ALL

por Kang, Huining, Sharma, Nitesh D., Nickl, Christian K., Devidas, Meenakshi, Loh, Mignon L., Hunger, Stephen P., Dunsmore, Kimberly P., Winter, Stuart S., Matlawska-Wasowska, Ksenia
Publicado 2018

Generation of a human Juvenile myelomonocytic leukemia iPSC line, CHOPi001-A, with a mutation in CBL

por Gagne, Alyssa L., Maguire, Jean Ann, Gandre-Babbe, Shilpa, Chou, Stella T., Tasian, Sarah K., Loh, Mignon L., Weiss, Mitchell J., Gadue, Paul, French, Deborah L.
Publicado 2018

Prognostic impact of pretreatment immunoglobulin clonal composition in pediatric B-lymphoblastic leukemia

por Fries, Carol, Lee, Lik Wee, Devidas, Meenakshi, Dai, Yunfeng, Rabin, Karen R., Gupta, Sumit, Loh, Mignon L., Kirsch, Ilan R, Wood, Brent, Rau, Rachel E.
Publicado 2022

Mutation-Specific Signaling Profiles and Kinase Inhibitor Sensitivities of Juvenile Myelomonocytic Leukemia Revealed by Induced Pluripotent Stem Cells

por Tasian, Sarah K, Casas, Jessica A, Posocco, David, Gandre-Babbe, Shilpa, Gagne, Alyssa L, Liang, Ge, Loh, Mignon L, Weiss, Mitchell J, French, Deborah L, Chou, Stella T
Publicado 2018

NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization

por Narang, Sonali, Evensen, Nikki A., Saliba, Jason, Pierro, Joanna, Loh, Mignon L., Brown, Patrick A., Kolekar, Pandurang, Mulder, Heather, Shao, Ying, Easton, John, Ma, Xiaotu, Tsirigos, Aristotelis, Carroll, William L.
Publicado 2023

Recombinant Erwinia asparaginase (JZP458) in acute lymphoblastic leukemia: results from the phase 2/3 AALL1931 study

por Maese, Luke, Loh, Mignon L., Choi, Mi Rim, Lin, Tong, Aoki, Etsuko, Zanette, Michelle, Agarwal, Shirali, Iannone, Robert, Silverman, Jeffrey A., Silverman, Lewis B., Raetz, Elizabeth A., Rau, Rachel E.
Publicado 2023

CD22(low)/Bcl-2(high) expression identifies poor response to inotuzumab ozogamicin in relapsed/refractory acute lymphoblastic leukemia

por Wintering, Astrid, Ishiyama, Kenichi, Tamaki, Stanley, Tamaki, Courtney, Fandel, Joshua, Ji, Lingyun, Wood, Brent L., Shah, Nirali N., Yuan, Constance M., O’Brien, Maureen M., Loh, Mignon L., Diaz-Flores, Ernesto
Publicado 2022

Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia

por Stieglitz, Elliot, Mazor, Tali, Olshen, Adam B., Geng, Huimin, Gelston, Laura C., Akutagawa, Jon, Lipka, Daniel B., Plass, Christoph, Flotho, Christian, Chehab, Farid F., Braun, Benjamin S., Costello, Joseph F., Loh, Mignon L.
Publicado 2017

Epigenetic silencing of SOCS5 potentiates JAK‐STAT signaling and progression of T‐cell acute lymphoblastic leukemia

por Sharma, Nitesh D., Nickl, Christian K., Kang, Huining, Ornatowski, Wojciech, Brown, Roger, Ness, Scott A., Loh, Mignon L., Mullighan, Charles G., Winter, Stuart S., Hunger, Stephen P., Cannon, Judy L., Matlawska‐Wasowska, Ksenia
Publicado 2019

MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy

por Heinrichs, Stefan, Conover, Lillian F, Bueso-Ramos, Carlos E, Kilpivaara, Outi, Stevenson, Kristen, Neuberg, Donna, Loh, Mignon L, Wu, Wen-Shu, Rodig, Scott J, Garcia-Manero, Guillermo, Kantarjian, Hagop M, Look, A Thomas
Publicado 2013

S107: IDENTIFICATION AND CHARACTERIZATION OF GERMLINE NBN VARIANTS RELATED TO B-ALL PREDISPOSITION

por Escherich, Carolin, Chen, Wenan, Yang, Wenjian, Teachey, David T., Raetz, Elizabeth A., Devidas, Meenakshi, Wu, Gang, Nichols, Kim E., Inaba, Hiroto, Pui, Ching-Hon, Jeha, Sima, Hunger, Stephen P., Loh, Mignon L., Yang, Jun J.
Publicado 2023

SARS‐CoV‐2 infections in patients enrolled on the Children's Oncology Group standard‐risk B‐cell acute lymphoblastic leukemia trial, AALL1731

por Elgarten, Caitlin W., Kairalla, John A., Thompson, Joel C., Miller, Tamara P., Wang, Cindy, Conway, Susan, Loh, Mignon L., Raetz, Elizabeth A., Gupta, Sumit, Rau, Rachel E., Angiolillo, Anne, Rabin, Karen R., Alexander, Sarah
Publicado 2023

Tretinoin Enhances the Effects of Chemotherapy in Juvenile Myelomonocytic Leukemia Using an Ex Vivo Drug Sensitivity Assay

por Stieglitz, Elliot, Gu, Christine J., Richardson, Michelle, Kita, Ryosuke, Santaguida, Marianne T., Ali, Kamran A., Strachan, Debbie C., Dhar, Anukriti, Yam, George, Anderson, Wade, Anderson, Erica, Hübner, Juwita, Tasian, Sarah K., Loh, Mignon L., Lacher, Markus D.
Publicado 2023

The EBF1-PDGFRB T681I mutation is highly resistant to imatinib and dasatinib in vitro and detectable in clinical samples prior to treatment

por Tran, Thai Hoa, Nguyen, Jonathan V., Stecula, Adrian, Akutagawa, Jon, Moorman, Anthony V., Braun, Benjamin S., Sali, Andrej, Mullighan, Charles G., Shah, Neil P., Dai, Yunfeng, Devidas, Meenakshi, Roberts, Kathryn G., Smith, Catherine C., Loh, Mignon L.
Publicado 2021

JAK3 Mutations and Mitochondrial Apoptosis Resistance in T-Cell Acute Lymphoblastic Leukemia

por Bodaar, Kimberly, Yamagata, Natsuko, Barthe, Anais, Landrigan, Jack, Chonghaile, Triona Ni, Burns, Melissa, Stevenson, Kristen E., Devidas, Meenakshi, Loh, Mignon L., Hunger, Stephen P., Wood, Brent, Silverman, Lewis B., Teachey, David T., Meijerink, Jules P., Letai, Anthony, Gutierrez, Alejandro
Publicado 2022