Follow the Mutations: Toward Class-Specific, Small-Molecule Reactivation of p53

por Loh, Stewart N.
Publicado 2020

Engineering protein activity into off-the-shelf DNA devices

por Sekhon, Harsimranjit, Loh, Stewart N.
Publicado 2022

Enhancing response of a protein conformational switch by using two disordered ligand binding domains

por Sekhon, Harsimranjit, Ha, Jeung-Hoi, Loh, Stewart N.
Publicado 2023

Converting a Binding Protein into a Biosensing Conformational Switch Using Protein Fragment Exchange

por Zheng, Huimei, Bi, Jing, Krendel, Mira, Loh, Stewart N.
Publicado 2014

Loss of bound zinc facilitates amyloid fibril formation of leukocyte-cell-derived chemotaxin 2 (LECT2)

por Ha, Jeung-Hoi, Tu, Ho-Chou, Wilkens, Stephan, Loh, Stewart N.
Publicado 2021

p53 and Zinc: A Malleable Relationship

por Ha, Jeung-Hoi, Prela, Orjola, Carpizo, Darren R., Loh, Stewart N.
Publicado 2022

Large enhancement of response times of a protein conformational switch by computational design

por DeGrave, Alex J., Ha, Jeung-Hoi, Loh, Stewart N., Chong, Lillian T.
Publicado 2018

Mimicking Kidney Flow Shear Efficiently Induces Aggregation of LECT2, a Protein Involved in Renal Amyloidosis

por Ha, Jeung-Hoi, Xu, Yikang, Sekhon, Harsimranjit, Wilkens, Stephan, Ren, Dacheng, Loh, Stewart N.
Publicado 2023

Small Molecule-Induced Domain Swapping as a Mechanism for Controlling Protein Function and Assembly

por Karchin, Joshua M., Ha, Jeung-Hoi, Namitz, Kevin E., Cosgrove, Michael S., Loh, Stewart N.
Publicado 2017

Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism

por Yu, Xin, Blanden, Adam R., Narayanan, Sumana, Jayakumar, Lalithapriya, Lubin, David, Augeri, David, David Kimball, S., Loh, Stewart N., Carpizo, Darren R.
Publicado 2014

Mechanistic insights into enhancement or inhibition of phase separation by different polyubiquitin chains

por Dao, Thuy P, Yang, Yiran, Presti, Maria F, Cosgrove, Michael S, Hopkins, Jesse B, Ma, Weikang, Loh, Stewart N, Castañeda, Carlos A
Publicado 2022

A generalizable nanopore sensor for highly specific protein detection at single-molecule precision

por Ahmad, Mohammad, Ha, Jeung-Hoi, Mayse, Lauren A., Presti, Maria F., Wolfe, Aaron J., Moody, Kelsey J., Loh, Stewart N., Movileanu, Liviu
Publicado 2023

Zinc shapes the folding landscape of p53 and establishes a pathway for reactivating structurally diverse cancer mutants

por Blanden, Adam R, Yu, Xin, Blayney, Alan J, Demas, Christopher, Ha, Jeung-Hoi, Liu, Yue, Withers, Tracy, Carpizo, Darren R, Loh, Stewart N
Publicado 2020

Discovery of a novel SHIP1 agonist that promotes degradation of lipid-laden phagocytic cargo by microglia

por Pedicone, Chiara, Fernandes, Sandra, Matera, Alessandro, Meyer, Shea T., Loh, Stewart, Ha, Jeung-Hoi, Bernard, Denzil, Chisholm, John D., Paolicelli, Rosa Chiara, Kerr, William G.
Publicado 2022

Tumor suppressor Tsc1 is a new Hsp90 co‐chaperone that facilitates folding of kinase and non‐kinase clients

por Woodford, Mark R, Sager, Rebecca A, Marris, Elijah, Dunn, Diana M, Blanden, Adam R, Murphy, Ryan L, Rensing, Nicholas, Shapiro, Oleg, Panaretou, Barry, Prodromou, Chrisostomos, Loh, Stewart N, Gutmann, David H, Bourboulia, Dimitra, Bratslavsky, Gennady, Wong, Michael, Mollapour, Mehdi
Publicado 2017

The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding

por Woodford, Mark R., Dunn, Diana M., Blanden, Adam R., Capriotti, Dante, Loiselle, David, Prodromou, Chrisostomos, Panaretou, Barry, Hughes, Philip F., Smith, Aaron, Ackerman, Wendi, Haystead, Timothy A., Loh, Stewart N., Bourboulia, Dimitra, Schmidt, Laura S., Marston Linehan, W., Bratslavsky, Gennady, Mollapour, Mehdi
Publicado 2016

EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction

por Zhao, Jing, Blayney, Alan, Liu, Xiaorong, Gandy, Lauren, Jin, Weihua, Yan, Lufeng, Ha, Jeung-Hoi, Canning, Ashley J., Connelly, Michael, Yang, Chao, Liu, Xinyue, Xiao, Yuanyuan, Cosgrove, Michael S., Solmaz, Sozanne R., Zhang, Yingkai, Ban, David, Chen, Jianhan, Loh, Stewart N., Wang, Chunyu
Publicado 2021