Structures of chloramphenicol acetyltransferase III and Escherichia coli β-ketoacylsynthase III co-crystallized with partially hydrolysed acetyl-oxa(dethia)CoA

por Benjamin, Aaron B., Stunkard, Lee M., Ling, Jianheng, Nice, Jaelen N., Lohman, Jeremy R.
Publicado 2023

Enediyne Polyketide Synthases Stereoselectively Reduce the β-Ketoacyl Intermediates to β-d-Hydroxyacyl Intermediates in Enediyne Core Biosynthesis

por Ge, Hui-Ming, Huang, Tingting, Rudolf, Jeffrey D., Lohman, Jeremy R., Huang, Sheng-Xiong, Guo, Xun, Shen, Ben
Publicado 2014

Enediynes: Exploration of microbial genomics to discover new anticancer drug leads

por Shen, Ben, Hindra, Yan, Xiaohui, Huang, Tingting, Ge, Huiming, Yang, Dong, Teng, Qihui, Rudolf, Jeffrey D., Lohman, Jeremy R.
Publicado 2014

Cycloheximide and Actiphenol Production in Streptomyces sp. YIM56141 Governed by Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase

por Yin, Min, Yan, Yijun, Lohman, Jeremy R., Huang, Sheng-Xiong, Ma, Ming, Zhao, Guang-Rong, Xu, Li-Hua, Xiang, Wensheng, Shen, Ben
Publicado 2014

Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis

por Annaval, Thibault, Rudolf, Jeffrey D., Chang, Chin-Yuan, Lohman, Jeremy R., Kim, Youngchang, Bigelow, Lance, Jedrzejczak, Robert, Babnigg, Gyorgy, Joachimiak, Andrzej, Phillips, George N., Shen, Ben
Publicado 2017

Comparative Characterization of the Lactimidomycin and iso-Migrastatin Biosynthetic Machineries Revealing Unusual Features for Acyltransferase-less Type I Polyketide Synthases and...

por Seo, Jeong-Woo, Ma, Ming, Kwong, Thomas, Ju, Jianhua, Lim, Si-Kyu, Jiang, Hui, Lohman, Jeremy R., Yang, Chunying, Cleveland, John, Zazopoulos, Emmanuel, Farnet, Chris M., Shen, Ben
Publicado 2014

Strain Prioritization for Natural Product Discovery by a High-Throughput Real-Time PCR Method

por Hindra, Huang, Tingting, Yang, Dong, Rudolf, Jeffrey D., Xie, Pengfei, Xie, Guangbo, Teng, Qihui, Lohman, Jeremy R., Zhu, Xiangcheng, Huang, Yong, Zhao, Li-Xing, Jiang, Yi, Duan, Yanwen, Shen, Ben
Publicado 2014

Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne A...

por Chang, Chin-Yuan, Lohman, Jeremy R., Cao, Hongnan, Tan, Kemin, Rudolf, Jeffrey D., Ma, Ming, Xu, Weijun, Bingman, Craig A., Yennamalli, Ragothaman M., Bigelow, Lance, Babnigg, Gyorgy, Yan, Xiaohui, Joachimiak, Andrzej, Phillips, George N., Shen, Ben
Publicado 2016

Biosynthetic Potential-Based Strain Prioritization for Natural Product Discovery: A Showcase for Diterpenoid-Producing Actinomycetes

por Xie, Pengfei, Ma, Ming, Rateb, Mostafa E., Shaaban, Khaled A., Yu, Zhiguo, Huang, Sheng-Xiong, Zhao, Li-Xing, Zhu, Xiangcheng, Yan, Yijun, Peterson, Ryan M., Lohman, Jeremy R., Yang, Dong, Yin, Min, Rudolf, Jeffrey D., Jiang, Yi, Duan, Yanwen, Shen, Ben
Publicado 2014

Strain Prioritization and Genome Mining for Enediyne Natural Products

por Yan, Xiaohui, Ge, Huiming, Huang, Tingting, Hindra, Yang, Dong, Teng, Qihui, Crnovčić, Ivana, Li, Xiuling, Rudolf, Jeffrey D., Lohman, Jeremy R., Gansemans, Yannick, Zhu, Xiangcheng, Huang, Yong, Zhao, Li-Xing, Jiang, Yi, Van Nieuwerburgh, Filip, Rader, Christoph, Duan, Yanwen, Shen, Ben
Publicado 2016

Crystal Structure of SgcJ, An NTF2-Like Superfamily Protein Involved in Biosynthesis of the 9-Membered Enediyne Antitumor Antibiotic C-1027

por Huang, Tingting, Chang, Chin-Yuan, Lohman, Jeremy R., Rudolf, Jeffrey D., Kim, Youngchang, Chang, Changsoo, Yang, Dong, Ma, Ming, Yan, Xiaohui, Crnovcic, Ivana, Bigelow, Lance, Clancy, Shonda, Bingman, Craig A., Yennamalli, Ragothaman M., Babnigg, Gyorgy, Joachimiak, Andrzej, Phillips, George N., Shen, Ben
Publicado 2016