The Impact of Population Demography and Selection on the Genetic Architecture of Complex Traits

por Lohmueller, Kirk E.
Publicado 2014

Inferring the mode and strength of ongoing selection

por Barroso, Gustavo V., Lohmueller, Kirk E.
Publicado 2023

Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genome

por Garcia, Jesse A., Lohmueller, Kirk E.
Publicado 2021

A Model-Based Approach for Identifying Signatures of Ancient Balancing Selection in Genetic Data

por DeGiorgio, Michael, Lohmueller, Kirk E., Nielsen, Rasmus
Publicado 2014

The impact of identity by descent on fitness and disease in dogs

por Mooney, Jazlyn A., Yohannes, Abigail, Lohmueller, Kirk E.
Publicado 2021

Natural Selection Reduced Diversity on Human Y Chromosomes

por Wilson Sayres, Melissa A., Lohmueller, Kirk E., Nielsen, Rasmus
Publicado 2014

Determining the Effect of Natural Selection on Linked Neutral Divergence across Species

por Phung, Tanya N., Huber, Christian D., Lohmueller, Kirk E.
Publicado 2016

Inference of the Distribution of Selection Coefficients for New Nonsynonymous Mutations Using Large Samples

por Kim, Bernard Y., Huber, Christian D., Lohmueller, Kirk E.
Publicado 2017

Comparison of Single Genome and Allele Frequency Data Reveals Discordant Demographic Histories

por Beichman, Annabel C., Phung, Tanya N., Lohmueller, Kirk E.
Publicado 2017

Deleterious variation shapes the genomic landscape of introgression

por Kim, Bernard Y., Huber, Christian D., Lohmueller, Kirk E.
Publicado 2018

Population genetic models of GERP scores suggest pervasive turnover of constrained sites across mammalian evolution

por Huber, Christian D., Kim, Bernard Y., Lohmueller, Kirk E.
Publicado 2020

Strongly deleterious mutations are a primary determinant of extinction risk due to inbreeding depression

por Kyriazis, Christopher C., Wayne, Robert K., Lohmueller, Kirk E.
Publicado 2020

Haplotype-based inference of the distribution of fitness effects

por Ortega-Del Vecchyo, Diego, Lohmueller, Kirk E, Novembre, John
Publicado 2022

The Impact of Recessive Deleterious Variation on Signals of Adaptive Introgression in Human Populations

por Zhang, Xinjun, Kim, Bernard, Lohmueller, Kirk E., Huerta-Sánchez, Emilia
Publicado 2020

Gene expression drives the evolution of dominance

por Huber, Christian D., Durvasula, Arun, Hancock, Angela M., Lohmueller, Kirk E.
Publicado 2018

Greater strength of selection and higher proportion of beneficial amino acid changing mutations in humans compared with mice and Drosophila melanogaster

por Zhen, Ying, Huber, Christian D., Davies, Robert W., Lohmueller, Kirk E.
Publicado 2021

Quantifying the fraction of new mutations that are recessive lethal

por Wade, Emma E, Kyriazis, Christopher C, Cavassim, Maria Izabel A, Lohmueller, Kirk E
Publicado 2023

MaLAdapt Reveals Novel Targets of Adaptive Introgression From Neanderthals and Denisovans in Worldwide Human Populations

por Zhang, Xinjun, Kim, Bernard, Singh, Armaan, Sankararaman, Sriram, Durvasula, Arun, Lohmueller, Kirk E
Publicado 2023

On the prospect of achieving accurate joint estimation of selection with population history

por Johri, Parul, Eyre-Walker, Adam, Gutenkunst, Ryan N, Lohmueller, Kirk E, Jensen, Jeffrey D
Publicado 2022

Long-term Small Population Size, Deleterious Variation, and Altitude Adaptation in the Ethiopian Wolf, a Severely Endangered Canid

por Mooney, Jazlyn A, Marsden, Clare D, Yohannes, Abigail, Wayne, Robert K, Lohmueller, Kirk E
Publicado 2022