Leveraging homologous recombination repair deficiency in sarcoma

por Slade, Dea, Loizou, Joanna I
Publicado 2023

Programmed DNA breaks in lymphoid cells: repair mechanisms and consequences in human disease

por Prochazkova, Jana, Loizou, Joanna I.
Publicado 2015

Interplay between Cellular Metabolism and the DNA Damage Response in Cancer

por Moretton, Amandine, Loizou, Joanna I.
Publicado 2020

Exploring the genetic space of the DNA damage response for cancer therapy through CRISPR‐based screens

por Wilson, Jordan, Loizou, Joanna I.
Publicado 2022

Tissue Specific DNA Repair Outcomes Shape the Landscape of Genome Editing

por Meyenberg, Mathilde, Ferreira da Silva, Joana, Loizou, Joanna I.
Publicado 2021

ATMIN is required for the ATM-mediated signaling and recruitment of 53BP1 to DNA damage sites upon replication stress

por Schmidt, Luisa, Wiedner, Marc, Velimezi, Georgia, Prochazkova, Jana, Owusu, Michel, Bauer, Sabine, Loizou, Joanna I.
Publicado 2014

Validating the concept of mutational signatures with isogenic cell models

por Zou, Xueqing, Owusu, Michel, Harris, Rebecca, Jackson, Stephen P., Loizou, Joanna I., Nik-Zainal, Serena
Publicado 2018

ATMIN Is Required for Maintenance of Genomic Stability and Suppression of B Cell Lymphoma

por Loizou, Joanna I., Sancho, Rocio, Kanu, Nnennaya, Bolland, Daniel J., Yang, Fengtang, Rada, Cristina, Corcoran, Anne E., Behrens, Axel
Publicado 2011

BioProfiling.jl: profiling biological perturbations with high-content imaging in single cells and heterogeneous populations

por Vulliard, Loan, Hancock, Joel, Kamnev, Anton, Fell, Christopher W, Ferreira da Silva, Joana, Loizou, Joanna I, Nagy, Vanja, Dupré, Loïc, Menche, Jörg
Publicado 2021

Clickable Cisplatin Derivatives as Versatile Tools to Probe the DNA Damage Response to Chemotherapy

por Moretton, Amandine, Slyskova, Jana, Simaan, Marwan E., Arasa-Verge, Emili A., Meyenberg, Mathilde, Cerrón-Infantes, D. Alonso, Unterlass, Miriam M., Loizou, Joanna I.
Publicado 2022

Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells

por Ferreira da Silva, Joana, Salic, Sejla, Wiedner, Marc, Datlinger, Paul, Essletzbichler, Patrick, Hanzl, Alexander, Superti-Furga, Giulio, Bock, Christoph, Winter, Georg, Loizou, Joanna I.
Publicado 2019

High-throughput drug screening identifies the ATR-CHK1 pathway as a therapeutic vulnerability of CALR mutated hematopoietic cells

por Jia, Ruochen, Kutzner, Leon, Koren, Anna, Runggatscher, Kathrin, Májek, Peter, Müller, André C., Schuster, Michael, Bock, Christoph, Loizou, Joanna I., Kubicek, Stefan, Kralovics, Robert
Publicado 2021

DNA Repair Cofactors ATMIN and NBS1 Are Required to Suppress T Cell Activation

por Prochazkova, Jana, Sakaguchi, Shinya, Owusu, Michel, Mazouzi, Abdelghani, Wiedner, Marc, Velimezi, Georgia, Moder, Martin, Turchinovich, Gleb, Hladik, Anastasiya, Gurnhofer, Elisabeth, Hayday, Adrian, Behrens, Axel, Knapp, Sylvia, Kenner, Lukas, Ellmeier, Wilfried, Loizou, Joanna I.
Publicado 2015

Detection of oxaliplatin- and cisplatin-DNA lesions requires different global genome repair mechanisms that affect their clinical efficacy

por Slyskova, Jana, Muniesa-Vargas, Alba, da Silva, Israel Tojal, Drummond, Rodrigo, Park, Jiyeong, Häckes, David, Poetsch, Isabella, Ribeiro-Silva, Cristina, Moretton, Amandine, Heffeter, Petra, Schärer, Orlando D, Vermeulen, Wim, Lans, Hannes, Loizou, Joanna I
Publicado 2023

Mutational landscape of intestinal crypt cells after long-term in vivo exposure to high fat diet

por Meyenberg, Mathilde, Hakobyan, Anna, Papac-Milicevic, Nikolina, Göderle, Laura, Langner, Franziska L., Markovic, Mateo, Lee, Ji-Hyun, Koo, Bon-Kyoung, Busslinger, Georg A., da Silva, Israel Tojal, Binder, Christoph J., Menche, Jörg, Loizou, Joanna I.
Publicado 2023

Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia

por Moder, Martin, Velimezi, Georgia, Owusu, Michel, Mazouzi, Abdelghani, Wiedner, Marc, Ferreira da Silva, Joana, Robinson-Garcia, Lydia, Schischlik, Fiorella, Slavkovsky, Rastislav, Kralovics, Robert, Schuster, Michael, Bock, Christoph, Ideker, Trey, Jackson, Stephen P., Menche, Jörg, Loizou, Joanna I.
Publicado 2017

FANCD2-Associated Nuclease 1 Partially Compensates for the Lack of Exonuclease 1 in Mismatch Repair

por Kratz, Katja, Artola-Borán, Mariela, Kobayashi-Era, Saho, Koh, Gene, Oliveira, Goncalo, Kobayashi, Shunsuke, Oliveira, Andreia, Zou, Xueqing, Richter, Julia, Tsuda, Masataka, Sasanuma, Hiroyuki, Takeda, Shunichi, Loizou, Joanna I., Sartori, Alessandro A., Nik-Zainal, Serena, Jiricny, Josef
Publicado 2021

Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48

por Velimezi, Georgia, Robinson-Garcia, Lydia, Muñoz-Martínez, Francisco, Wiegant, Wouter W., Ferreira da Silva, Joana, Owusu, Michel, Moder, Martin, Wiedner, Marc, Rosenthal, Sara Brin, Fisch, Kathleen M., Moffat, Jason, Menche, Jörg, van Attikum, Haico, Jackson, Stephen P., Loizou, Joanna I.
Publicado 2018

A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability

por Moretton, Amandine, Kourtis, Savvas, Gañez Zapater, Antoni, Calabrò, Chiara, Espinar Calvo, Maria Lorena, Fontaine, Frédéric, Darai, Evangelia, Abad Cortel, Etna, Block, Samuel, Pascual‐Reguant, Laura, Pardo‐Lorente, Natalia, Ghose, Ritobrata, Vander Heiden, Matthew G, Janic, Ana, Müller, André C, Loizou, Joanna I, Sdelci, Sara
Publicado 2023

MEK inhibitors block growth of lung tumours with mutations in ataxia–telangiectasia mutated

por Smida, Michal, Fece de la Cruz, Ferran, Kerzendorfer, Claudia, Uras, Iris Z., Mair, Barbara, Mazouzi, Abdelghani, Suchankova, Tereza, Konopka, Tomasz, Katz, Amanda M., Paz, Keren, Nagy-Bojarszky, Katalin, Muellner, Markus K., Bago-Horvath, Zsuzsanna, Haura, Eric B., Loizou, Joanna I., Nijman, Sebastian M. B.
Publicado 2016