DNA-Compatible Conditions for the Formation of N-Methyl Peptide Bonds

por Zhang, Panpan, Koch, Grant, Zhang, Yankun, Yang, Kevin, Lokey, R. Scott
Publicado 2023

Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity

por Klein, Victoria G., Bond, Adam G., Craigon, Conner, Lokey, R. Scott, Ciulli, Alessio
Publicado 2021

Connecting the conformational behavior of cyclic octadepsipeptides with their ionophoric property and membrane permeability

por Stadelmann, Thomas, Subramanian, Govindan, Menon, Sanjay, Townsend, Chad E., Lokey, R. Scott, Ebert, Marc-Olivier, Riniker, Sereina
Publicado 2020

A Cell-Based Screen Reveals that the Albendazole Metabolite, Albendazole Sulfone, Targets Wolbachia

por Serbus, Laura R., Landmann, Frederic, Bray, Walter M., White, Pamela M., Ruybal, Jordan, Lokey, R. Scott, Debec, Alain, Sullivan, William
Publicado 2012

Reevaluation of a Bicyclic Pyrazoline as a Selective 15-Lipoxygenase V-Type Activator Possessing Fatty Acid Specificity

por van Hoorebeke, Christopher, Yang, Kevin, Mussetter, Samuel J., Koch, Grant, Rutz, Natalie, Lokey, R. Scott, Crews, Phillip, Holman, Theodore R.
Publicado 2022

An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications

por Shi, Yihui, Bray, Walter, Smith, Alexander J., Zhou, Wei, Calaoagan, Joy, Lagisetti, Chandraiah, Sambucetti, Lidia, Crews, Phillip, Lokey, R. Scott, Webb, Thomas R.
Publicado 2020

Understanding and Improving the Membrane Permeability of VH032-Based PROTACs

por Klein, Victoria G., Townsend, Chad E., Testa, Andrea, Zengerle, Michael, Maniaci, Chiara, Hughes, Scott J., Chan, Kwok-Ho, Ciulli, Alessio, Lokey, R. Scott
Publicado 2020

Developing Cyclic Peptomers as Broad-Spectrum Type III Secretion System Inhibitors in Gram-Negative Bacteria

por Lam, Hanh N., Lau, Tannia, Lentz, Adam, Sherry, Jessica, Cabrera-Cortez, Alejandro, Hug, Karen, Lalljie, Annalyse, Engel, Joanne, Lokey, R. Scott, Auerbuch, Victoria
Publicado 2021

Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action

por Kapitzky, Laura, Beltrao, Pedro, Berens, Theresa J, Gassner, Nadine, Zhou, Chunshui, Wüster, Arthur, Wu, Julie, Babu, M Madan, Elledge, Stephen J, Toczyski, David, Lokey, R Scott, Krogan, Nevan J
Publicado 2010

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

por White, Tina R., Renzelman, Chad M., Rand, Arthur C., Rezai, Taha, McEwen, Cayla M., Gelev, Vladimir M., Turner, Rushia A., Linington, Roger G., Leung, Siegfried S.F., Kalgutkar, Amit S., Bauman, Jonathan N., Zhang, Yizhong, Liras, Spiros, Price, David A., Mathiowetz, Alan M., Jacobson, Matthew P., Lokey, R. Scott
Publicado 2011

High-throughput functional annotation of natural products by integrated activity profiling

por Hight, Suzie K., Clark, Trevor N., Kurita, Kenji L., McMillan, Elizabeth A., Bray, Walter, Shaikh, Anam F., Khadilkar, Aswad, Haeckl, F. P. Jake, Carnevale-Neto, Fausto, La, Scott, Lohith, Akshar, Vaden, Rachel M., Lee, Jeon, Wei, Shuguang, Lokey, R. Scott, White, Michael A., Linington, Roger G., MacMillan, John B.
Publicado 2022