Polymers and inflammation: disease mechanisms of the serpinopathies

por Gooptu, Bibek, Lomas, David A.
Publicado 2008

Stem cell-based therapy for α(1)-antitrypsin deficiency

por Rashid, S Tamir, Lomas, David A
Publicado 2012

Alpha-1-Antitrypsin Deficiency, the Serpinopathies and Conformational Disease

por Parmar, Jas S, Lomas, David A
Publicado 2000

Why has it been so difficult to prove the efficacy of alpha-1-antitrypsin replacement therapy? Insights from the study of disease pathogenesis

por Dickens, Jennifer A, Lomas, David A
Publicado 2011

The genetics of chronic obstructive pulmonary disease

por Lomas, David A, Silverman, Edwin K
Publicado 2001

Alzheimer's disease: insights from Drosophila melanogaster models

por Moloney, Aileen, Sattelle, David B., Lomas, David A., Crowther, Damian C.
Publicado 2010

The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer’s disease

por Chen, Ko-Fan, Possidente, Bernard, Lomas, David A., Crowther, Damian C.
Publicado 2014

Calcium signalling in mammalian cell lines expressing wild type and mutant human α1-Antitrypsin

por Malintan, Nancy T., Buckingham, Steven D., Lomas, David A., Sattelle, David B.
Publicado 2019

Altered native stability is the dominant basis for susceptibility of α(1)-antitrypsin mutants to polymerization

por Irving, James A., Haq, Imran, Dickens, Jennifer A., Faull, Sarah V., Lomas, David A.
Publicado 2014

High-resolution ex vivo NMR spectroscopy of human Z α(1)-antitrypsin

por Jagger, Alistair M., Waudby, Christopher A., Irving, James A., Christodoulou, John, Lomas, David A.
Publicado 2020

Blood fibrinogen as a biomarker of chronic obstructive pulmonary disease

por Duvoix, Annelyse, Dickens, Jenny, Haq, Imran, Mannino, David, Miller, Bruce, Tal-Singer, Ruth, Lomas, David A
Publicado 2013

Lessons and risks of medical device deployment in a global pandemic

por Shipley, Rebecca J, Brealey, David, Haniffa, Rashan, Elwell, Clare, Baker, Tim, Lomas, David A, Singer, Mervyn
Publicado 2021

Non-invasive testing for liver pathology in alpha-1 antitrypsin deficiency

por Abbas, Syed Hamza, Pickett, Elisha, Lomas, David A, Thorburn, Douglas, Gooptu, Bibek, Hurst, John R, Marshall, Aileen
Publicado 2020

The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB

por Miranda, Elena, MacLeod, Ian, Davies, Mark J., Pérez, Juan, Römisch, Karin, Crowther, Damian C., Lomas, David A.
Publicado 2008

COPD association and repeatability of blood biomarkers in the ECLIPSE cohort

por Dickens, Jennifer A, Miller, Bruce E, Edwards, Lisa D, Silverman, Edwin K, Lomas, David A, Tal-Singer, Ruth
Publicado 2011

Characterisation of a type II functionally-deficient variant of alpha-1-antitrypsin discovered in the general population

por Laffranchi, Mattia, Elliston, Emma L. K., Gangemi, Fabrizio, Berardelli, Romina, Lomas, David A., Irving, James A., Fra, Annamaria
Publicado 2019

Therapeutic target-site variability in α(1)-antitrypsin characterized at high resolution

por Patschull, Anathe O. M., Segu, Lakshmi, Nyon, Mun Peak, Lomas, David A., Nobeli, Irene, Barrett, Tracey E., Gooptu, Bibek
Publicado 2011

Once-Daily Triple Therapy in Patients with COPD: Patient-Reported Symptoms and Quality of Life

por Tabberer, Maggie, Lomas, David A., Birk, Ruby, Brealey, Noushin, Zhu, Chang-Qing, Pascoe, Steve, Locantore, Nicholas, Lipson, David A.
Publicado 2018

Scaling Concepts in Serpin Polymer Physics

por Raccosta, Samuele, Librizzi, Fabio, Jagger, Alistair M., Noto, Rosina, Martorana, Vincenzo, Lomas, David A., Irving, James A., Manno, Mauro
Publicado 2021

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway

por Haq, Imran, Irving, James A., Faull, Sarah V., Dickens, Jennifer A., Ordóñez, Adriana, Belorgey, Didier, Gooptu, Bibek, Lomas, David A.
Publicado 2013