Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing

por Amabile, Angelo, Migliara, Alessandro, Capasso, Paola, Biffi, Mauro, Cittaro, Davide, Naldini, Luigi, Lombardo, Angelo
Publicado 2016

IL-10-Engineered Human CD4(+) Tr1 Cells Eliminate Myeloid Leukemia in an HLA Class I-Dependent Mechanism

por Locafaro, Grazia, Andolfi, Grazia, Russo, Fabio, Cesana, Luca, Spinelli, Antonello, Camisa, Barbara, Ciceri, Fabio, Lombardo, Angelo, Bondanza, Attilio, Roncarolo, Maria Grazia, Gregori, Silvia
Publicado 2017

Engineering of immune checkpoints B7-H3 and CD155 enhances immune compatibility of MHC-I(−/−) iPSCs for β cell replacement

por Chimienti, Raniero, Baccega, Tania, Torchio, Silvia, Manenti, Fabio, Pellegrini, Silvia, Cospito, Alessandro, Amabile, Angelo, Lombardo, Marta Tiffany, Monti, Paolo, Sordi, Valeria, Lombardo, Angelo, Malnati, Mauro, Piemonti, Lorenzo
Publicado 2022

Genome editing for scalable production of alloantigen‐free lentiviral vectors for in vivo gene therapy

por Milani, Michela, Annoni, Andrea, Bartolaccini, Sara, Biffi, Mauro, Russo, Fabio, Di Tomaso, Tiziano, Raimondi, Andrea, Lengler, Johannes, Holmes, Michael C, Scheiflinger, Friedrich, Lombardo, Angelo, Cantore, Alessio, Naldini, Luigi
Publicado 2017

Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency

por Friedli, Marc, Turelli, Priscilla, Kapopoulou, Adamandia, Rauwel, Benjamin, Castro-Díaz, Nathaly, Rowe, Helen M., Ecco, Gabriela, Unzu, Carmen, Planet, Evarist, Lombardo, Angelo, Mangeat, Bastien, Wildhaber, Barbara E., Naldini, Luigi, Trono, Didier
Publicado 2014

Galectin-3 in Prostate Cancer Stem-Like Cells Is Immunosuppressive and Drives Early Metastasis

por Caputo, Sara, Grioni, Matteo, Brambillasca, Chiara S., Monno, Antonella, Brevi, Arianna, Freschi, Massimo, Piras, Ignazio S., Elia, Angela R., Pieri, Valentina, Baccega, Tania, Lombardo, Angelo, Galli, Rossella, Briganti, Alberto, Doglioni, Claudio, Jachetti, Elena, Bellone, Matteo
Publicado 2020

Laboratory-Scale Lentiviral Vector Production and Purification for Enhanced Ex Vivo and In Vivo Genetic Engineering

por Soldi, Monica, Sergi Sergi, Lucia, Unali, Giulia, Kerzel, Thomas, Cuccovillo, Ivan, Capasso, Paola, Annoni, Andrea, Biffi, Mauro, Rancoita, Paola Maria Vittoria, Cantore, Alessio, Lombardo, Angelo, Naldini, Luigi, Squadrito, Mario Leonardo, Kajaste-Rudnitski, Anna
Publicado 2020

Deletion of a pseudogene within a fragile site triggers the oncogenic expression of the mitotic CCSER1 gene

por Santoliquido, Benedetta M, Frenquelli, Michela, Contadini, Claudia, Bestetti, Stefano, Gaviraghi, Marco, Barbieri, Elisa, De Antoni, Anna, Albarello, Luca, Amabile, Angelo, Gardini, Alessandro, Lombardo, Angelo, Doglioni, Claudio, Provero, Paolo, Soddu, Silvia, Cittaro, Davide, Tonon, Giovanni
Publicado 2021

Therapeutic gene editing in CD34(+) hematopoietic progenitors from Fanconi anemia patients

por Diez, Begoña, Genovese, Pietro, Roman‐Rodriguez, Francisco J, Alvarez, Lara, Schiroli, Giulia, Ugalde, Laura, Rodriguez‐Perales, Sandra, Sevilla, Julian, Diaz de Heredia, Cristina, Holmes, Michael C, Lombardo, Angelo, Naldini, Luigi, Bueren, Juan Antonio, Rio, Paula
Publicado 2017

Targeted Genome Editing in Human Repopulating Hematopoietic Stem Cells

por Genovese, Pietro, Schiroli, Giulia, Escobar, Giulia, Tomaso, Tiziano Di, Firrito, Claudia, Calabria, Andrea, Moi, Davide, Mazzieri, Roberta, Bonini, Chiara, Holmes, Michael C., Gregory, Philip D., van der Burg, Mirjam, Gentner, Bernhard, Montini, Eugenio, Lombardo, Angelo, Naldini, Luigi
Publicado 2014

Patient-Specific iPSC-Derived Endothelial Cells Provide Long-Term Phenotypic Correction of Hemophilia A

por Olgasi, Cristina, Talmon, Maria, Merlin, Simone, Cucci, Alessia, Richaud-Patin, Yvonne, Ranaldo, Gabriella, Colangelo, Donato, Di Scipio, Federica, Berta, Giovanni N., Borsotti, Chiara, Valeri, Federica, Faraldi, Francesco, Prat, Maria, Messina, Maria, Schinco, Piercarla, Lombardo, Angelo, Raya, Angel, Follenzi, Antonia
Publicado 2018

Targeted Gene Correction in Osteopetrotic-Induced Pluripotent Stem Cells for the Generation of Functional Osteoclasts

por Neri, Tui, Muggeo, Sharon, Paulis, Marianna, Caldana, Maria Elena, Crisafulli, Laura, Strina, Dario, Focarelli, Maria Luisa, Faggioli, Francesca, Recordati, Camilla, Scaramuzza, Samantha, Scanziani, Eugenio, Mantero, Stefano, Buracchi, Chiara, Sobacchi, Cristina, Lombardo, Angelo, Naldini, Luigi, Vezzoni, Paolo, Villa, Anna, Ficara, Francesca
Publicado 2015

Reversible immortalisation enables genetic correction of human muscle progenitors and engineering of next‐generation human artificial chromosomes for Duchenne muscular dystrophy

por Benedetti, Sara, Uno, Narumi, Hoshiya, Hidetoshi, Ragazzi, Martina, Ferrari, Giulia, Kazuki, Yasuhiro, Moyle, Louise Anne, Tonlorenzi, Rossana, Lombardo, Angelo, Chaouch, Soraya, Mouly, Vincent, Moore, Marc, Popplewell, Linda, Kazuki, Kanako, Katoh, Motonobu, Naldini, Luigi, Dickson, George, Messina, Graziella, Oshimura, Mitsuo, Cossu, Giulio, Tedesco, Francesco Saverio
Publicado 2017

Gene Modification and Three‐Dimensional Scaffolds as Novel Tools to Allow the Use of Postnatal Thymic Epithelial Cells for Thymus Regeneration Approaches

por Bortolomai, Ileana, Sandri, Monica, Draghici, Elena, Fontana, Elena, Campodoni, Elisabetta, Marcovecchio, Genni Enza, Ferrua, Francesca, Perani, Laura, Spinelli, Antonello, Canu, Tamara, Catucci, Marco, Di Tomaso, Tiziano, Sergi Sergi, Lucia, Esposito, Antonio, Lombardo, Angelo, Naldini, Luigi, Tampieri, Anna, Hollander, Georg A., Villa, Anna, Bosticardo, Marita
Publicado 2019

Targeted gene therapy and cell reprogramming in Fanconi anemia

por Rio, Paula, Baños, Rocio, Lombardo, Angelo, Quintana-Bustamante, Oscar, Alvarez, Lara, Garate, Zita, Genovese, Pietro, Almarza, Elena, Valeri, Antonio, Díez, Begoña, Navarro, Susana, Torres, Yaima, Trujillo, Juan P, Murillas, Rodolfo, Segovia, Jose C, Samper, Enrique, Surralles, Jordi, Gregory, Philip D, Holmes, Michael C, Naldini, Luigi, Bueren, Juan A
Publicado 2014

DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes

por Giordano, Anna Maria Sole, Luciani, Marco, Gatto, Francesca, Abou Alezz, Monah, Beghè, Chiara, Della Volpe, Lucrezia, Migliara, Alessandro, Valsoni, Sara, Genua, Marco, Dzieciatkowska, Monika, Frati, Giacomo, Tahraoui-Bories, Julie, Giliani, Silvia Clara, Orcesi, Simona, Fazzi, Elisa, Ostuni, Renato, D’Alessandro, Angelo, Di Micco, Raffaella, Merelli, Ivan, Lombardo, Angelo, Reijns, Martin A.M., Gromak, Natalia, Gritti, Angela, Kajaste-Rudnitski, Anna
Publicado 2022