The p75 neurotrophin receptor is expressed by adult mouse dentate progenitor cells and regulates neuronal and non-neuronal cell genesis

por Bernabeu, Ramon O, Longo, Frank M
Publicado 2010

Restoration of motor learning in a mouse model of Rett syndrome following long-term treatment with a novel small-molecule activator of TrkB

por Adams, Ian, Yang, Tao, Longo, Frank M., Katz, David M.
Publicado 2020

Modulation of the p75 neurotrophin receptor suppresses age-related basal forebrain cholinergic neuron degeneration

por Xie, Youmei, Meeker, Rick B., Massa, Stephen M., Longo, Frank M.
Publicado 2019

Partial Activation of TrkB Receptors Corrects Interneuronal Calcium Channel Dysfunction and Reduces Epileptogenic Activity in Neocortex following Injury

por Gu, Feng, Parada, Isabel, Yang, Tao, Longo, Frank M, Prince, David A
Publicado 2020

Chronic partial TrkB activation reduces seizures and mortality in a mouse model of Dravet syndrome

por Gu, Feng, Parada, Isabel, Yang, Tao, Longo, Frank M., Prince, David A.
Publicado 2022

Small molecule modulation of the p75 neurotrophin receptor inhibits multiple amyloid beta-induced tau pathologies

por Yang, Tao, Tran, Kevin C., Zeng, Anne Y., Massa, Stephen M., Longo, Frank M.
Publicado 2020

Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice

por Yang, Tao, Liu, Harry, Tran, Kevin C., Leng, Albert, Massa, Stephen M., Longo, Frank M.
Publicado 2020

A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice

por Li, Wei, Bellot-Saez, Alba, Phillips, Mary L., Yang, Tao, Longo, Frank M., Pozzo-Miller, Lucas
Publicado 2017

Modulation of p75(NTR) on Mesenchymal Stem Cells Increases Their Vascular Protection in Retinal Ischemia-Reperfusion Mouse Model

por Elshaer, Sally L., Park, Hang-soo, Pearson, Laura, Hill, William D., Longo, Frank M., El-Remessy, Azza B.
Publicado 2021

A Small Molecule p75(NTR) Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression

por Simmons, Danielle A., Knowles, Juliet K., Belichenko, Nadia P., Banerjee, Gargi, Finkle, Carly, Massa, Stephen M., Longo, Frank M.
Publicado 2014

Thy1-hAPP(Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function

por Faizi, Mehrdad, Bader, Patrick L, Saw, Nay, Nguyen, Thuy-Vi V, Beraki, Simret, Wyss-Coray, Tony, Longo, Frank M, Shamloo, Mehrdad
Publicado 2012

Nerve Growth Factor Pathobiology During the Progression of Alzheimer’s Disease

por Mufson, Elliott J., Counts, Scott E., Ginsberg, Stephen D., Mahady, Laura, Perez, Sylvia E., Massa, Stephen M., Longo, Frank M., Ikonomovic, Milos D.
Publicado 2019

TSPO–PET imaging using [(18)F]PBR06 is a potential translatable biomarker for treatment response in Huntington’s disease: preclinical evidence with the p75(NTR) ligand LM11A-31

por Simmons, Danielle A, James, Michelle L, Belichenko, Nadia P, Semaan, Sarah, Condon, Christina, Kuan, Jason, Shuhendler, Adam J, Miao, Zheng, Chin, Frederick T, Longo, Frank M
Publicado 2018

Alzheimer’s associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia

por Nguyen, Thuy-Vi V., Hayes, Megan, Zbesko, Jacob C., Frye, Jennifer B., Congrove, Nicole R., Belichenko, Nadia P., McKay, Brian S., Longo, Frank M., Doyle, Kristian P.
Publicado 2018

Myeloid deficiency of the intrinsic clock protein BMAL1 accelerates cognitive aging by disrupting microglial synaptic pruning

por Iweka, Chinyere Agbaegbu, Seigneur, Erica, Hernandez, Amira Latif, Paredes, Sur Herrera, Cabrera, Mica, Blacher, Eran, Pasternak, Connie Tsai, Longo, Frank M., de Lecea, Luis, Andreasson, Katrin I.
Publicado 2023

A small molecule p75(NTR) ligand normalizes signalling and reduces Huntington’s disease phenotypes in R6/2 and BACHD mice

por Simmons, Danielle A., Belichenko, Nadia P., Ford, Ellen C., Semaan, Sarah, Monbureau, Marie, Aiyaswamy, Sruti, Holman, Cameron M., Condon, Christina, Shamloo, Mehrdad, Massa, Stephen M., Longo, Frank M.
Publicado 2016

Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington’s Disease: Preclinical Evidence with the p75(NTR) Ligand LM11A-31

por Simmons, Danielle A., Mills, Brian D., Butler III, Robert R., Kuan, Jason, McHugh, Tyne L. M., Akers, Carolyn, Zhou, James, Syriani, Wassim, Grouban, Maged, Zeineh, Michael, Longo, Frank M.
Publicado 2021

Small Molecule, Non-Peptide p75(NTR) Ligands Inhibit Aβ-Induced Neurodegeneration and Synaptic Impairment

por Yang, Tao, Knowles, Juliet K., Lu, Qun, Zhang, Hong, Arancio, Ottavio, Moore, Laura A., Chang, Timothy, Wang, Qian, Andreasson, Katrin, Rajadas, Jayakumar, Fuller, Gerald G., Xie, Youmei, Massa, Stephen M., Longo, Frank M.
Publicado 2008

[(18)F]GE-180 PET Detects Reduced Microglia Activation After LM11A-31 Therapy in a Mouse Model of Alzheimer's Disease

por James, Michelle L., Belichenko, Nadia P., Shuhendler, Adam J., Hoehne, Aileen, Andrews, Lauren E., Condon, Christina, Nguyen, Thuy-Vi V., Reiser, Vladimer, Jones, Paul, Trigg, William, Rao, Jianghong, Gambhir, Sanjiv S., Longo, Frank M.
Publicado 2017

Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts

por Zbesko, Jacob C., Nguyen, Thuy-Vi V., Yang, Tao, Frye, Jennifer Beischel, Hussain, Omar, Hayes, Megan, Chung, Amanda, Day, W. Anthony, Stepanovic, Kristina, Krumberger, Maj, Mona, Justine, Longo, Frank M., Doyle, Kristian P.
Publicado 2018