Insightful Backbone Modifications Preventing Proteolytic Degradation of Neurotensin Analogs Improve NTS1-Induced Protective Hypothermia

por Previti, Santo, Vivancos, Mélanie, Rémond, Emmanuelle, Beaulieu, Sabrina, Longpré, Jean-Michel, Ballet, Steven, Sarret, Philippe, Cavelier, Florine
Publicado 2020

Mechanistic insights into the role of the chemokine CCL2/CCR2 axis in dorsal root ganglia to peripheral inflammation and pain hypersensitivity

por Dansereau, Marc-André, Midavaine, Élora, Bégin-Lavallée, Valérie, Belkouch, Mounir, Beaudet, Nicolas, Longpré, Jean-Michel, Mélik-Parsadaniantz, Stéphane, Sarret, Philippe
Publicado 2021

Functional inhibition of chemokine receptor CCR2 by dicer-substrate-siRNA prevents pain development

por Bégin-Lavallée, Valérie, Midavaine, Élora, Dansereau, Marc-André, Tétreault, Pascal, Longpré, Jean-Michel, Jacobi, Ashley M, Rose, Scott D, Behlke, Mark A, Beaudet, Nicolas, Sarret, Philippe
Publicado 2016

Dichotomic effects of clinically used drugs on tumor growth, bone remodeling and pain management

por André Barrière, David, Midavaine, Élora, Doré-Savard, Louis, Kirby, Karyn, Tremblay, Luc, Beaudoin, Jean-François, Beaudet, Nicolas, Longpré, Jean-Michel, Lecomte, Roger, Lepage, Martin, Sarret, Philippe
Publicado 2019

Publisher Correction: Dichotomic effects of clinically used drugs on tumor growth, bone remodeling and pain management

por Barrière, David André, Midavaine, Élora, Doré-Savard, Louis, Kirby, Karyn, Tremblay, Luc, Beaudoin, Jean-François, Beaudet, Nicolas, Longpré, Jean-Michel, Lecomte, Roger, Lepage, Martin, Sarret, Philippe
Publicado 2020

Combination of high-fat/high-fructose diet and low-dose streptozotocin to model long-term type-2 diabetes complications

por Barrière, David André, Noll, Christophe, Roussy, Geneviève, Lizotte, Farah, Kessai, Anissa, Kirby, Karyn, Belleville, Karine, Beaudet, Nicolas, Longpré, Jean-Michel, Carpentier, André C., Geraldes, Pedro, Sarret, Philippe
Publicado 2018

Identification of N-[(5-{[(4-Methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a Neurotensin-like Nonpeptide Compound Selective for the N...

por Thomas, James B., Giddings, Angela M., Wiethe, Robert W., Olepu, Srinivas, Warner, Keith R., Sarret, Philippe, Gendron, Louis, Longpre, Jean-Michel, Zhang, Yanan, Runyon, Scott P., Gilmour, Brian P.
Publicado 2014

Identification of 1-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane Carboxylic Acid as a Selective Nonpeptide Neurotensin Receptor Type 2 Compo...

por Thomas, James B., Giddings, Angela M., Wiethe, Robert W., Olepu, Srinivas, Warner, Keith R., Sarret, Philippe, Gendron, Louis, Longpre, Jean-Michel, Zhang, Yanan, Runyon, Scott P., Gilmour, Brian P.
Publicado 2014

Structure-Based Virtual Screening of Ultra-Large Library Yields Potent Antagonists for a Lipid GPCR

por Sadybekov, Arman A., Brouillette, Rebecca L., Marin, Egor, Sadybekov, Anastasiia V., Luginina, Aleksandra, Gusach, Anastasiia, Mishin, Alexey, Besserer-Offroy, Élie, Longpré, Jean-Michel, Borshchevskiy, Valentin, Cherezov, Vadim, Sarret, Philippe, Katritch, Vsevolod
Publicado 2020

Elabela Protects Spontaneously Hypertensive Rats From Hypertension and Cardiorenal Dysfunctions Exacerbated by Dietary High-Salt Intake

por Sainsily, Xavier, Coquerel, David, Giguère, Hugo, Dumont, Lauralyne, Tran, Kien, Noll, Christophe, Ionescu, Andrei L., Côté, Jérôme, Longpré, Jean-Michel, Carpentier, André, Marsault, Éric, Lesur, Olivier, Sarret, Philippe, Auger-Messier, Mannix
Publicado 2021

Data set describing the in vitro biological activity of JMV2009, a novel silylated neurotensin(8–13) analog

por Besserer-Offroy, Élie, Tétreault, Pascal, Brouillette, Rebecca L, René, Adeline, Murza, Alexandre, Fanelli, Roberto, Kirby, Karyn, Parent, Alexandre, Dubuc, Isabelle, Beaudet, Nicolas, Côté, Jérôme, Longpré, Jean-Michel, Martinez, Jean, Cavelier, Florine, Sarret, Philippe
Publicado 2020

Signal profiling of the β(1)AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β(1)AR and β(2)AR

por Lukasheva, Viktoriya, Devost, Dominic, Le Gouill, Christian, Namkung, Yoon, Martin, Ryan D., Longpré, Jean-Michel, Amraei, Mohammad, Shinjo, Yuji, Hogue, Mireille, Lagacé, Monique, Breton, Billy, Aoki, Junken, Tanny, Jason C., Laporte, Stéphane A., Pineyro, Graciela, Inoue, Asuka, Bouvier, Michel, Hébert, Terence E.
Publicado 2020

Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors

por Gusach, Anastasiia, Luginina, Aleksandra, Marin, Egor, Brouillette, Rebecca L., Besserer-Offroy, Élie, Longpré, Jean-Michel, Ishchenko, Andrii, Popov, Petr, Patel, Nilkanth, Fujimoto, Taku, Maruyama, Toru, Stauch, Benjamin, Ergasheva, Margarita, Romanovskaia, Daria, Stepko, Anastasiia, Kovalev, Kirill, Shevtsov, Mikhail, Gordeliy, Valentin, Han, Gye Won, Katritch, Vsevolod, Borshchevskiy, Valentin, Sarret, Philippe, Mishin, Alexey, Cherezov, Vadim
Publicado 2019

Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs

por Luginina, Aleksandra, Gusach, Anastasiia, Marin, Egor, Mishin, Alexey, Brouillette, Rebecca, Popov, Petr, Shiriaeva, Anna, Besserer-Offroy, Élie, Longpré, Jean-Michel, Lyapina, Elizaveta, Ishchenko, Andrii, Patel, Nilkanth, Polovinkin, Vitaly, Safronova, Nadezhda, Bogorodskiy, Andrey, Edelweiss, Evelina, Hu, Hao, Weierstall, Uwe, Liu, Wei, Batyuk, Alexander, Gordeliy, Valentin, Han, Gye Won, Sarret, Philippe, Katritch, Vsevolod, Borshchevskiy, Valentin, Cherezov, Vadim
Publicado 2019