Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity

por Green, Simon R., Wilson, Caroline, Eadsforth, Thomas C., Punekar, Avinash S., Tamaki, Fabio K., Wood, Gavin, Caldwell, Nicola, Forte, Barbara, Norcross, Neil R., Kiczun, Michael, Post, John M., Lopez-Román, Eva Maria, Engelhart, Curtis A., Lukac, Iva, Zuccotto, Fabio, Epemolu, Ola, Boshoff, Helena I. M., Schnappinger, Dirk, Walpole, Chris, Gilbert, Ian H., Read, Kevin D., Wyatt, Paul G., Baragaña, Beatriz
Publicado 2023

Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery

por Rebollo-Lopez, María Jose, Lelièvre, Joël, Alvarez-Gomez, Daniel, Castro-Pichel, Julia, Martínez-Jiménez, Francisco, Papadatos, George, Kumar, Vinod, Colmenarejo, Gonzalo, Mugumbate, Grace, Hurle, Mark, Barroso, Vanessa, Young, Rob J., Martinez-Hoyos, María, González del Río, Rubén, Bates, Robert H., Lopez-Roman, Eva Maria, Mendoza-Losana, Alfonso, Brown, James R., Alvarez-Ruiz, Emilio, Marti-Renom, Marc A., Overington, John P., Cammack, Nicholas, Ballell, Lluís, Barros-Aguire, David
Publicado 2015

Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target

por Wilson, Caroline, Ray, Peter, Zuccotto, Fabio, Hernandez, Jorge, Aggarwal, Anup, Mackenzie, Claire, Caldwell, Nicola, Taylor, Malcolm, Huggett, Margaret, Mathieson, Michael, Murugesan, Dinakaran, Smith, Alasdair, Davis, Susan, Cocco, Mattia, Parai, Maloy K., Acharya, Arjun, Tamaki, Fabio, Scullion, Paul, Epemolu, Ola, Riley, Jennifer, Stojanovski, Laste, Lopez-Román, Eva Maria, Torres-Gómez, Pedro Alfonso, Toledo, Ana Maria, Guijarro-Lopez, Laura, Camino, Isabel, Engelhart, Curtis A., Schnappinger, Dirk, Massoudi, Lisa M., Lenaerts, Anne, Robertson, Gregory T., Walpole, Chris, Matthews, David, Floyd, David, Sacchettini, James C., Read, Kevin D., Encinas, Lourdes, Bates, Robert H., Green, Simon R., Wyatt, Paul G.
Publicado 2021