Window of opportunity clinical trial designs to study cancer metabolism

por Aroldi, Francesca, Lord, Simon R.
Publicado 2019

Is it still worth pursuing the repurposing of metformin as a cancer therapeutic?

por Lord, Simon R., Harris, Adrian L.
Publicado 2023

Obesity: a perfect storm for carcinogenesis

por Harris, Benjamin H. L., Macaulay, Valentine M., Harris, David A., Klenerman, Paul, Karpe, Fredrik, Lord, Simon R., Harris, Adrian L., Buffa, Francesca M.
Publicado 2022

Dual Erb B Inhibition in Oesophago-gastric Cancer (DEBIOC): A phase I dose escalating safety study and randomised dose expansion of AZD8931 in combination with oxaliplatin and cape...

por Thomas, Anne, Virdee, Pradeep S., Eatock, Martin, Lord, Simon R., Falk, Stephen, Anthoney, D. Alan, Turkington, Richard C., Goff, Matthew, Elhussein, Leena, Collins, Linda, Love, Sharon, Moschandreas, Joanna, Middleton, Mark R.
Publicado 2020

Phase 1b study of berzosertib and cisplatin in patients with advanced triple-negative breast cancer

por Telli, Melinda L., Tolaney, Sara M., Shapiro, Geoffrey I., Middleton, Mark, Lord, Simon R., Arkenau, Hendrik Tobias, Tutt, Andrew, Abramson, Vandana, Dean, Emma, Haddad, Tufia C., Wesolowski, Robert, Ferrer-Playan, Jordi, Goddemeier, Thomas, Grombacher, Thomas, Dong, Jennifer, Fleuranceau-Morel, Patricia, Diaz-Padilla, Ivan, Plummer, Ruth
Publicado 2022

Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib

por Coombes, R. C., Howell, Sacha, Lord, Simon R., Kenny, Laura, Mansi, Janine, Mitri, Zahi, Palmieri, Carlo, Chap, Linnea I., Richards, Paul, Gradishar, William, Sardesai, Sagar, Melear, Jason, O’Shaughnessy, Joyce, Ward, Patrick, Chalasani, Pavani, Arkenau, Tobias, Baird, Richard D., Jeselsohn, Rinath, Ali, Simak, Clack, Glen, Bahl, Ashwani, McIntosh, Stuart, Krebs, Matthew G.
Publicado 2023

Author Correction: Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib

por Coombes, R. C., Howell, Sacha, Lord, Simon R., Kenny, Laura, Mansi, Janine, Mitri, Zahi, Palmieri, Carlo, Chap, Linnea I., Richards, Paul, Gradishar, William, Sardesai, Sagar, Melear, Jason, O’Shaughnessy, Joyce, Ward, Patrick, Chalasani, Pavani, Arkenau, Tobias, Baird, Richard D., Jeselsohn, Rinath, Ali, Simak, Clack, Glen, Bahl, Ashwani, McIntosh, Stuart, Krebs, Matthew G.
Publicado 2023

Transcriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin

por Lord, Simon R., Collins, Jennifer M., Cheng, Wei-Chen, Haider, Syed, Wigfield, Simon, Gaude, Edoardo, Fielding, Barbara A., Pinnick, Katherine E., Harjes, Ulrike, Segaran, Ashvina, Jha, Pooja, Hoefler, Gerald, Pollak, Michael N., Thompson, Alastair M., Roy, Pankaj G., English, Ruth., Adams, Rosie F., Frezza, Christian, Buffa, Francesca M., Karpe, Fredrik, Harris, Adrian L.
Publicado 2019

Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer

por Lord, Simon R., Cheng, Wei-Chen, Liu, Dan, Gaude, Edoardo, Haider, Syed, Metcalf, Tom, Patel, Neel, Teoh, Eugene J., Gleeson, Fergus, Bradley, Kevin, Wigfield, Simon, Zois, Christos, McGowan, Daniel R., Ah-See, Mei-Lin, Thompson, Alastair M., Sharma, Anand, Bidaut, Luc, Pollak, Michael, Roy, Pankaj G., Karpe, Fredrik, James, Tim, English, Ruth, Adams, Rosie F., Campo, Leticia, Ayers, Lisa, Snell, Cameron, Roxanis, Ioannis, Frezza, Christian, Fenwick, John D., Buffa, Francesca M., Harris, Adrian L.
Publicado 2018

Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases

por Pagnamenta, Alistair T., Camps, Carme, Giacopuzzi, Edoardo, Taylor, John M., Hashim, Mona, Calpena, Eduardo, Kaisaki, Pamela J., Hashimoto, Akiko, Yu, Jing, Sanders, Edward, Schwessinger, Ron, Hughes, Jim R., Lunter, Gerton, Dreau, Helene, Ferla, Matteo, Lange, Lukas, Kesim, Yesim, Ragoussis, Vassilis, Vavoulis, Dimitrios V., Allroggen, Holger, Ansorge, Olaf, Babbs, Christian, Banka, Siddharth, Baños-Piñero, Benito, Beeson, David, Ben-Ami, Tal, Bennett, David L., Bento, Celeste, Blair, Edward, Brasch-Andersen, Charlotte, Bull, Katherine R., Cario, Holger, Cilliers, Deirdre, Conti, Valerio, Davies, E. Graham, Dhalla, Fatima, Dacal, Beatriz Diez, Dong, Yin, Dunford, James E., Guerrini, Renzo, Harris, Adrian L., Hartley, Jane, Hollander, Georg, Javaid, Kassim, Kane, Maureen, Kelly, Deirdre, Kelly, Dominic, Knight, Samantha J. L., Kreins, Alexandra Y., Kvikstad, Erika M., Langman, Craig B., Lester, Tracy, Lines, Kate E., Lord, Simon R., Lu, Xin, Mansour, Sahar, Manzur, Adnan, Maroofian, Reza, Marsden, Brian, Mason, Joanne, McGowan, Simon J., Mei, Davide, Mlcochova, Hana, Murakami, Yoshiko, Németh, Andrea H., Okoli, Steven, Ormondroyd, Elizabeth, Ousager, Lilian Bomme, Palace, Jacqueline, Patel, Smita Y., Pentony, Melissa M., Pugh, Chris, Rad, Aboulfazl, Ramesh, Archana, Riva, Simone G., Roberts, Irene, Roy, Noémi, Salminen, Outi, Schilling, Kyleen D., Scott, Caroline, Sen, Arjune, Smith, Conrad, Stevenson, Mark, Thakker, Rajesh V., Twigg, Stephen R. F., Uhlig, Holm H., van Wijk, Richard, Vona, Barbara, Wall, Steven, Wang, Jing, Watkins, Hugh, Zak, Jaroslav, Schuh, Anna H., Kini, Usha, Wilkie, Andrew O. M., Popitsch, Niko, Taylor, Jenny C.
Publicado 2023