Drug Repurposing for Viral Infectious Diseases: How Far Are We?

por Mercorelli, Beatrice, Palù, Giorgio, Loregian, Arianna
Publicado 2018

Early inhibitors of human cytomegalovirus: State-of-art and therapeutic perspectives

por Mercorelli, Beatrice, Lembo, David, Palù, Giorgio, Loregian, Arianna
Publicado 2011

Drug Repurposing Campaigns for Human Cytomegalovirus Identify a Natural Compound Targeting the Immediate-Early 2 (IE2) Protein: A Comment on “The Natural Flavonoid Compound Degueli...

por Mercorelli, Beatrice, Luganini, Anna, Palù, Giorgio, Gribaudo, Giorgio, Loregian, Arianna
Publicado 2019

Targeted Disruption of E6/p53 Binding Exerts Broad Activity and Synergism with Paclitaxel and Topotecan against HPV-Transformed Cancer Cells

por Celegato, Marta, Messa, Lorenzo, Bertagnin, Chiara, Mercorelli, Beatrice, Loregian, Arianna
Publicado 2021

Binding parameters and thermodynamics of the interaction of the human cytomegalovirus DNA polymerase accessory protein, UL44, with DNA: implications for the processivity mechanism

por Loregian, Arianna, Sinigalia, Elisa, Mercorelli, Beatrice, Palù, Giorgio, Coen, Donald M.
Publicado 2007

A quantitative LumiFluo assay to test inhibitory compounds blocking p53 degradation induced by human papillomavirus oncoprotein E6 in living cells

por Messa, Lorenzo, Celegato, Marta, Bertagnin, Chiara, Mercorelli, Beatrice, Nannetti, Giulio, Palù, Giorgio, Loregian, Arianna
Publicado 2018

Divide et impera: An In Silico Screening Targeting HCMV ppUL44 Processivity Factor Homodimerization Identifies Small Molecules Inhibiting Viral Replication

por Ghassabian, Hanieh, Falchi, Federico, Timmoneri, Martina, Mercorelli, Beatrice, Loregian, Arianna, Palù, Giorgio, Alvisi, Gualtiero
Publicado 2021

Regulated Transport into the Nucleus of Herpesviridae DNA Replication Core Proteins

por Gualtiero, Alvisi, Jans, David A., Camozzi, Daria, Avanzi, Simone, Loregian, Arianna, Ripalti, Alessandro, Palù, Giorgio
Publicado 2013

The Dimeric Form of HPV16 E6 Is Crucial to Drive YAP/TAZ Upregulation through the Targeting of hScrib

por Messa, Lorenzo, Celegato, Marta, Bertagnin, Chiara, Mercorelli, Beatrice, Alvisi, Gualtiero, Banks, Lawrence, Palù, Giorgio, Loregian, Arianna
Publicado 2021

Indomethacin-based PROTACs as pan-coronavirus antiviral agents

por Desantis, Jenny, Mercorelli, Beatrice, Celegato, Marta, Croci, Federico, Bazzacco, Alessandro, Baroni, Massimo, Siragusa, Lydia, Cruciani, Gabriele, Loregian, Arianna, Goracci, Laura
Publicado 2021

Contemporary medicinal chemistry strategies for the discovery and optimization of influenza inhibitors targeting vRNP constituent proteins

por Hou, Lingxin, Zhang, Ying, Ju, Han, Cherukupalli, Srinivasulu, Jia, Ruifang, Zhang, Jian, Huang, Bing, Loregian, Arianna, Liu, Xinyong, Zhan, Peng
Publicado 2022

Discovery of novel SARS-CoV-2 inhibitors targeting the main protease M(pro) by virtual screenings and hit optimization

por Mercorelli, Beatrice, Desantis, Jenny, Celegato, Marta, Bazzacco, Alessandro, Siragusa, Lydia, Benedetti, Paolo, Eleuteri, Michela, Croci, Federico, Cruciani, Gabriele, Goracci, Laura, Loregian, Arianna
Publicado 2022

The Human Cytomegalovirus DNA Polymerase Processivity Factor UL44 Is Modified by SUMO in a DNA-Dependent Manner

por Sinigalia, Elisa, Alvisi, Gualtiero, Segré, Chiara V., Mercorelli, Beatrice, Muratore, Giulia, Winkler, Michael, Hsiao, He-Hsuan, Urlaub, Henning, Ripalti, Alessandro, Chiocca, Susanna, Palù, Giorgio, Loregian, Arianna
Publicado 2012

A Point Mutation in a Herpesvirus Polymerase Determines Neuropathogenicity

por Goodman, Laura B, Loregian, Arianna, Perkins, Gillian A, Nugent, Josie, Buckles, Elizabeth L, Mercorelli, Beatrice, Kydd, Julia H, Palù, Giorgio, Smith, Ken C, Osterrieder, Nikolaus, Davis-Poynter, Nicholas
Publicado 2007

A novel N-heterocycles substituted oseltamivir derivatives as potent inhibitors of influenza virus neuraminidase: discovery, synthesis and biological evaluation

por Zhang, Jiwei, Liu, Chuanfeng, Jia, Ruifang, Zhang, Xujie, Zhang, Jian, Bertagnin, Chiara, Bonomini, Anna, Guizzo, Laura, Jiang, Yuanmin, Jia, Huinan, Jia, Shuzhen, Ma, Xiuli, Loregian, Arianna, Huang, Bing, Zhan, Peng, Liu, Xinyong
Publicado 2023

Discovery of Novel Boron-Containing N-Substituted Oseltamivir Derivatives as Anti-Influenza A Virus Agents for Overcoming N1-H274Y Oseltamivir-Resistant

por Jia, Ruifang, Zhang, Jiwei, Zhang, Jian, Bertagnin, Chiara, Bonomini, Anna, Guizzo, Laura, Gao, Zhen, Ji, Xiangkai, Li, Zhuo, Liu, Chuanfeng, Ju, Han, Ma, Xiuli, Loregian, Arianna, Huang, Bing, Zhan, Peng, Liu, Xinyong
Publicado 2022

Small-Molecule Inhibitor of Flaviviral NS3-NS5 Interaction with Broad-Spectrum Activity and Efficacy In Vivo

por Celegato, Marta, Sturlese, Mattia, Vasconcelos Costa, Vivian, Trevisan, Marta, Lallo Dias, Angélica Samer, Souza Passos, Ingredy Beatriz, Queiroz-Junior, Celso Martins, Messa, Lorenzo, Favaro, Annagiulia, Moro, Stefano, Teixeira, Mauro Martins, Loregian, Arianna, Mercorelli, Beatrice
Publicado 2023

Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase

por Massari, Serena, Bertagnin, Chiara, Pismataro, Maria Chiara, Donnadio, Anna, Nannetti, Giulio, Felicetti, Tommaso, Di Bona, Stefano, Nizi, Maria Giulia, Tensi, Leonardo, Manfroni, Giuseppe, Loza, Maria Isabel, Sabatini, Stefano, Cecchetti, Violetta, Brea, Jose, Goracci, Laura, Loregian, Arianna, Tabarrini, Oriana
Publicado 2021

Author Correction: Suppression of a SARS-CoV-2 outbreak in the Italian municipality of Vo’

por Lavezzo, Enrico, Franchin, Elisa, Ciavarella, Constanze, Cuomo-Dannenburg, Gina, Barzon, Luisa, Del Vecchio, Claudia, Rossi, Lucia, Manganelli, Riccardo, Loregian, Arianna, Navarin, Nicolò, Abate, Davide, Sciro, Manuela, Merigliano, Stefano, De Canale, Ettore, Vanuzzo, Maria Cristina, Besutti, Valeria, Saluzzo, Francesca, Onelia, Francesco, Pacenti, Monia, Parisi, Saverio G., Carretta, Giovanni, Donato, Daniele, Flor, Luciano, Cocchio, Silvia, Masi, Giulia, Sperduti, Alessandro, Cattarino, Lorenzo, Salvador, Renato, Nicoletti, Michele, Caldart, Federico, Castelli, Gioele, Nieddu, Eleonora, Labella, Beatrice, Fava, Ludovico, Drigo, Matteo, Gaythorpe, Katy A. M., Brazzale, Alessandra R., Toppo, Stefano, Trevisan, Marta, Baldo, Vincenzo, Donnelly, Christl A., Ferguson, Neil M., Dorigatti, Ilaria, Crisanti, Andrea
Publicado 2021