Inhibition of MYC by the SMARCB1 tumor suppressor

por Weissmiller, April M., Wang, Jing, Lorey, Shelly L., Howard, Gregory C., Martinez, Ernest, Liu, Qi, Tansey, William P.
Publicado 2019

A common functional consequence of tumor-derived mutations within c-MYC

por Chakraborty, Abhishek A., Scuoppo, Claudio, Dey, Soumyadeep, Thomas, Lance R., Lorey, Shelly L., Lowe, Scott W., Tansey, William. P.
Publicado 2014

B Cell Responses to HIV Antigen Are a Potent Correlate of Viremia in HIV-1 Infection and Improve with PD-1 Blockade

por Nicholas, Katherine J., Zern, Emily K., Barnett, Louise, Smith, Rita M., Lorey, Shelly L., Copeland, Courtney A., Sadagopal, Shanmugalakshmi, Kalams, Spyros A.
Publicado 2013

Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance

por Thomas, Lance R., Adams, Clare M., Wang, Jing, Weissmiller, April M., Creighton, Joy, Lorey, Shelly L., Liu, Qi, Fesik, Stephen W., Eischen, Christine M., Tansey, William P.
Publicado 2019

WIN site inhibition disrupts a subset of WDR5 function

por Siladi, Andrew J., Wang, Jing, Florian, Andrea C., Thomas, Lance R., Creighton, Joy H., Matlock, Brittany K., Flaherty, David K., Lorey, Shelly L., Howard, Gregory C., Fesik, Stephen W., Weissmiller, April M., Liu, Qi, Tansey, William P.
Publicado 2022

MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

por Popay, Tessa M, Wang, Jing, Adams, Clare M, Howard, Gregory Caleb, Codreanu, Simona G, Sherrod, Stacy D, McLean, John A, Thomas, Lance R, Lorey, Shelly L, Machida, Yuichi J, Weissmiller, April M, Eischen, Christine M, Liu, Qi, Tansey, William P
Publicado 2021

Multiple interactions of the oncoprotein transcription factor MYC with the SWI/SNF chromatin remodeler

por Woodley, Chase M., Romer, Alexander S., Wang, Jing, Guarnaccia, Alissa D., Elion, David L., Maxwell, Jack N., Guerrazzi, Kiana, McCann, Tyler S., Popay, Tessa M., Matlock, Brittany K., Flaherty, David K., Lorey, Shelly L., Liu, Qi, Tansey, William P., Weissmiller, April M.
Publicado 2021

WDR5 is a conserved regulator of protein synthesis gene expression

por Bryan, Audra F, Wang, Jing, Howard, Gregory C, Guarnaccia, Alissa D, Woodley, Chase M, Aho, Erin R, Rellinger, Eric J, Matlock, Brittany K, Flaherty, David K, Lorey, Shelly L, Chung, Dai H, Fesik, Stephen W, Liu, Qi, Weissmiller, April M, Tansey, William P
Publicado 2020

Synergistic action of WDR5 and HDM2 inhibitors in SMARCB1-deficient cancer cells

por Florian, Andrea C, Woodley, Chase M, Wang, Jing, Grieb, Brian C, Slota, Macey J, Guerrazzi, Kiana, Hsu, Chih-Yuan, Matlock, Brittany K, Flaherty, David K, Lorey, Shelly L, Fesik, Stephen W, Howard, Gregory C, Liu, Qi, Weissmiller, April M, Tansey, William P
Publicado 2022

Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

por Howard, Gregory C., Wang, Jing, Rose, Kristie Lindsey, Patel, Purvi, Tsui, Tina, Florian, Andrea C., Lorey, Shelly L., Grieb, Brian C., Smith, Brianna N., Slota, Macey J., Reynolds, Elizabeth M., Goswami, Soumita, Savona, Michael R., Lee, Taekyu, Fesik, Stephen W., Liu, Qi, Tansey, William P.
Publicado 2023

Impact of WIN site inhibitor on the WDR5 interactome

por Guarnaccia, Alissa D., Rose, Kristie L., Wang, Jing, Zhao, Bin, Popay, Tessa M., Wang, Christina E., Guerrazzi, Kiana, Hill, Salisha, Woodley, Chase M., Hansen, Tyler J., Lorey, Shelly L., Shaw, J. Grace, Payne, William G., Weissmiller, April M., Olejniczak, Edward T., Fesik, Stephen W., Liu, Qi, Tansey, William P.
Publicado 2021

Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models

por Teuscher, Kevin B., Chowdhury, Somenath, Meyers, Kenneth M., Tian, Jianhua, Sai, Jiqing, Van Meveren, Mayme, South, Taylor M., Sensintaffar, John L., Rietz, Tyson A., Goswami, Soumita, Wang, Jing, Grieb, Brian C., Lorey, Shelly L., Howard, Gregory C., Liu, Qi, Moore, William J., Stott, Gordon M., Tansey, William P., Lee, Taekyu, Fesik, Stephen W.
Publicado 2022

Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity

por Aho, Erin R., Wang, Jing, Gogliotti, Rocco D., Howard, Gregory C., Phan, Jason, Acharya, Pankaj, Macdonald, Jonathan D., Cheng, Ken, Lorey, Shelly L., Lu, Bin, Wenzel, Sabine, Foshage, Audra M., Alvarado, Joseph, Wang, Feng, Shaw, J. Grace, Zhao, Bin, Weissmiller, April M., Thomas, Lance R., Vakoc, Christopher R., Hall, Matthew D., Hiebert, Scott W., Liu, Qi, Stauffer, Shaun R., Fesik, Stephen W., Tansey, William P.
Publicado 2019