Crystal structures of thiamine monophosphate kinase from Acinetobacter baumannii in complex with substrates and products

por Sullivan, Amy H., Dranow, David M., Horanyi, Peter S., Lorimer, Donald D., Edwards, Thomas E., Abendroth, Jan
Publicado 2019

Structure of acid deoxyribonuclease

por Varela-Ramirez, Armando, Abendroth, Jan, Mejia, Adrian A., Phan, Isabelle Q., Lorimer, Donald D., Edwards, Thomas E., Aguilera, Renato J.
Publicado 2017

Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis

por Begley, Darren W., Edwards, Thomas E., Raymond, Amy C., Smith, Eric R., Hartley, Robert C., Abendroth, Jan, Sankaran, Banumathi, Lorimer, Donald D., Myler, Peter J., Staker, Bart L., Stewart, Lance J.
Publicado 2011

Ligand co-crystallization of aminoacyl-tRNA synthetases from infectious disease organisms

por Moen, Spencer O., Edwards, Thomas E., Dranow, David M., Clifton, Matthew C., Sankaran, Banumathi, Van Voorhis, Wesley C., Sharma, Amit, Manoil, Colin, Staker, Bart L., Myler, Peter J., Lorimer, Donald D.
Publicado 2017

Structural characterisation of hemagglutinin from seven Influenza A H1N1 strains reveal diversity in the C05 antibody recognition site

por Ghafoori, Seyed Mohammad, Petersen, Gayle F., Conrady, Deborah G., Calhoun, Brandy M., Stigliano, Matthew Z. Z., Baydo, Ruth O., Grice, Rena, Abendroth, Jan, Lorimer, Donald D., Edwards, Thomas E., Forwood, Jade K.
Publicado 2023

Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit

por Armour, Brianna L., Barnes, Steve R., Moen, Spencer O., Smith, Eric, Raymond, Amy C., Fairman, James W., Stewart, Lance J., Staker, Bart L., Begley, Darren W., Edwards, Thomas E., Lorimer, Donald D.
Publicado 2013

Structural characterization of a Type B chloramphenicol acetyltransferase from the emerging pathogen Elizabethkingia anophelis NUHP1

por Ghafoori, Seyed Mohammad, Robles, Alyssa M., Arada, Angelika M., Shirmast, Paniz, Dranow, David M., Mayclin, Stephen J., Lorimer, Donald D., Myler, Peter J., Edwards, Thomas E., Kuhn, Misty L., Forwood, Jade K.
Publicado 2021

Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors

por Haft, Daniel H., Pierce, Phillip G., Mayclin, Stephen J., Sullivan, Amy, Gardberg, Anna S., Abendroth, Jan, Begley, Darren W., Phan, Isabelle Q., Staker, Bart L., Myler, Peter J., Marathias, Vasilios M., Lorimer, Donald D., Edwards, Thomas E.
Publicado 2017

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase

por Hewitt, Stephen Nakazawa, Dranow, David M., Horst, Benjamin G., Abendroth, Jan A., Forte, Barbara, Hallyburton, Irene, Jansen, Chimed, Baragaña, Beatriz, Choi, Ryan, Rivas, Kasey L., Hulverson, Matthew A., Dumais, Mitchell, Edwards, Thomas E., Lorimer, Donald D., Fairlamb, Alan H., Gray, David W., Read, Kevin D., Lehane, Adele M., Kirk, Kiaran, Myler, Peter J., Wernimont, Amy, Walpole, Chris, Stacy, Robin, Barrett, Lynn K., Gilbert, Ian H., Van Voorhis, Wesley C.
Publicado 2016

Broad-spectrum in vitro activity of macrophage infectivity potentiator inhibitors against Gram-negative bacteria and Leishmania major

por Iwasaki, Jua, Lorimer, Donald D., Vivoli-Vega, Mirella, Kibble, Emily A., Peacock, Christopher S., Abendroth, Jan, Mayclin, Stephen J., Dranow, David M., Pierce, Phillip G., Fox, David, Lewis, Maria, Bzdyl, Nicole M., Kristensen, Sofie S., Inglis, Timothy J. J., Kahler, Charlene M., Bond, Charles S., Hasenkopf, Anja, Seufert, Florian, Schmitz, Jens, Marshall, Laura E., Scott, Andrew E., Norville, Isobel H., Myler, Peter J., Holzgrabe, Ulrike, Harmer, Nicholas J., Sarkar-Tyson, Mitali
Publicado 2022

Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba

por Tillery, Logan, Barrett, Kayleigh, Goldstein, Jenna, Lassner, Jared W., Osterhout, Bram, Tran, Nathan L., Xu, Lily, Young, Ryan M., Craig, Justin, Chun, Ian, Dranow, David M., Abendroth, Jan, Delker, Silvia L., Davies, Douglas R., Mayclin, Stephen J., Calhoun, Brandy, Bolejack, Madison J., Staker, Bart, Subramanian, Sandhya, Phan, Isabelle, Lorimer, Donald D., Myler, Peter J., Edwards, Thomas E., Kyle, Dennis E., Rice, Christopher A., Morris, James C., Leahy, James W., Manetsch, Roman, Barrett, Lynn K., Smith, Craig L., Van Voorhis, Wesley C.
Publicado 2021

Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362

por Lowe, Martin A., Cardenas, Alvaro, Valentin, Jean-Pierre, Zhu, Zhaoning, Abendroth, Jan, Castro, Jose L., Class, Reiner, Delaunois, Annie, Fleurance, Renaud, Gerets, Helga, Gryshkova, Vitalina, King, Lloyd, Lorimer, Donald D., MacCoss, Malcolm, Rowley, Julian H., Rosseels, Marie-Luce, Royer, Leandro, Taylor, Richard D., Wong, Melanie, Zaccheo, Oliver, Chavan, Vishal P., Ghule, Gokul A., Tapkir, Bapusaheb K., Burrows, Jeremy N., Duffey, Maëlle, Rottmann, Matthias, Wittlin, Sergio, Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Striepen, Josefine, Fairhurst, Kate J., Yeo, Tomas, Fidock, David A., Cowman, Alan F., Favuzza, Paola, Crespo-Fernandez, Benigno, Gamo, Francisco Javier, Goldberg, Daniel E., Soldati-Favre, Dominique, Laleu, Benoît, de Haro, Teresa
Publicado 2022

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

por Baragaña, Beatriz, Forte, Barbara, Choi, Ryan, Nakazawa Hewitt, Stephen, Bueren-Calabuig, Juan A., Pisco, João Pedro, Peet, Caroline, Dranow, David M., Robinson, David A., Jansen, Chimed, Norcross, Neil R., Vinayak, Sumiti, Anderson, Mark, Brooks, Carrie F., Cooper, Caitlin A., Damerow, Sebastian, Delves, Michael, Dowers, Karen, Duffy, James, Edwards, Thomas E., Hallyburton, Irene, Horst, Benjamin G., Hulverson, Matthew A., Ferguson, Liam, Jiménez-Díaz, María Belén, Jumani, Rajiv S., Lorimer, Donald D., Love, Melissa S., Maher, Steven, Matthews, Holly, McNamara, Case W., Miller, Peter, O’Neill, Sandra, Ojo, Kayode K., Osuna-Cabello, Maria, Pinto, Erika, Post, John, Riley, Jennifer, Rottmann, Matthias, Sanz, Laura M., Scullion, Paul, Sharma, Arvind, Shepherd, Sharon M., Shishikura, Yoko, Simeons, Frederick R. C., Stebbins, Erin E., Stojanovski, Laste, Straschil, Ursula, Tamaki, Fabio K., Tamjar, Jevgenia, Torrie, Leah S., Vantaux, Amélie, Witkowski, Benoît, Wittlin, Sergio, Yogavel, Manickam, Zuccotto, Fabio, Angulo-Barturen, Iñigo, Sinden, Robert, Baum, Jake, Gamo, Francisco-Javier, Mäser, Pascal, Kyle, Dennis E., Winzeler, Elizabeth A., Myler, Peter J., Wyatt, Paul G., Floyd, David, Matthews, David, Sharma, Amit, Striepen, Boris, Huston, Christopher D., Gray, David W., Fairlamb, Alan H., Pisliakov, Andrei V., Walpole, Chris, Read, Kevin D., Van Voorhis, Wesley C., Gilbert, Ian H.
Publicado 2019