Maximizing the return on taxpayers' investments in fundamental biomedical research

por Lorsch, Jon R.
Publicado 2015

Yeast Ded1 promotes 48S translation pre-initiation complex assembly in an mRNA-specific and eIF4F-dependent manner

por Gupta, Neha, Lorsch, Jon R, Hinnebusch, Alan G
Publicado 2018

Developing a culture of safety in biomedical research training

por Bond, Michelle R., Gammie, Alison E., Lorsch, Jon R.
Publicado 2020

Distinct interactions of eIF4A and eIF4E with RNA helicase Ded1 stimulate translation in vivo

por Gulay, Suna, Gupta, Neha, Lorsch, Jon R, Hinnebusch, Alan G
Publicado 2020

eIF1 discriminates against suboptimal initiation sites to prevent excessive uORF translation genome-wide

por Zhou, Fujun, Zhang, Hongen, Kulkarni, Shardul D., Lorsch, Jon R., Hinnebusch, Alan G.
Publicado 2020

Transcriptome-wide analysis of the function of Ded1 in translation preinitiation complex assembly in a reconstituted in vitro system

por Zhou, Fujun, Bocetti, Julie M., Hou, Meizhen, Qin, Daoming, Hinnebusch, Alan G., Lorsch, Jon R.
Publicado 2023

Active yeast ribosome preparation using monolithic anion exchange chromatography

por Munoz, Antonio M., Yourik, Paul, Rajagopal, Vaishnavi, Nanda, Jagpreet S., Lorsch, Jon R., Walker, Sarah E.
Publicado 2016

Yeast eIF4A enhances recruitment of mRNAs regardless of their structural complexity

por Yourik, Paul, Aitken, Colin Echeverría, Zhou, Fujun, Gupta, Neha, Hinnebusch, Alan G, Lorsch, Jon R
Publicado 2017

Increasing Clinician-Scientist Workforce Diversity through the National Institute of General Medical Sciences’ Medical Scientist Training Program

por Gammie, Alison E., Dorsey, Travis F., Epou, Sabrina F., Miklos, Andrew C., Lorsch, Jon R.
Publicado 2022

Temperature-dependent regulation of upstream open reading frame translation in S. cerevisiae

por Kulkarni, Shardul D., Zhou, Fujun, Sen, Neelam Dabas, Zhang, Hongen, Hinnebusch, Alan G., Lorsch, Jon R.
Publicado 2019

Initiation Factor eIF2γ Promotes eIF2–GTP–Met-tRNA(i)(Met) Ternary Complex Binding to the 40S Ribosome

por Shin, Byung-Sik, Kim, Joo-Ran, Walker, Sarah E., Dong, Jinsheng, Lorsch, Jon R., Dever, Thomas E.
Publicado 2011

Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating P(i) release and conformational transitions of the preinitiation comple...

por Saini, Adesh K., Nanda, Jagpreet S., Martin-Marcos, Pilar, Dong, Jinsheng, Zhang, Fan, Bhardwaj, Monika, Lorsch, Jon R., Hinnebusch, Alan G.
Publicado 2014

Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating Pi release and conformational transitions of the preinitiation complex

por Saini, Adesh K., Nanda, Jagpreet S., Martin-Marcos, Pilar, Dong, Jinsheng, Zhang, Fan, Bhardwaj, Monika, Lorsch, Jon R., Hinnebusch, Alan G.
Publicado 2015

Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex

por Llácer, Jose L., Hussain, Tanweer, Marler, Laura, Aitken, Colin Echeverría, Thakur, Anil, Lorsch, Jon R., Hinnebusch, Alan G., Ramakrishnan, V.
Publicado 2015

Conserved residues in yeast initiator tRNA calibrate initiation accuracy by regulating preinitiation complex stability at the start codon

por Dong, Jinsheng, Munoz, Antonio, Kolitz, Sarah E., Saini, Adesh K., Chiu, Wen-ling, Rahman, Hafsa, Lorsch, Jon R., Hinnebusch, Alan G.
Publicado 2014

Eukaryotic translation initiation factor 3 plays distinct roles at the mRNA entry and exit channels of the ribosomal preinitiation complex

por Aitken, Colin Echeverría, Beznosková, Petra, Vlčkova, Vladislava, Chiu, Wen-Ling, Zhou, Fujun, Valášek, Leoš Shivaya, Hinnebusch, Alan G, Lorsch, Jon R
Publicado 2016

Structural Changes Enable Start Codon Recognition by the Eukaryotic Translation Initiation Complex

por Hussain, Tanweer, Llácer, Jose L., Fernández, Israel S., Munoz, Antonio, Martin-Marcos, Pilar, Savva, Christos G., Lorsch, Jon R., Hinnebusch, Alan G., Ramakrishnan, V.
Publicado 2014

Enhanced eIF1 binding to the 40S ribosome impedes conformational rearrangements of the preinitiation complex and elevates initiation accuracy

por Martin-Marcos, Pilar, Nanda, Jagpreet S., Luna, Rafael E., Zhang, Fan, Saini, Adesh K., Cherkasova, Vera A., Wagner, Gerhard, Lorsch, Jon R., Hinnebusch, Alan G.
Publicado 2014

Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition

por Llácer, Jose Luis, Hussain, Tanweer, Saini, Adesh K, Nanda, Jagpreet Singh, Kaur, Sukhvir, Gordiyenko, Yuliya, Kumar, Rakesh, Hinnebusch, Alan G, Lorsch, Jon R, Ramakrishnan, V
Publicado 2018

eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast

por Martin-Marcos, Pilar, Zhou, Fujun, Karunasiri, Charm, Zhang, Fan, Dong, Jinsheng, Nanda, Jagpreet, Kulkarni, Shardul D, Sen, Neelam Dabas, Tamame, Mercedes, Zeschnigk, Michael, Lorsch, Jon R, Hinnebusch, Alan G
Publicado 2017