Predicting locations of cryptic pockets from single protein structures using the PocketMiner graph neural network

por Meller, Artur, Ward, Michael, Borowsky, Jonathan, Kshirsagar, Meghana, Lotthammer, Jeffrey M., Oviedo, Felipe, Ferres, Juan Lavista, Bowman, Gregory R.
Publicado 2023

Divergent Molecular Phenotypes in Point Mutations at the Same Residue in Beta-Myosin Heavy Chain Lead to Distinct Cardiomyopathies

por Lehman, Sarah J., Meller, Artur, Solieva, Shahlo O., Lotthammer, Jeffrey M., Greenberg, Lina, Langer, Stephen J., Greenberg, Michael J., Tardiff, Jil C., Bowman, Gregory R., Leinwand, Leslie
Publicado 2023

Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains

por Meller, Artur, Lotthammer, Jeffrey M, Smith, Louis G, Novak, Borna, Lee, Lindsey A, Kuhn, Catherine C, Greenberg, Lina, Leinwand, Leslie A, Greenberg, Michael J, Bowman, Gregory R
Publicado 2023

Functional divergence of the sarcomeric myosin, MYH7b, supports species-specific biological roles

por Lee, Lindsey A., Barrick, Samantha K., Meller, Artur, Walklate, Jonathan, Lotthammer, Jeffrey M., Tay, Jian Wei, Stump, W. Tom, Bowman, Gregory, Geeves, Michael A., Greenberg, Michael J., Leinwand, Leslie A.
Publicado 2022

Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

por Giese, Arnaud P. J., Weng, Wei-Hsiang, Kindt, Katie S., Chang, Hui Ho Vanessa, Montgomery, Jonathan S., Ratzan, Evan M., Beirl, Alisha J., Rivera, Roberto Aponte, Lotthammer, Jeffrey M., Walujkar, Sanket, Foster, Mark P., Zobeiri, Omid A., Holt, Jeffrey R., Riazuddin, Saima, Cullen, Kathleen E., Sotomayor, Marcos, Ahmed, Zubair M.
Publicado 2023