Adaptation of formal concept analysis for the systematic exploration of structure-activity and structure-selectivity relationships

por Lounkine, Eugen, Bajorath, Jürgen
Publicado 2010

Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets

por Maciejewski, Mateusz, Lounkine, Eugen, Whitebread, Steven, Farmer, Pierre, DuMouchel, William, Shoichet, Brian K, Urban, Laszlo
Publicado 2017

Large Scale Prediction and Testing of Drug Activity on Side-Effect Targets

por Lounkine, Eugen, Keiser, Michael J., Whitebread, Steven, Mikhailov, Dmitri, Hamon, Jacques, Jenkins, Jeremy, Lavan, Paul, Weber, Eckhard, Doak, Allison K., Côté, Serge, Shoichet, Brian K., Urban, Laszlo
Publicado 2012

Gene-signature-derived IC(50)s/EC(50)s reflect the potency of causative upstream targets and downstream phenotypes

por Renner, Steffen, Bergsdorf, Christian, Bouhelal, Rochdi, Koziczak-Holbro, Magdalena, Amati, Andrea Marco, Techer-Etienne, Valerie, Flotte, Ludivine, Reymann, Nicole, Kapur, Karen, Hoersch, Sebastian, Oakeley, Edward James, Schuffenhauer, Ansgar, Gubler, Hanspeter, Lounkine, Eugen, Farmer, Pierre
Publicado 2020