A comparison of the ability of the human IgG1 allotypes G1m3 and G1m1,17 to stimulate T-cell responses from allotype matched and mismatched donors

por Webster, Carl I., Bryson, Christine J., Cloake, Edward A., Jones, Tim D., Austin, Mark J., Karle, Anette C., Spindeldreher, Sebastian, Lowe, David C., Baker, Matthew P.
Publicado 2016

Investigating the Structural Compaction of Biomolecules Upon Transition to the Gas-Phase Using ESI-TWIMS-MS

por Devine, Paul W. A., Fisher, Henry C., Calabrese, Antonio N., Whelan, Fiona, Higazi, Daniel R., Potts, Jennifer R., Lowe, David C., Radford, Sheena E., Ashcroft, Alison E.
Publicado 2017

An in vivo platform to select and evolve aggregation-resistant proteins

por Ebo, Jessica S., Saunders, Janet C., Devine, Paul W. A., Gordon, Alice M., Warwick, Amy S., Schiffrin, Bob, Chin, Stacey E., England, Elizabeth, Button, James D., Lloyd, Christopher, Bond, Nicholas J., Ashcroft, Alison E., Radford, Sheena E., Lowe, David C., Brockwell, David J.
Publicado 2020

Affinity maturation of a novel antagonistic human monoclonal antibody with a long V(H) CDR3 targeting the Class A GPCR formyl-peptide receptor 1

por Douthwaite, Julie A, Sridharan, Sudharsan, Huntington, Catherine, Hammersley, Jayne, Marwood, Rose, Hakulinen, Jonna K, Ek, Margareta, Sjögren, Tove, Rider, David, Privezentzev, Cyril, Seaman, Jonathan C, Cariuk, Peter, Knights, Vikki, Young, Joyce, Wilkinson, Trevor, Sleeman, Matthew, Finch, Donna K, Lowe, David C, Vaughan, Tristan J
Publicado 2014

Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1

por Vousden, Katherine A., Lundqvist, Tomas, Popovic, Bojana, Naiman, Brian, Carruthers, Alan M., Newton, Philip, Johnson, Daniel J. D., Pomowski, Anja, Wilkinson, Trevor, Dufner, Patrick, de Mendez, Isabelle, Mallinder, Philip R., Murray, Clare, Strain, Martin, Connor, Jane, Murray, Lynne A., Sleeman, Matthew A., Lowe, David C., Huntington, James A., Vaughan, Tristan J.
Publicado 2019

Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction

por England, Elizabeth, Rees, D. Gareth, Scott, Ian Christopher, Carmen, Sara, Chan, Denice T. Y., Chaillan Huntington, Catherine E., Houslay, Kirsty F., Erngren, Teodor, Penney, Mark, Majithiya, Jayesh B., Rapley, Laura, Sims, Dorothy A., Hollins, Claire, Hinchy, Elizabeth C., Strain, Martin D., Kemp, Benjamin P., Corkill, Dominic J., May, Richard D., Vousden, Katherine A., Butler, Robin J., Mustelin, Tomas, Vaughan, Tristan J., Lowe, David C., Colley, Caroline, Cohen, E. Suzanne
Publicado 2023

Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo

por Dobson, Claire L., Devine, Paul W. A., Phillips, Jonathan J., Higazi, Daniel R., Lloyd, Christopher, Popovic, Bojana, Arnold, Joanne, Buchanan, Andrew, Lewis, Arthur, Goodman, Joanne, van der Walle, Christopher F., Thornton, Peter, Vinall, Lisa, Lowne, David, Aagaard, Anna, Olsson, Lise-Lotte, Ridderstad Wollberg, Anna, Welsh, Fraser, Karamanos, Theodoros K., Pashley, Clare L., Iadanza, Matthew G., Ranson, Neil A., Ashcroft, Alison E., Kippen, Alistair D., Vaughan, Tristan J., Radford, Sheena E., Lowe, David C.
Publicado 2016

Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

por Cohen, E. Suzanne, Scott, Ian C., Majithiya, Jayesh B., Rapley, Laura, Kemp, Benjamin P., England, Elizabeth, Rees, D. Gareth, Overed-Sayer, Catherine L., Woods, Joanne, Bond, Nicholas J., Veyssier, Christel Séguy, Embrey, Kevin J., Sims, Dorothy A., Snaith, Michael R., Vousden, Katherine A., Strain, Martin D., Chan, Denice T. Y., Carmen, Sara, Huntington, Catherine E., Flavell, Liz, Xu, Jianqing, Popovic, Bojana, Brightling, Christopher E., Vaughan, Tristan J., Butler, Robin, Lowe, David C., Higazi, Daniel R., Corkill, Dominic J., May, Richard D., Sleeman, Matthew A., Mustelin, Tomas
Publicado 2015

The INNs and outs of antibody nonproprietary names

por Jones, Tim D., Carter, Paul J., Plückthun, Andreas, Vásquez, Max, Holgate, Robert G.E., Hötzel, Isidro, Popplewell, Andrew G., Parren, Paul W.H.I., Enzelberger, Markus, Rademaker, Hendrik J., Clark, Michael R., Lowe, David C., Dahiyat, Bassil I., Smith, Victoria, Lambert, John M., Wu, Herren, Reilly, Mary, Haurum, John S., Dübel, Stefan, Huston, James S., Schirrmann, Thomas, Janssen, Richard A.J., Steegmaier, Martin, Gross, Jane A., Bradbury, Andrew R.M., Burton, Dennis R., Dimitrov, Dimiter S., Chester, Kerry A., Glennie, Martin J., Davies, Julian, Walker, Adam, Martin, Steve, McCafferty, John, Baker, Matthew P.
Publicado 2015