Cytosolic malate dehydrogenase activity helps support glycolysis in actively proliferating cells and cancer

por Hanse, Eric A, Ruan, Chunhai, Kachman, Maureen, Wang, Dongyu, Lowman, Xazmin H, Kelekar, Ameeta
Publicado 2017

IKKβ activates p53 to promote cancer cell adaptation to glutamine deprivation

por Ishak Gabra, Mari B., Yang, Ying, Lowman, Xazmin H., Reid, Michael A., Tran, Thai Q., Kong, Mei
Publicado 2018

Tumor-associated mutant p53 promotes cancer cell survival upon glutamine deprivation through p21 induction

por Tran, Thai Q., Lowman, Xazmin H., Reid, Michael A., Mendez-Dorantes, Carlos, Pan, Min, Yang, Ying, Kong, Mei
Publicado 2016

Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression via Histone Modification and Prevents Cancer-Induced Cachexia

por Ruiz, Bryan I., Lowman, Xazmin H., Yang, Ying, Fan, Qi, Wang, Tianhong, Wu, Hongmei, Hanse, Eric A., Kong, Mei
Publicado 2023

Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes

por Tran, Thai Q., Ishak Gabra, Mari B., Lowman, Xazmin H., Yang, Ying, Reid, Michael A., Pan, Min, O’Connor, Timothy R., Kong, Mei
Publicado 2017

IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3

por Reid, Michael A., Lowman, Xazmin H., Pan, Min, Tran, Thai Q., Warmoes, Marc O., Ishak Gabra, Mari B., Yang, Ying, Locasale, Jason W., Kong, Mei
Publicado 2016

Vemurafenib resistance reprograms melanoma cells towards glutamine dependence

por Hernandez-Davies, Jenny E, Tran, Thai Q, Reid, Michael A, Rosales, Kimberly R, Lowman, Xazmin H, Pan, Min, Moriceau, Gatien, Yang, Ying, Wu, Jun, Lo, Roger S, Kong, Mei
Publicado 2015

MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1

por Yang, Ying, Ishak Gabra, Mari B., Hanse, Eric A., Lowman, Xazmin H., Tran, Thai Q., Li, Haiqing, Milman, Neta, Liu, Juan, Reid, Michael A., Locasale, Jason W., Gil, Ziv, Kong, Mei
Publicado 2019

Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth

por Ishak Gabra, Mari B., Yang, Ying, Li, Haiqing, Senapati, Parijat, Hanse, Eric A., Lowman, Xazmin H., Tran, Thai Q., Zhang, Lishi, Doan, Linda T., Xu, Xiangdong, Schones, Dustin E., Fruman, David A., Kong, Mei
Publicado 2020