Comparative analysis of PD‐1 target engagement of dostarlimab and pembrolizumab in advanced solid tumors using ex vivo IL‐2 stimulation data

por Austin, Daren, Melhem, Murad, Gandhi, Yash, Lu, Sharon, Visser, Sandra
Publicado 2022

Population pharmacokinetics and exposure–response of anti‐programmed cell death protein‐1 monoclonal antibody dostarlimab in advanced solid tumours

por Melhem, Murad, Hanze, Eva, Lu, Sharon, Alskär, Oskar, Visser, Sandra, Gandhi, Yash
Publicado 2022

Effects of rolapitant administered orally on the pharmacokinetics of dextromethorphan (CYP2D6), tolbutamide (CYP2C9), omeprazole (CYP2C19), efavirenz (CYP2B6), and repaglinide (CYP...

por Wang, Jing, Zhang, Zhi-Yi, Lu, Sharon, Powers, Dan, Kansra, Vikram, Wang, Xiaodong
Publicado 2018

Pathologic response after neoadjuvant chemotherapy predicts locoregional control in patients with triple negative breast cancer

por Chen, Victor E., Gillespie, Erin F., Zakeri, Kaveh, Murphy, James D., Yashar, Catheryn M., Lu, Sharon, Einck, John P.
Publicado 2017

Positive mental health in psychotherapy: a qualitative study from psychotherapists’ perspectives

por Chang, Sherilyn, Sambasivam, Rajeswari, Seow, Esmond, Subramaniam, Mythily, Ashok Assudani, Hanita, Tan, Geoffrey Chern-Yee, Lu, Sharon Huixian, Vaingankar, Janhavi Ajit
Publicado 2022

A Randomised Controlled Trial of Clinician-Guided Internet-Based Cognitive Behavioural Therapy for Depressed Patients in Singapore

por Lu, Sharon H. X., Assudani, Hanita A., Kwek, Tammie R. R., Ng, Shaun W. H., Teoh, Trisha E. L., Tan, Geoffrey C. Y.
Publicado 2021

“We Are All Trying to Find a Way to Help Ourselves”: A Look at Self-Help Strategies Among Psychotherapy Clients

por Chang, Sherilyn, Sambasivam, Rajeswari, Seow, Esmond, Tan, Geoffrey Chern-Yee, Lu, Sharon Huixian, Assudani, Hanita, Chong, Siow Ann, Subramaniam, Mythily, Vaingankar, Janhavi Ajit
Publicado 2021

An Integrated Analysis of Dostarlimab Immunogenicity

por Lu, Sharon, Bowsher, Ronald R., Clancy, Amanda, Rosen, Amy, Zhang, Mingxuan, Yang, Ying, Koeck, Kathleen, Gao, Minggeng, Potocka, Elizabeth, Guo, Wei, Jen, Kai Yu, Im, Ellie, Milton, Ashley
Publicado 2021

Safety, antitumor activity, and pharmacokinetics of dostarlimab, an anti-PD-1, in patients with advanced solid tumors: a dose–escalation phase 1 trial

por Patnaik, Amita, Weiss, Glen J., Rasco, Drew W., Blaydorn, Lisa, Mirabella, Amy, Beeram, Murali, Guo, Wei, Lu, Sharon, Danaee, Hadi, McEachern, Kristen, Im, Ellie, Sachdev, Jasgit C.
Publicado 2021

Preclinical characterization of dostarlimab, a therapeutic anti-PD-1 antibody with potent activity to enhance immune function in in vitro cellular assays and in vivo animal models

por Kumar, Sujatha, Ghosh, Srimoyee, Sharma, Geeta, Wang, Zebin, Kehry, Marilyn R., Marino, Margaret H., Neben, Tamlyn Y., Lu, Sharon, Luo, Shouqi, Roberts, Simon, Ramaswamy, Sridhar, Danaee, Hadi, Jenkins, David
Publicado 2021

IOLite: phase 1b trial of doublet/triplet combinations of dostarlimab with niraparib, carboplatin–paclitaxel, with or without bevacizumab in patients with advanced cancer

por Yap, Timothy A, Bessudo, Alberto, Hamilton, Erika, Sachdev, Jasgit, Patel, Manish R, Rodon, Jordi, Evilevitch, Lena, Duncan, Meghan, Guo, Wei, Kumar, Sujatha, Lu, Sharon, Dezube, Bruce J, Gabrail, Nashat
Publicado 2022

JASPER: Phase 2 trial of first‐line niraparib plus pembrolizumab in patients with advanced non–small cell lung cancer

por Ramalingam, Suresh S., Thara, Eddie, Awad, Mark M., Dowlati, Afshin, Haque, Basir, Stinchcombe, Thomas E., Dy, Grace K., Spigel, David R., Lu, Sharon, Iyer Singh, Nithya, Tang, Yongqiang, Teslenko, Iryna, Iannotti, Nicholas
Publicado 2021

A phase 1, open-label, dose-escalation trial of oral TSR-011 in patients with advanced solid tumours and lymphomas

por Lin, Chia-Chi, Arkenau, Hendrik-Tobias, Lu, Sharon, Sachdev, Jasgit, de Castro Carpeño, Javier, Mita, Monica, Dziadziuszko, Rafal, Su, Wu-Chou, Bobilev, Dmitri, Hughes, Lorraine, Chan, Jian, Zhang, Zhi-Yi, Weiss, Glen J.
Publicado 2019

White matter microstructure in late middle-age: Effects of apolipoprotein E4 and parental family history of Alzheimer's disease

por Adluru, Nagesh, Destiche, Daniel J., Lu, Sharon Yuan-Fu, Doran, Samuel T., Birdsill, Alex C., Melah, Kelsey E., Okonkwo, Ozioma C., Alexander, Andrew L., Dowling, N. Maritza, Johnson, Sterling C., Sager, Mark A., Bendlin, Barbara B.
Publicado 2014