Molecular pharmacology in a simple model system: Implicating MAP kinase and phosphoinositide signalling in bipolar disorder

por Ludtmann, Marthe H.R., Boeckeler, Katrina, Williams, Robin S.B.
Publicado 2011

LRRK2 deficiency induced mitochondrial Ca(2+) efflux inhibition can be rescued by Na(+)/Ca(2+)/Li(+) exchanger upregulation

por Ludtmann, Marthe H. R., Kostic, Marko, Horne, Amy, Gandhi, Sonia, Sekler, Israel, Abramov, Andrey Y.
Publicado 2019

PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons

por Kostic, Marko, Ludtmann, Marthe H.R., Bading, Hilmar, Hershfinkel, Michal, Steer, Erin, Chu, Charleen T., Abramov, Andrey Y., Sekler, Israel
Publicado 2015

Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons

por Ludtmann, Marthe H. R., Arber, Charles, Bartolome, Fernando, de Vicente, Macarena, Preza, Elisavet, Carro, Eva, Houlden, Henry, Gandhi, Sonia, Wray, Selina, Abramov, Andrey Y.
Publicado 2017

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

por Jadiya, Pooja, Kolmetzky, Devin W., Tomar, Dhanendra, Di Meco, Antonio, Lombardi, Alyssa A., Lambert, Jonathan P., Luongo, Timothy S., Ludtmann, Marthe H., Praticò, Domenico, Elrod, John W.
Publicado 2019

Hypoxia signaling controls postnatal changes in cardiac mitochondrial morphology and function

por Neary, Marianne T., Ng, Keat-Eng, Ludtmann, Marthe H.R., Hall, Andrew R., Piotrowska, Izabela, Ong, Sang-Bing, Hausenloy, Derek J., Mohun, Timothy J., Abramov, Andrey Y., Breckenridge, Ross A.
Publicado 2014

Ca(2+) is a key factor in α-synuclein-induced neurotoxicity

por Angelova, Plamena R., Ludtmann, Marthe H. R., Horrocks, Mathew H., Negoda, Alexander, Cremades, Nunilo, Klenerman, David, Dobson, Christopher M., Wood, Nicholas W., Pavlov, Evgeny V., Gandhi, Sonia, Abramov, Andrey Y.
Publicado 2016

Loss of PINK1 Increases the Heart's Vulnerability to Ischemia-Reperfusion Injury

por Siddall, Hilary K., Yellon, Derek M., Ong, Sang-Bing, Mukherjee, Uma A., Burke, Niall, Hall, Andrew R., Angelova, Plamena R., Ludtmann, Marthe H. R., Deas, Emma, Davidson, Sean M., Mocanu, Mihaela M., Hausenloy, Derek J.
Publicado 2013

Correction: Loss of PINK1 Increases the Heart's Vulnerability to Ischemia-Reperfusion Injury

por Siddall, Hilary K., Yellon, Derek M., Ong, Sang-Bing, Mukherjee, Uma A., Burke, Niall, Hall, Andrew R., Angelova, Plamena R., Ludtmann, Marthe H. R., Deas, Emma, Davidson, Sean M., Mocanu, Mihaela M., Hausenloy, Derek J.
Publicado 2013

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

por Deas, Emma, Cremades, Nunilo, Angelova, Plamena R., Ludtmann, Marthe H.R., Yao, Zhi, Chen, Serene, Horrocks, Mathew H., Banushi, Blerida, Little, Daniel, Devine, Michael J., Gissen, Paul, Klenerman, David, Dobson, Christopher M., Wood, Nicholas W., Gandhi, Sonia, Abramov, Andrey Y.
Publicado 2016

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species

por Iljina, Marija, Hong, Liu, Horrocks, Mathew H., Ludtmann, Marthe H., Choi, Minee L., Hughes, Craig D., Ruggeri, Francesco S., Guilliams, Tim, Buell, Alexander K., Lee, Ji-Eun, Gandhi, Sonia, Lee, Steven F., Bryant, Clare E., Vendruscolo, Michele, Knowles, Tuomas P. J., Dobson, Christopher M., De Genst, Erwin, Klenerman, David
Publicado 2017

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

por Ludtmann, Marthe H. R., Angelova, Plamena R., Horrocks, Mathew H., Choi, Minee L., Rodrigues, Margarida, Baev, Artyom Y., Berezhnov, Alexey V., Yao, Zhi, Little, Daniel, Banushi, Blerida, Al-Menhali, Afnan Saleh, Ranasinghe, Rohan T., Whiten, Daniel R., Yapom, Ratsuda, Dolt, Karamjit Singh, Devine, Michael J., Gissen, Paul, Kunath, Tilo, Jaganjac, Morana, Pavlov, Evgeny V., Klenerman, David, Abramov, Andrey Y., Gandhi, Sonia
Publicado 2018

Clinical, pathological and functional characterization of riboflavin-responsive neuropathy

por Manole, Andreea, Jaunmuktane, Zane, Hargreaves, Iain, Ludtmann, Marthe H R, Salpietro, Vincenzo, Bello, Oscar D, Pope, Simon, Pandraud, Amelie, Horga, Alejandro, Scalco, Renata S, Li, Abi, Ashokkumar, Balasubramaniem, Lourenço, Charles M, Heales, Simon, Horvath, Rita, Chinnery, Patrick F, Toro, Camilo, Singleton, Andrew B, Jacques, Thomas S, Abramov, Andrey Y, Muntoni, Francesco, Hanna, Michael G, Reilly, Mary M, Revesz, Tamas, Kullmann, Dimitri M, Jepson, James E C, Houlden, Henry
Publicado 2017