Moving pathogen genomics out of the lab and into the clinic: what will it take?

por Luheshi, Leila M., Raza, Sobia, Peacock, Sharon J.
Publicado 2015

The Aggregation and Neurotoxicity of TDP-43 and Its ALS-Associated 25 kDa Fragment Are Differentially Affected by Molecular Chaperones in Drosophila

por Gregory, Jenna M., Barros, Teresa P., Meehan, Sarah, Dobson, Christopher M., Luheshi, Leila M.
Publicado 2012

Structural Reorganisation and Potential Toxicity of Oligomeric Species Formed during the Assembly of Amyloid Fibrils

por Cheon, Mookyung, Chang, Iksoo, Mohanty, Sandipan, Luheshi, Leila M, Dobson, Christopher M, Vendruscolo, Michele, Favrin, Giorgio
Publicado 2007

Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies

por Wacker, Jessica, Rönicke, Raik, Westermann, Martin, Wulff, Melanie, Reymann, Klaus G, Dobson, Christopher M, Horn, Uwe, Crowther, Damian C, Luheshi, Leila M, Fändrich, Marcus
Publicado 2014

Direct Observations of Amyloid β Self-Assembly in Live Cells Provide Insights into Differences in the Kinetics of Aβ(1–40) and Aβ(1–42) Aggregation

por Esbjörner, Elin K., Chan, Fiona, Rees, Eric, Erdelyi, Miklos, Luheshi, Leila M., Bertoncini, Carlos W., Kaminski, Clemens F., Dobson, Christopher M., Kaminski Schierle, Gabriele S.
Publicado 2014

Disease-related amyloidogenic variants of human lysozyme trigger the unfolded protein response and disturb eye development in Drosophila melanogaster

por Kumita, Janet R., Helmfors, Linda, Williams, Jocy, Luheshi, Leila M., Menzer, Linda, Dumoulin, Mireille, Lomas, David A., Crowther, Damian C., Dobson, Christopher M., Brorsson, Ann-Christin
Publicado 2012

Expression in Drosophila of Tandem Amyloid β Peptides Provides Insights into Links between Aggregation and Neurotoxicity

por Speretta, Elena, Jahn, Thomas R., Tartaglia, Gian Gaetano, Favrin, Giorgio, Barros, Teresa P., Imarisio, Sara, Lomas, David A., Luheshi, Leila M., Crowther, Damian C., Dobson, Christopher M.
Publicado 2012

Systematic In Vivo Analysis of the Intrinsic Determinants of Amyloid β Pathogenicity

por Luheshi, Leila M, Tartaglia, Gian Gaetano, Brorsson, Ann-Christin, Pawar, Amol P, Watson, Ian E, Chiti, Fabrizio, Vendruscolo, Michele, Lomas, David A, Dobson, Christopher M, Crowther, Damian C
Publicado 2007

Sequestration of the Aβ Peptide Prevents Toxicity and Promotes Degradation In Vivo

por Luheshi, Leila M., Hoyer, Wolfgang, de Barros, Teresa Pereira, van Dijk Härd, Iris, Brorsson, Ann-Christin, Macao, Bertil, Persson, Cecilia, Crowther, Damian C., Lomas, David A., Ståhl, Stefan, Dobson, Christopher M., Härd, Torleif
Publicado 2010

Clusterin protects neurons against intracellular proteotoxicity

por Gregory, Jenna M., Whiten, Daniel R., Brown, Rebecca A., Barros, Teresa P., Kumita, Janet R., Yerbury, Justin J., Satapathy, Sandeep, McDade, Karina, Smith, Colin, Luheshi, Leila M., Dobson, Christopher M., Wilson, Mark R.
Publicado 2017