Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

por Luk, Kelvin C., Kehm, Victoria M., Zhang, Bin, O’Brien, Patrick, Trojanowski, John Q., Lee, Virginia M.Y.
Publicado 2012

Progressive aggregation of alpha-synuclein and selective degeneration of Lewy inclusion-bearing neurons in a mouse model of parkinsonism

por Osterberg, Valerie R., Spinelli, Kateri J., Weston, Leah J., Luk, Kelvin C., Woltjer, Randall L., Unni, Vivek K.
Publicado 2015

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration

por Tran, Hien T., Chung, Charlotte Hiu-Yan, Iba, Michiyo, Zhang, Bin, Trojanowski, John Q., Luk, Kelvin C., Lee, Virginia M.Y.
Publicado 2014

Snca-GFP Knock-In Mice Reflect Patterns of Endogenous Expression and Pathological Seeding

por Caputo, Anna, Liang, Yuling, Raabe, Tobias D., Lo, Angela, Horvath, Mian, Zhang, Bin, Brown, Hannah J., Stieber, Anna, Luk, Kelvin C.
Publicado 2020

Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease

por Rey, Nolwen L., Steiner, Jennifer A., Maroof, Nazia, Luk, Kelvin C., Madaj, Zachary, Trojanowski, John Q., Lee, Virginia M.-Y., Brundin, Patrik
Publicado 2016

Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term

por Rey, Nolwen L., George, Sonia, Steiner, Jennifer A., Madaj, Zachary, Luk, Kelvin C., Trojanowski, John Q., Lee, Virginia M.-Y., Brundin, Patrik
Publicado 2017

Transmission of α-synucleinopathy from olfactory structures deep into the temporal lobe

por Mason, Daniel M., Nouraei, Negin, Pant, Deepti B., Miner, Kristin M., Hutchison, Daniel F., Luk, Kelvin C., Stolz, John F., Leak, Rehana K.
Publicado 2016

Erratum to: Transmission of α-synucleinopathy from olfactory structures deep into the temporal lobe

por Mason, Daniel M., Nouraei, Negin, Pant, Deepti B., Miner, Kristin M., Hutchison, Daniel F., Luk, Kelvin C., Stolz, John F., Leak, Rehana K.
Publicado 2016

Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD

por Hoban, Deirdre B., Shrigley, Shelby, Mattsson, Bengt, Breger, Ludivine S., Jarl, Ulla, Cardoso, Tiago, Nelander Wahlestedt, Jenny, Luk, Kelvin C., Björklund, Anders, Parmar, Malin
Publicado 2020

α-Synuclein arginylation in the human brain

por Zhao, Jun, Pan, Buyan, Fina, Marie, Huang, Yun, Shimogawa, Marie, Luk, Kelvin C., Rhoades, Elizabeth, Petersson, E. James, Dong, Dawei W., Kashina, Anna
Publicado 2022

α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice

por Uemura, Norihito, Marotta, Nicholas P., Ara, Jahan, Meymand, Emily S., Zhang, Bin, Kameda, Hiroshi, Koike, Masato, Luk, Kelvin C., Trojanowski, John Q., Lee, Virginia M.-Y.
Publicado 2023

Investigating key factors underlying neurodegeneration linked to alpha‐synuclein spread

por Pang, Cindy C. C., Sørensen, Maja H., Lee, Krit, Luk, Kelvin C., Trojanowski, John Q., Lee, Virginia M. Y., Noble, Wendy, Chang, Raymond C. C.
Publicado 2022

Defective Fas expression exacerbates neurotoxicity in a model of Parkinson's disease

por Landau, Anne M., Luk, Kelvin C., Jones, Michelle-Lee, Siegrist-Johnstone, Rosmarie, Young, Yoon Kow, Kouassi, Edouard, Rymar, Vladimir V., Dagher, Alain, Sadikot, Abbas F., Desbarats, Julie
Publicado 2005

Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages

por Haenseler, Walther, Zambon, Federico, Lee, Heyne, Vowles, Jane, Rinaldi, Federica, Duggal, Galbha, Houlden, Henry, Gwinn, Katrina, Wray, Selina, Luk, Kelvin C., Wade-Martins, Richard, James, William S., Cowley, Sally A.
Publicado 2017

Genetic deletion of Polo-like kinase 2 reduces alpha-synuclein serine-129 phosphorylation in presynaptic terminals but not Lewy bodies

por Weston, Leah J., Stackhouse, Teresa L., Spinelli, Kateri J., Boutros, Sydney W., Rose, Elizabeth P., Osterberg, Valerie R., Luk, Kelvin C., Raber, Jacob, Weissman, Tamily A., Unni, Vivek K.
Publicado 2021

Dopaminergic Positron Emission Tomography Imaging in the Alpha‐Synuclein Preformed Fibril Model Reveals Similarities to Early Parkinson's Disease

por Sossi, Vesna, Patterson, Joseph R., McCormick, Siobhan, Kemp, Christopher J., Miller, Kathryn M., Stoll, Anna C., Kuhn, Nathan, Kubik, Michael, Kochmanski, Joseph, Luk, Kelvin C., Sortwell, Caryl E.
Publicado 2022

Poly (ADP-ribose) Interacts With Phosphorylated α-Synuclein in Post Mortem PD Samples

por Puentes, Laura N., Lengyel-Zhand, Zsofia, Lee, Ji Youn, Hsieh, Chia-Ju, Schneider, Mark E., Edwards, Kimberly J., Luk, Kelvin C., Lee, Virginia M.-Y., Trojanowski, John Q., Mach, Robert H.
Publicado 2021

Developmental exposure to the Parkinson’s disease-associated organochlorine pesticide dieldrin alters dopamine neurotransmission in α-synuclein pre-formed fibril (PFF)-injected mic...

por Boyd, Sierra L, Kuhn, Nathan C, Patterson, Joseph R, Stoll, Anna C, Zimmerman, Sydney A, Kolanowski, Mason R, Neubecker, Joseph J, Luk, Kelvin C, Ramsson, Eric S, Sortwell, Caryl E, Bernstein, Alison I
Publicado 2023

Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy

por Schaser, Allison J., Stackhouse, Teresa L., Weston, Leah J., Kerstein, Patrick C., Osterberg, Valerie R., López, Claudia S., Dickson, Dennis W., Luk, Kelvin C., Meshul, Charles K., Woltjer, Randall L., Unni, Vivek K.
Publicado 2020

Striatal Afferent BDNF Is Disrupted by Synucleinopathy and Partially Restored by STN DBS

por Miller, Kathryn M., Patterson, Joseph R., Kochmanski, Joseph, Kemp, Christopher J., Stoll, Anna C., Onyekpe, Christopher U., Cole-Strauss, Allyson, Steece-Collier, Kathy, Howe, Jacob W., Luk, Kelvin C., Sortwell, Caryl E.
Publicado 2021