Development of PBPK model for intra-articular injection in human: methotrexate solution and rheumatoid arthritis case study

por Le Merdy, Maxime, Mullin, Jim, Lukacova, Viera
Publicado 2021

Drug–drug interaction prediction of ziritaxestat using a physiologically based enzyme and transporter pharmacokinetic network interaction model

por Perrier, Jeremy, Gualano, Virginie, Helmer, Eric, Namour, Florence, Lukacova, Viera, Taneja, Amit
Publicado 2023

PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Kidney in Pregnant Subjects and Fetus

por Szeto, Ke Xu, Le Merdy, Maxime, Dupont, Benjamin, Bolger, Michael B., Lukacova, Viera
Publicado 2021

Cellular Quantitative Structure–Activity Relationship (Cell-QSAR): Conceptual Dissection of Receptor Binding and Intracellular Disposition in Antifilarial Activities of Selwood Ant...

por Natesan, Senthil, Wang, Tiansheng, Lukacova, Viera, Bartus, Vladimir, Khandelwal, Akash, Subramaniam, Rajesh, Balaz, Stefan
Publicado 2012

Structure-Based Prediction of Drug Distribution Across the Headgroup and Core Strata of a Phospholipid Bilayer Using Surrogate Phases

por Natesan, Senthil, Lukacova, Viera, Peng, Ming, Subramaniam, Rajesh, Lynch, Sandra, Wang, Zhanbin, Tandlich, Roman, Balaz, Stefan
Publicado 2014

Comprehensive Physiologically Based Pharmacokinetic Model to Assess Drug–Drug Interactions of Phenytoin

por Rodriguez-Vera, Leyanis, Yin, Xuefen, Almoslem, Mohammed, Romahn, Karolin, Cicali, Brian, Lukacova, Viera, Cristofoletti, Rodrigo, Schmidt, Stephan
Publicado 2023

Clinical Ocular Exposure Extrapolation for Ophthalmic Solutions Using PBPK Modeling and Simulation

por Le Merdy, Maxime, AlQaraghuli, Farah, Tan, Ming-Liang, Walenga, Ross, Babiskin, Andrew, Zhao, Liang, Lukacova, Viera
Publicado 2022

Ocular Physiologically Based Pharmacokinetic Modeling for Ointment Formulations

por Le Merdy, Maxime, Spires, Jessica, Lukacova, Viera, Tan, Ming-Liang, Babiskin, Andrew, Xu, Xiaoming, Zhao, Liang, Bolger, Michael B.
Publicado 2020

Leveraging Physiologically Based Modelling to Provide Insights on the Absorption of Paliperidone Extended-Release Formulation under Fed and Fasting Conditions

por Subhani, Saima, Lukacova, Viera, Kim, Chaejin, Rodriguez-Vera, Leyanis, Muniz, Paula, Rodriguez, Monica, Cristofoletti, Rodrigo, Van Os, Sandra, Suarez, Elena, Schmidt, Stephan, Vozmediano, Valvanera
Publicado 2023

PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5′-Diphospho-glucuronosyltransferase Substrates

por Reddy, Micaela B., Bolger, Michael B., Fraczkiewicz, Grace, Del Frari, Laurence, Luo, Laibin, Lukacova, Viera, Mitra, Amitava, Macwan, Joyce S., Mullin, Jim M., Parrott, Neil, Heikkinen, Aki T.
Publicado 2021