New Tools for Syphilis Research

por Lukehart, Sheila A.
Publicado 2018

Antimicrobial resistance in Neisseria gonorrhoeae and Treponema pallidum: evolution, therapeutic challenges and the need to strengthen global surveillance

por Lewis, David A, Lukehart, Sheila A
Publicado 2011

Molecular Studies in Treponema pallidum Evolution: Toward Clarity?

por Mulligan, Connie J., Norris, Steven J., Lukehart, Sheila A.
Publicado 2008

Treponema pallidum subsp. pallidum TP0136 Protein Is Heterogeneous among Isolates and Binds Cellular and Plasma Fibronectin via its NH(2)-Terminal End

por Ke, Wujian, Molini, Barbara J., Lukehart, Sheila A., Giacani, Lorenzo
Publicado 2015

Development of a Multilocus Sequence Typing (MLST) scheme for Treponema pallidum subsp. pertenue: Application to yaws in Lihir Island, Papua New Guinea

por Godornes, Charmie, Giacani, Lorenzo, Barry, Alyssa E., Mitja, Oriol, Lukehart, Sheila A.
Publicado 2017

B-Cell Epitope Mapping of TprC and TprD Variants of Treponema pallidum Subspecies Informs Vaccine Development for Human Treponematoses

por Molini, Barbara, Fernandez, Mark C., Godornes, Charmie, Vorobieva, Anastassia, Lukehart, Sheila A., Giacani, Lorenzo
Publicado 2022

Fine Analysis of Genetic Diversity of the tpr Gene Family among Treponemal Species, Subspecies and Strains

por Centurion-Lara, Arturo, Giacani, Lorenzo, Godornes, Charmie, Molini, Barbara J., Brinck Reid, Tara, Lukehart, Sheila A.
Publicado 2013

Treponema pallidum Major Sheath Protein Homologue Tpr K Is a Target of Opsonic Antibody and the Protective Immune Response

por Centurion-Lara, Arturo, Castro, Christa, Barrett, Lynn, Cameron, Caroline, Mostowfi, Maryam, Van Voorhis, Wesley C., Lukehart, Sheila A.
Publicado 1999

Syphilis? An Unusual Cause of Surgical Emergency in a Human Immunodeficiency Virus-Infected Man

por Bender Ignacio, Rachel A., Koch, Lisa L., Dhanireddy, Shireesha, Charmie Godornes, B., Lukehart, Sheila A., Marrazzo, Jeanne M.
Publicado 2015

Complete Genome Sequence of the Treponema pallidum subsp. pallidum Sea81-4 Strain

por Giacani, Lorenzo, Iverson-Cabral, Stefanie L., King, Jordon C. K., Molini, Barbara J., Lukehart, Sheila A., Centurion-Lara, Arturo
Publicado 2014

Analytical Performance Characteristics of a New Transcription-Mediated Amplification Assay for Treponema pallidum

por Getman, Damon, Lin, Mike, Barakat, Nesreen, Skvoretz, Rhonda, Godornes, Charmie, Swenson, Paul, Nenninger, Ashley, Golden, Matthew R., Lukehart, Sheila A.
Publicado 2021

Footprint of Positive Selection in Treponema pallidum subsp. pallidum Genome Sequences Suggests Adaptive Microevolution of the Syphilis Pathogen

por Giacani, Lorenzo, Chattopadhyay, Sujay, Centurion-Lara, Arturo, Jeffrey, Brendan M., Le, Hoavan T., Molini, Barbara J., Lukehart, Sheila A., Sokurenko, Evgeni V., Rockey, Daniel D.
Publicado 2012

Genomic epidemiology of syphilis reveals independent emergence of macrolide resistance across multiple circulating lineages

por Beale, Mathew A., Marks, Michael, Sahi, Sharon K., Tantalo, Lauren C., Nori, Achyuta V., French, Patrick, Lukehart, Sheila A., Marra, Christina M., Thomson, Nicholas R.
Publicado 2019

Immunization with a tri-antigen syphilis vaccine significantly attenuates chancre development, reduces bacterial load, and inhibits dissemination of Treponema pallidum

por Lukehart, Sheila A., Molini, Barbara, Gomez, Alloysius, Godornes, Charmie, Hof, Rebecca, Fernandez, Mark C., Pitner, Ragan A., Gray, Sean A., Carter, Darrick, Giacani, Lorenzo, Cameron, Caroline E.
Publicado 2022

Macrolide Resistance in Treponema pallidum Correlates With 23S rDNA Mutations in Recently Isolated Clinical Strains

por Molini, Barbara J., Tantalo, Lauren C., Sahi, Sharon K., Rodriguez, Veronica I., Brandt, Stephanie L., Fernandez, Mark C., Godornes, Charmie B., Marra, Christina M., Lukehart, Sheila A.
Publicado 2016

Diagnostics for Yaws Eradication: Insights From Direct Next-Generation Sequencing of Cutaneous Strains of Treponema pallidum

por Marks, Michael, Fookes, Maria, Wagner, Josef, Butcher, Robert, Ghinai, Rosanna, Sokana, Oliver, Sarkodie, Yaw-Adu, Lukehart, Sheila A, Solomon, Anthony W, Mabey, David C W, Thomson, Nicholas
Publicado 2018

Streptococcus pyogenes Is Associated with Idiopathic Cutaneous Ulcers in Children on a Yaws-Endemic Island

por Griesenauer, Brad, González-Beiras, Camila, Fortney, Katherine R., Lin, Huaiying, Gao, Xiang, Godornes, Charmie, Nelson, David E., Katz, Barry P., Lukehart, Sheila A., Mitjà, Oriol, Dong, Qunfeng, Spinola, Stanley M.
Publicado 2021

Longitudinal TprK profiling of in vivo and in vitro-propagated Treponema pallidum subsp. pallidum reveals accumulation of antigenic variants in absence of immune pressure

por Lin, Michelle J., Haynes, Austin M., Addetia, Amin, Lieberman, Nicole A. P., Phung, Quynh, Xie, Hong, Nguyen, Tien V., Molini, Barbara J., Lukehart, Sheila A., Giacani, Lorenzo, Greninger, Alexander L.
Publicado 2021

Re-emergence of yaws after single mass azithromycin treatment followed by targeted treatment: a longitudinal study

por Mitjà, Oriol, Godornes, Charmie, Houinei, Wendy, Kapa, August, Paru, Raymond, Abel, Haina, González-Beiras, Camila, Bieb, Sibauk V., Wangi, James, Barry, Alyssa E., Asiedu, Kingsley, Sanz, Sergi, Bassat, Quique, Lukehart, Sheila A.
Publicado 2018

Haemophilus ducreyi DNA is detectable on the skin of asymptomatic children, flies and fomites in villages of Papua New Guinea

por Houinei, Wendy, Godornes, Charmie, Kapa, August, Knauf, Sascha, Mooring, Eric Q., González-Beiras, Camila, Watup, Ronald, Paru, Raymond, Advent, Paul, Bieb, Sivauk, Sanz, Sergi, Bassat, Quique, Spinola, Stanley M., Lukehart, Sheila A., Mitjà, Oriol
Publicado 2017