The topical study of inhaled drug (salbutamol) delivery in idiopathic pulmonary fibrosis

por Usmani, Omar S., Biddiscombe, Martyn F., Yang, Shuying, Meah, Sally, Oballa, Eunice, Simpson, Juliet K., Fahy, William A., Marshall, Richard P., Lukey, Pauline T., Maher, Toby M.
Publicado 2018

Safety, tolerability and pharmacokinetics of GSK3008348, a novel integrin αvβ6 inhibitor, in healthy participants

por Maden, Charlotte H., Fairman, David, Chalker, Michelle, Costa, Maria J., Fahy, William A., Garman, Nadia, Lukey, Pauline T., Mant, Tim, Parry, Simon, Simpson, Juliet K., Slack, Robert J., Kendrick, Stuart, Marshall, Richard P.
Publicado 2018

Areas of normal pulmonary parenchyma on HRCT exhibit increased FDG PET signal in IPF patients

por Win, Thida, Thomas, Benjamin A., Lambrou, Tryphon, Hutton, Brian F., Screaton, Nicholas J., Porter, Joanna C., Maher, Toby M., Endozo, Raymondo, Shortman, Robert I., Afaq, Asim, Lukey, Pauline, Ell, Peter J., Groves, Ashley M.
Publicado 2013

Preclinical evaluation of [(18)F]FB-A20FMDV2 as a selective marker for measuring α(V)β(6) integrin occupancy using positron emission tomography in rodent lung

por Onega, Mayca, Parker, Christine A., Coello, Christopher, Rizzo, Gaia, Keat, Nicholas, Ramada-Magalhaes, Joaquim, Moz, Sara, Tang, Sac-Pham, Plisson, Christophe, Wells, Lisa, Ashworth, Sharon, Slack, Robert J., Vitulli, Giovanni, Wilson, Frederick J., Gunn, Roger, Lukey, Pauline T., Passchier, Jan
Publicado 2020

Pulmonary (18)F-FDG uptake helps refine current risk stratification in idiopathic pulmonary fibrosis (IPF)

por Win, Thida, Screaton, Nicholas J., Porter, Joanna C., Ganeshan, Balaji, Maher, Toby M., Fraioli, Francesco, Endozo, Raymondo, Shortman, Robert I., Hurrell, Lynn, Holman, Beverley F., Thielemans, Kris, Rashidnasab, Alaleh, Hutton, Brian F., Lukey, Pauline T., Flynn, Aiden, Ell, Peter J., Groves, Ashley M.
Publicado 2018

Clinical quantification of the integrin αvβ6 by [(18)F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study)

por Lukey, Pauline T., Coello, Christopher, Gunn, Roger, Parker, Christine, Wilson, Frederick J., Saleem, Azeem, Garman, Nadia, Costa, Maria, Kendrick, Stuart, Onega, Mayca, Kang’ombe, Arthur R., Listanco, Allan, Davies, James, Ramada-Magalhaes, Joaquim, Moz, Sara, Fahy, William A., Maher, Toby M., Jenkins, Gisli, Passchier, Jan, Marshall, Richard P.
Publicado 2019

Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF

por Mercer, Paul F, Woodcock, Hannah V, Eley, Jessica D, Platé, Manuela, Sulikowski, Michal G, Durrenberger, Pascal F, Franklin, Linda, Nanthakumar, Carmel B, Man, Yim, Genovese, Federica, McAnulty, Robin J, Yang, Shuying, Maher, Toby M, Nicholson, Andrew G, Blanchard, Andy D, Marshall, Richard P, Lukey, Pauline T, Chambers, Rachel C
Publicado 2016

A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvβ...

por Maher, Toby M., Simpson, Juliet K., Porter, Joanna C., Wilson, Frederick J., Chan, Robert, Eames, Rhena, Cui, Yi, Siederer, Sarah, Parry, Simon, Kenny, Julia, Slack, Robert J., Sahota, Jagdeep, Paul, Lyn, Saunders, Peter, Molyneaux, Philip L., Lukey, Pauline T., Rizzo, Gaia, Searle, Graham E., Marshall, Richard P., Saleem, Azeem, Kang’ombe, Arthur R., Fairman, David, Fahy, William A., Vahdati-Bolouri, Mitra
Publicado 2020

Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis

por John, Alison E., Graves, Rebecca H., Pun, K. Tao, Vitulli, Giovanni, Forty, Ellen J., Mercer, Paul F., Morrell, Josie L., Barrett, John W., Rogers, Rebecca F., Hafeji, Maryam, Bibby, Lloyd I., Gower, Elaine, Morrison, Valerie S., Man, Yim, Roper, James A., Luckett, Jeni C., Borthwick, Lee A., Barksby, Ben S., Burgoyne, Rachel A., Barnes, Rory, Le, Joelle, Flint, David J., Pyne, Susan, Habgood, Anthony, Organ, Louise A., Joseph, Chitra, Edwards-Pritchard, Rochelle C., Maher, Toby M., Fisher, Andrew J., Gudmann, Natasja Stæhr, Leeming, Diana J., Chambers, Rachel C., Lukey, Pauline T., Marshall, Richard P., Macdonald, Simon J. F., Jenkins, R. Gisli, Slack, Robert J.
Publicado 2020