Transforming and evaluating electronic health record disease phenotyping algorithms using the OMOP common data model: a case study in heart failure

por Papez, Vaclav, Moinat, Maxim, Payralbe, Stefan, Asselbergs, Folkert W, Lumbers, R Thomas, Hemingway, Harry, Dobson, Richard, Denaxas, Spiros
Publicado 2021

Translating and evaluating historic phenotyping algorithms using SNOMED CT

por Elkheder, Musaab, Gonzalez-Izquierdo, Arturo, Qummer Ul Arfeen, Muhammad, Kuan, Valerie, Lumbers, R Thomas, Denaxas, Spiros, Shah, Anoop D
Publicado 2022

Type 2 Diabetes, Metabolic Traits, and Risk of Heart Failure: A Mendelian Randomization Study

por Mordi, Ify R., Lumbers, R. Thomas, Palmer, Colin N.A., Pearson, Ewan R., Sattar, Naveed, Holmes, Michael V., Lang, Chim C.
Publicado 2021

Estimating the Effect of Reduced Attendance at Emergency Departments for Suspected Cardiac Conditions on Cardiac Mortality During the COVID-19 Pandemic

por Katsoulis, Michail, Gomes, Manuel, Lai, Alvina G., Henry, Albert, Denaxas, Spiros, Lagiou, Pagona, Nafilyan, Vahe, Humberstone, Ben, Banerjee, Amitava, Hemingway, Harry, Lumbers, R. Thomas
Publicado 2020

Machine learning for subtype definition and risk prediction in heart failure, acute coronary syndromes and atrial fibrillation: systematic review of validity and clinical utility

por Banerjee, Amitava, Chen, Suliang, Fatemifar, Ghazaleh, Zeina, Mohamad, Lumbers, R. Thomas, Mielke, Johanna, Gill, Simrat, Kotecha, Dipak, Freitag, Daniel F., Denaxas, Spiros, Hemingway, Harry
Publicado 2021

A genetic model of ivabradine recapitulates results from randomized clinical trials

por Legault, Marc-André, Sandoval, Johanna, Provost, Sylvie, Barhdadi, Amina, Lemieux Perreault, Louis-Philippe, Shah, Sonia, Lumbers, R. Thomas, de Denus, Simon, Tyl, Benoit, Tardif, Jean-Claude, Dubé, Marie-Pierre
Publicado 2020

Therapeutic Targets for Heart Failure Identified Using Proteomics and Mendelian Randomization

por Henry, Albert, Gordillo-Marañón, María, Finan, Chris, Schmidt, Amand F., Ferreira, João Pedro, Karra, Ravi, Sundström, Johan, Lind, Lars, Ärnlöv, Johan, Zannad, Faiez, Mälarstig, Anders, Hingorani, Aroon D., Lumbers, R. Thomas
Publicado 2022

A population‐based study of 92 clinically recognized risk factors for heart failure: co‐occurrence, prognosis and preventive potential

por Banerjee, Amitava, Pasea, Laura, Chung, Sheng‐Chia, Direk, Kenan, Asselbergs, Folkert W., Grobbee, Diederick E., Kotecha, Dipak, Anker, Stefan D., Dyszynski, Tomasz, Tyl, Benoît, Denaxas, Spiros, Lumbers, R. Thomas, Hemingway, Harry
Publicado 2022

Integrating polygenic risk scores in the prediction of type 2 diabetes risk and subtypes in British Pakistanis and Bangladeshis: A population-based cohort study

por Hodgson, Sam, Huang, Qin Qin, Sallah, Neneh, Griffiths, Chris J., Newman, William G., Trembath, Richard C., Wright, John, Lumbers, R. Thomas, Kuchenbaecker, Karoline, van Heel, David A., Mathur, Rohini, Martin, Hilary C., Finer, Sarah
Publicado 2022

Weight Change and the Onset of Cardiovascular Diseases: Emulating Trials Using Electronic Health Records

por Katsoulis, Michail, Stavola, Bianca D., Diaz-Ordaz, Karla, Gomes, Manuel, Lai, Alvina, Lagiou, Pagona, Wannamethee, Goya, Tsilidis, Konstantinos, Lumbers, R. Thomas, Denaxas, Spiros, Banerjee, Amitava, Parisinos, Constantinos A., Batterham, Rachel, Patel, Riyaz, Langenberg, Claudia, Hemingway, Harry
Publicado 2021

A chronological map of 308 physical and mental health conditions from 4 million individuals in the English National Health Service

por Kuan, Valerie, Denaxas, Spiros, Gonzalez-Izquierdo, Arturo, Direk, Kenan, Bhatti, Osman, Husain, Shanaz, Sutaria, Shailen, Hingorani, Melanie, Nitsch, Dorothea, Parisinos, Constantinos A, Lumbers, R Thomas, Mathur, Rohini, Sofat, Reecha, Casas, Juan P, Wong, Ian C K, Hemingway, Harry, Hingorani, Aroon D
Publicado 2019

The impact of fatty acids biosynthesis on the risk of cardiovascular diseases in Europeans and East Asians: a Mendelian randomization study

por Borges, Maria-Carolina, Haycock, Phillip, Zheng, Jie, Hemani, Gibran, Howe, Laurence J, Schmidt, A Floriaan, Staley, James R, Lumbers, R Thomas, Henry, Albert, Lemaitre, Rozenn N, Gaunt, Tom R, Holmes, Michael V, Davey Smith, George, Hingorani, Aroon D, Lawlor, Deborah A
Publicado 2022

HFrEF subphenotypes based on 4210 repeatedly measured circulating proteins are driven by different biological mechanisms

por Petersen, Teun B., de Bakker, Marie, Asselbergs, Folkert W., Harakalova, Magdalena, Akkerhuis, K. Martijn, Brugts, Jasper J., van Ramshorst, Jan, Lumbers, R. Thomas, Ostroff, Rachel M., Katsikis, Peter D., van der Spek, Peter J., Umans, Victor A., Boersma, Eric, Rizopoulos, Dimitris, Kardys, Isabella
Publicado 2023

Data-driven identification of ageing-related diseases from electronic health records

por Kuan, Valerie, Fraser, Helen C., Hingorani, Melanie, Denaxas, Spiros, Gonzalez-Izquierdo, Arturo, Direk, Kenan, Nitsch, Dorothea, Mathur, Rohini, Parisinos, Constantinos A., Lumbers, R. Thomas, Sofat, Reecha, Wong, Ian C. K., Casas, Juan P., Thornton, Janet M., Hemingway, Harry, Partridge, Linda, Hingorani, Aroon D.
Publicado 2021

Genetic and environmental determinants of diastolic heart function

por Thanaj, Marjola, Mielke, Johanna, McGurk, Kathryn A., Bai, Wenjia, Savioli, Nicolò, de Marvao, Antonio, Meyer, Hannah V., Zeng, Lingyao, Sohler, Florian, Lumbers, R. Thomas, Wilkins, Martin R., Ware, James S., Bender, Christian, Rueckert, Daniel, MacNamara, Aidan, Freitag, Daniel F., O’Regan, Declan P.
Publicado 2022

Identifying adults at high-risk for change in weight and BMI in England: a longitudinal, large-scale, population-based cohort study using electronic health records

por Katsoulis, Michail, Lai, Alvina G, Diaz-Ordaz, Karla, Gomes, Manuel, Pasea, Laura, Banerjee, Amitava, Denaxas, Spiros, Tsilidis, Kostas, Lagiou, Pagona, Misirli, Gesthimani, Bhaskaran, Krishnan, Wannamethee, Goya, Dobson, Richard, Batterham, Rachel L, Kipourou, Dimitra-Kleio, Lumbers, R Thomas, Wen, Lan, Wareham, Nick, Langenberg, Claudia, Hemingway, Harry
Publicado 2021

Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals

por Huang, Qin Qin, Sallah, Neneh, Dunca, Diana, Trivedi, Bhavi, Hunt, Karen A., Hodgson, Sam, Lambert, Samuel A., Arciero, Elena, Wright, John, Griffiths, Chris, Trembath, Richard C., Hemingway, Harry, Inouye, Michael, Finer, Sarah, van Heel, David A., Lumbers, R. Thomas, Martin, Hilary C., Kuchenbaecker, Karoline
Publicado 2022

PDGFRα demarcates the cardiogenic clonogenic Sca1(+) stem/progenitor cell in adult murine myocardium

por Noseda, Michela, Harada, Mutsuo, McSweeney, Sara, Leja, Thomas, Belian, Elisa, Stuckey, Daniel J., Abreu Paiva, Marta S., Habib, Josef, Macaulay, Iain, de Smith, Adam J., al-Beidh, Farah, Sampson, Robert, Lumbers, R. Thomas, Rao, Pulivarthi, Harding, Sian E., Blakemore, Alexandra I. F., Eirik Jacobsen, Sten, Barahona, Mauricio, Schneider, Michael D.
Publicado 2015

H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts

por Pei, Jiayi, Harakalova, Magdalena, Treibel, Thomas A., Lumbers, R Thomas, Boukens, Bastiaan J., Efimov, Igor R., van Dinter, Jip T., González, Arantxa, López, Begoña, El Azzouzi, Hamid, van den Dungen, Noortje, van Dijk, Christian G. M., Krebber, Merle M., den Ruijter, Hester M., Pasterkamp, Gerard, Duncker, Dirk J., Nieuwenhuis, Edward E. S., de Weger, Roel, Huibers, Manon M., Vink, Aryan, Moore, Jason H., Moon, James C., Verhaar, Marianne C., Kararigas, Georgios, Mokry, Michal, Asselbergs, Folkert W., Cheng, Caroline
Publicado 2020

Evidence-Based Assessment of Genes in Dilated Cardiomyopathy

por Jordan, Elizabeth, Peterson, Laiken, Ai, Tomohiko, Asatryan, Babken, Bronicki, Lucas, Brown, Emily, Celeghin, Rudy, Edwards, Matthew, Fan, Judy, Ingles, Jodie, James, Cynthia A., Jarinova, Olga, Johnson, Renee, Judge, Daniel P., Lahrouchi, Najim, Lekanne Deprez, Ronald H., Lumbers, R. Thomas, Mazzarotto, Francesco, Medeiros Domingo, Argelia, Miller, Rebecca L., Morales, Ana, Murray, Brittney, Peters, Stacey, Pilichou, Kalliopi, Protonotarios, Alexandros, Semsarian, Christopher, Shah, Palak, Syrris, Petros, Thaxton, Courtney, van Tintelen, J. Peter, Walsh, Roddy, Wang, Jessica, Ware, James, Hershberger, Ray E.
Publicado 2021