Oligonucleotide Therapies: The Past and the Present

por Lundin, Karin E., Gissberg, Olof, Smith, C.I. Edvard
Publicado 2015

Oligonucleotide–Palladacycle Conjugates as Splice-Correcting Agents

por Hande, Madhuri, Saher, Osama, Lundin, Karin E., Smith, C. I. Edvard, Zain, Rula, Lönnberg, Tuomas
Publicado 2019

A synthetic snRNA m(3)G-CAP enhances nuclear delivery of exogenous proteins and nucleic acids

por Moreno, Pedro M. D., Wenska, Malgorzata, Lundin, Karin E., Wrange, Örjan, Strömberg, Roger, Smith, C. I. Edvard
Publicado 2009

Oligonucleotide Binding to Non-B-DNA in MYC

por Umek, Tea, Sollander, Karin, Bergquist, Helen, Wengel, Jesper, Lundin, Karin E., Smith, C.I. Edvard, Zain, Rula
Publicado 2019

The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study

por Xu, You, Gissberg, Olof, Pabon-Martinez, Y. Vladimir, Wengel, Jesper, Lundin, Karin E., Smith, C. I. Edvard, Zain, Rula, Nilsson, Lennart, Villa, Alessandra
Publicado 2019

Role of Pseudoisocytidine Tautomerization in Triplex-Forming Oligonucleotides: In Silico and in Vitro Studies

por Hartono, Yossa Dwi, Pabon-Martinez, Y. Vladimir, Uyar, Arzu, Wengel, Jesper, Lundin, Karin E., Zain, Rula, Smith, C. I. Edvard, Nilsson, Lennart, Villa, Alessandra
Publicado 2017

Eleven percent intact PGM3 in a severely immunodeficient patient with a novel splice-site mutation, a case report

por Lundin, Karin E., Wang, Qing, Hamasy, Abdulrahman, Marits, Per, Uzunel, Mehmet, Wirta, Valtteri, Wikström, Ann-Charlotte, Fasth, Anders, Ekwall, Olov, Smith, C.I. Edvard
Publicado 2018

Sugar and Polymer Excipients Enhance Uptake and Splice-Switching Activity of Peptide-Dendrimer/Lipid/Oligonucleotide Formulations

por Saher, Osama, Lehto, Taavi, Gissberg, Olof, Gupta, Dhanu, Gustafsson, Oskar, Andaloussi, Samir EL, Darbre, Tamis, Lundin, Karin E., Smith, C. I. Edvard, Zain, Rula
Publicado 2019

Repeatable, Inducible Micro-RNA-Based Technology Tightly Controls Liver Transgene Expression

por Oprea, Iulian I, Viola, Joana R, Moreno, Pedro M D, Simonson, Oscar E, Rodin, Sergey, Teller, Nathalie, Tryggvason, Karl, Lundin, Karin E, Girnita, Leonard, Smith, Carl Inge Edvard
Publicado 2014

CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression

por Zaghloul, Eman M., Gissberg, Olof, Moreno, Pedro M.D., Siggens, Lee, Hällbrink, Mattias, Jørgensen, Anna S., Ekwall, Karl, Zain, Rula, Wengel, Jesper, Lundin, Karin E., Smith, C.I. Edvard
Publicado 2017

Oligonucleotides Targeting DNA Repeats Downregulate Huntingtin Gene Expression in Huntington's Patient-Derived Neural Model System

por Umek, Tea, Olsson, Thomas, Gissberg, Olof, Saher, Osama, Zaghloul, Eman M., Lundin, Karin E., Wengel, Jesper, Hanse, Eric, Zetterberg, Henrik, Vizlin-Hodzic, Dzeneta, Smith, C. I. Edvard, Zain, Rula
Publicado 2021

2′-O-(N-(Aminoethyl)carbamoyl)methyl Modification Allows for Lower Phosphorothioate Content in Splice-Switching Oligonucleotides with Retained Activity

por Honcharenko, Dmytro, Rocha, Cristina S.J., Lundin, Karin E., Maity, Jyotirmoy, Milton, Stefan, Tedebark, Ulf, Murtola, Merita, Honcharenko, Malgorzata, Slaitas, Andis, Smith, C.I. Edvard, Zain, Rula, Strömberg, Roger
Publicado 2022

Chemical Modifications and Design Influence the Potency of Huntingtin Anti-Gene Oligonucleotides

por Saher, Osama, Zaghloul, Eman M., Umek, Tea, Hagey, Daniel W., Mozafari, Negin, Danielsen, Mathias B., Gouda, Alaa S., Lundin, Karin E., Jørgensen, Per T., Wengel, Jesper, Smith, C.I. Edvard, Zain, Rula
Publicado 2023

Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides

por Daralnakhla, Haneen, Saher, Osama, Zamolo, Susanna, Bazaz, Safa, P. Bost, Jeremy, Heitz, Marc, Lundin, Karin E., EL Andaloussi, Samir, Darbre, Tamis, Reymond, Jean-Louis, Zain, Rula, Smith, C. I. Edvard
Publicado 2021

Optimizing anti-gene oligonucleotide ‘Zorro-LNA’ for improved strand invasion into duplex DNA

por Zaghloul, Eman M., Madsen, Andreas S., Moreno, Pedro M. D., Oprea, Iulian I., El-Andaloussi, Samir, Bestas, Burcu, Gupta, Pankaj, Pedersen, Erik B., Lundin, Karin E., Wengel, Jesper, Smith, C. I. Edvard
Publicado 2011

Micro-minicircle Gene Therapy: Implications of Size on Fermentation, Complexation, Shearing Resistance, and Expression

por Stenler, Sofia, Wiklander, Oscar PB, Badal-Tejedor, Maria, Turunen, Janne, Nordin, Joel Z, Hallengärd, David, Wahren, Britta, Andaloussi, Samir EL, Rutland, Mark W, Smith, CI Edvard, Lundin, Karin E, Blomberg, Pontus
Publicado 2014

LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures

por Pabon-Martinez, Y. Vladimir, Xu, You, Villa, Alessandra, Lundin, Karin E., Geny, Sylvain, Nguyen, Chi-Hung, Pedersen, Erik B., Jørgensen, Per T., Wengel, Jesper, Nilsson, Lennart, Smith, C. I. Edvard, Zain, Rula
Publicado 2017

Susceptibility to infections, without concomitant hyper-IgE, reported in 1976, is caused by hypomorphic mutation in the phosphoglucomutase 3 (PGM3) gene

por Lundin, Karin E., Hamasy, Abdulrahman, Backe, Paul Hoff, Moens, Lotte N., Falk-Sörqvist, Elin, Elgstøen, Katja B., Mørkrid, Lars, Bjørås, Magnar, Granert, Carl, Norlin, Anna-Carin, Nilsson, Mats, Christensson, Birger, Stenmark, Stephan, Smith, C.I. Edvard
Publicado 2015

Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA

por Moreno, Pedro M. D., Geny, Sylvain, Pabon, Y. Vladimir, Bergquist, Helen, Zaghloul, Eman M., Rocha, Cristina S. J., Oprea, Iulian I., Bestas, Burcu, Andaloussi, Samir EL, Jørgensen, Per T., Pedersen, Erik B., Lundin, Karin E., Zain, Rula, Wengel, Jesper, Smith, C. I. Edvard
Publicado 2013

Next-generation bis-locked nucleic acids with stacking linker and 2′-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes

por Geny, Sylvain, Moreno, Pedro M. D., Krzywkowski, Tomasz, Gissberg, Olof, Andersen, Nicolai K., Isse, Abdirisaq J., El-Madani, Amro M., Lou, Chenguang, Pabon, Y. Vladimir, Anderson, Brooke A., Zaghloul, Eman M., Zain, Rula, Hrdlicka, Patrick J., Jørgensen, Per T., Nilsson, Mats, Lundin, Karin E., Pedersen, Erik B., Wengel, Jesper, Smith, C. I. Edvard
Publicado 2016