Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery

por Luth, Madeline R., Gupta, Purva, Ottilie, Sabine, Winzeler, Elizabeth A.
Publicado 2018

CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM)

por Debnath, Anjan, Calvet, Claudia M., Jennings, Gareth, Zhou, Wenxu, Aksenov, Alexander, Luth, Madeline R., Abagyan, Ruben, Nes, W. David, McKerrow, James H., Podust, Larissa M.
Publicado 2017

Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance

por Mandt, Rebecca EK, Luth, Madeline R, Tye, Mark A, Mazitschek, Ralph, Ottilie, Sabine, Winzeler, Elizabeth A, Lafuente-Monasterio, Maria Jose, Gamo, Francisco Javier, Wirth, Dyann F, Lukens, Amanda K
Publicado 2023

Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents

por Stokes, Barbara H., Yoo, Euna, Murithi, James M., Luth, Madeline R., Afanasyev, Pavel, da Fonseca, Paula C. A., Winzeler, Elizabeth A., Ng, Caroline L., Bogyo, Matthew, Fidock, David A.
Publicado 2019

PfMFR3: A Multidrug-Resistant Modulator in Plasmodium falciparum

por Rocamora, Frances, Gupta, Purva, Istvan, Eva S., Luth, Madeline R., Carpenter, Emma F., Kümpornsin, Krittikorn, Sasaki, Erika, Calla, Jaeson, Mittal, Nimisha, Carolino, Krypton, Owen, Edward, Llinás, Manuel, Ottilie, Sabine, Goldberg, Daniel E., Lee, Marcus C. S., Winzeler, Elizabeth A.
Publicado 2021

Probing the Open Global Health Chemical Diversity Library for Multistage-Active Starting Points for Next-Generation Antimalarials

por Abraham, Matthew, Gagaring, Kerstin, Martino, Marisa L., Vanaerschot, Manu, Plouffe, David M., Calla, Jaeson, Godinez-Macias, Karla P., Du, Alan Y., Wree, Melanie, Antonova-Koch, Yevgeniya, Eribez, Korina, Luth, Madeline R., Ottilie, Sabine, Fidock, David A., McNamara, Case W., Winzeler, Elizabeth A.
Publicado 2020

Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance

por Tye, Mark A., Payne, N. Connor, Johansson, Catrine, Singh, Kritika, Santos, Sofia A., Fagbami, Lọla, Pant, Akansha, Sylvester, Kayla, Luth, Madeline R., Marques, Sofia, Whitman, Malcolm, Mota, Maria M., Winzeler, Elizabeth A., Lukens, Amanda K., Derbyshire, Emily R., Oppermann, Udo, Wirth, Dyann F., Mazitschek, Ralph
Publicado 2022

Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome

por Xie, Stanley C., Gillett, David L., Spillman, Natalie J., Tsu, Christopher, Luth, Madeline R., Ottilie, Sabine, Duffy, Sandra, Gould, Alexandra E., Hales, Paul, Seager, Benjamin A., Charron, Carlie L., Bruzzese, Frank, Yang, Xiaofeng, Zhao, Xiansi, Huang, Shih-Chung, Hutton, Craig A., Burrows, Jeremy N., Winzeler, Elizabeth A., Avery, Vicky M., Dick, Lawrence R., Tilley, Leann
Publicado 2018

Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum

por Kümpornsin, Krittikorn, Kochakarn, Theerarat, Yeo, Tomas, Okombo, John, Luth, Madeline R., Hoshizaki, Johanna, Rawat, Mukul, Pearson, Richard D., Schindler, Kyra A., Mok, Sachel, Park, Heekuk, Uhlemann, Anne-Catrin, Jana, Gouranga P., Maity, Bikash C., Laleu, Benoît, Chenu, Elodie, Duffy, James, Moliner Cubel, Sonia, Franco, Virginia, Gomez-Lorenzo, Maria G., Gamo, Francisco Javier, Winzeler, Elizabeth A., Fidock, David A., Chookajorn, Thanat, Lee, Marcus C. S.
Publicado 2023

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

por LaMonte, Gregory M., Rocamora, Frances, Marapana, Danushka S., Gnädig, Nina F., Ottilie, Sabine, Luth, Madeline R., Worgall, Tilla S., Goldgof, Gregory M., Mohunlal, Roxanne, Santha Kumar, T. R., Thompson, Jennifer K., Vigil, Edgar, Yang, Jennifer, Hutson, Dylan, Johnson, Trevor, Huang, Jianbo, Williams, Roy M., Zou, Bing Yu, Cheung, Andrea L., Kumar, Prianka, Egan, Timothy J., Lee, Marcus C. S., Siegel, Dionicio, Cowman, Alan F., Fidock, David A., Winzeler, Elizabeth A.
Publicado 2020

Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance

por Ottilie, Sabine, Luth, Madeline R., Hellemann, Erich, Goldgof, Gregory M., Vigil, Eddy, Kumar, Prianka, Cheung, Andrea L., Song, Miranda, Godinez-Macias, Karla P., Carolino, Krypton, Yang, Jennifer, Lopez, Gisel, Abraham, Matthew, Tarsio, Maureen, LeBlanc, Emmanuelle, Whitesell, Luke, Schenken, Jake, Gunawan, Felicia, Patel, Reysha, Smith, Joshua, Love, Melissa S., Williams, Roy M., McNamara, Case W., Gerwick, William H., Ideker, Trey, Suzuki, Yo, Wirth, Dyann F., Lukens, Amanda K., Kane, Patricia M., Cowen, Leah E., Durrant, Jacob D., Winzeler, Elizabeth A.
Publicado 2022

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

por Antonova-Koch, Yevgeniya, Meister, Stephan, Abraham, Matthew, Luth, Madeline R., Ottilie, Sabine, Lukens, Amanda K., Sakata-Kato, Tomoyo, Vanaerschot, Manu, Owen, Edward, Jado, Juan Carlos, Maher, Steven P., Calla, Jaeson, Plouffe, David, Zhong, Yang, Chen, Kaisheng, Chaumeau, Victor, Conway, Amy J., McNamara, Case W., Ibanez, Maureen, Gagaring, Kerstin, Serrano, Fernando Neria, Eribez, Korina, Taggard, Cullin McLean, Cheung, Andrea L., Lincoln, Christie, Ambachew, Biniam, Rouillier, Melanie, Siegel, Dionicio, Nosten, François, Kyle, Dennis E., Gamo, Francisco-Javier, Zhou, Yingyao, Llinás, Manuel, Fidock, David A., Wirth, Dyann F., Burrows, Jeremy, Campo, Brice, Winzeler, Elizabeth A.
Publicado 2018

Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention

por Summers, Robert L., Pasaje, Charisse Flerida A., Pisco, Joao P., Striepen, Josefine, Luth, Madeline R., Kumpornsin, Krittikorn, Carpenter, Emma F., Munro, Justin T., Lin, De, Plater, Andrew, Punekar, Avinash S., Shepherd, Andrew M., Shepherd, Sharon M., Vanaerschot, Manu, Murithi, James M., Rubiano, Kelly, Akidil, Aslı, Ottilie, Sabine, Mittal, Nimisha, Dilmore, A. Hazel, Won, Madalyn, Mandt, Rebecca E.K., McGowen, Kerry, Owen, Edward, Walpole, Chris, Llinás, Manuel, Lee, Marcus C.S., Winzeler, Elizabeth A., Fidock, David A., Gilbert, Ian H., Wirth, Dyann F., Niles, Jacquin C., Baragaña, Beatriz, Lukens, Amanda K.
Publicado 2022

Reaction hijacking of tyrosine tRNA synthetase as a whole-of-life-cycle antimalarial strategy

por Xie, Stanley C., Metcalfe, Riley D., Dunn, Elyse, Morton, Craig J., Huang, Shih-Chung, Puhalovich, Tanya, Du, Yawei, Wittlin, Sergio, Nie, Shuai, Luth, Madeline R., Ma, Liting, Kim, Mi-Sook, Pasaje, Charisse Flerida A., Kumpornsin, Krittikorn, Giannangelo, Carlo, Houghton, Fiona J., Churchyard, Alisje, Famodimu, Mufuliat T., Barry, Daniel C., Gillett, David L., Dey, Sumanta, Kosasih, Clara C., Newman, William, Niles, Jacquin C., Lee, Marcus C.S., Baum, Jake, Ottilie, Sabine, Winzeler, Elizabeth A., Creek, Darren J., Williamson, Nicholas, Parker, Michael W., Brand, Stephen L., Langston, Steven P., Dick, Lawrence R., Griffin, Michael D.W., Gould, Alexandra E., Tilley, Leann
Publicado 2022

Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase

por Xie, Stanley C., Wang, Yinuo, Morton, Craig J., Metcalfe, Riley D., Dogovski, Con, Pasaje, Charisse Flerida A., Dunn, Elyse, Luth, Madeline R, Kumpornsin, Krittikorn, Istvan, Eva S, Park, Joon Sung, Fairhurst, Kate J., Ketprasit, Nutpakal, Yeo, Tomas, Yildirim, Okan, Bhebhe, Mathamsanqa N., Klug, Dana M., Rutledge, Peter J., Godoy, Luiz C., Dey, Sumanta, De Souza, Mariana Laureano, Siqueira-Neto, Jair L., Du, Yawei, Puhalovich, Tanya, Amini, Mona, Shami, Gerry, Loesbanluechai, Duangkamon, Nie, Shuai, Williamson, Nicholas, Jana, Gouranga P., Maity, Bikash C., Thomson, Patrick, Foley, Thomas, Tan, Derek S., Niles, Jacquin C, Han, Byung Woo, Goldberg, Daniel E, Burrows, Jeremy, Fidock, David A., Lee, Marcus C.S., Winzeler, Elizabeth A., Griffin, Michael D. W., Todd, Matthew H., Tilley, Leann
Publicado 2023