Intratumoral nanobody–IL-2 fusions that bind the tumor extracellular matrix suppress solid tumor growth in mice

por Lutz, Emi A, Jailkhani, Noor, Momin, Noor, Huang, Ying, Sheen, Allison, Kang, Byong H, Wittrup, K Dane, Hynes, Richard O
Publicado 2022

An affinity threshold for maximum efficacy in anti-PD-1 immunotherapy

por Cowles, Sarah C., Sheen, Allison, Santollani, Luciano, Lutz, Emi A., Lax, Brianna M., Palmeri, Joseph R., Freeman, Gordon J., Wittrup, K. Dane
Publicado 2022

Tregs constrain CD8(+) T cell priming required for curative intratumorally anchored anti-4-1BB immunotherapy

por Palmeri, Joseph R., Lax, Brianna M., Peters, Joshua M., Duhamel, Lauren, Stinson, Jordan A., Santollani, Luciano, Lutz, Emi A., Pinney, William, Bryson, Bryan D., Wittrup, K. Dane
Publicado 2023

Enhanced Vaccine Immunogenicity Enabled by Targeted Cytosolic Delivery of Tumor Antigens into Dendritic Cells

por Truex, Nicholas L., Rondon, Aurélie, Rössler, Simon L., Hanna, Cameron C., Cho, Yehlin, Wang, Bin-You, Backlund, Coralie M., Lutz, Emi A., Irvine, Darrell J., Pentelute, Bradley L.
Publicado 2023

Maximizing response to intratumoral immunotherapy in mice by tuning local retention

por Momin, Noor, Palmeri, Joseph R., Lutz, Emi A., Jailkhani, Noor, Mak, Howard, Tabet, Anthony, Chinn, Magnolia M., Kang, Byong H., Spanoudaki, Virginia, Hynes, Richard O., Wittrup, K. Dane
Publicado 2022

Alum-anchored intratumoral retention improves the tolerability and antitumor efficacy of type I interferon therapies

por Lutz, Emi A., Agarwal, Yash, Momin, Noor, Cowles, Sarah C., Palmeri, Joseph R., Duong, Ellen, Hornet, Vladlena, Sheen, Allison, Lax, Brianna M., Rothschilds, Adrienne M., Irvine, Darrell J., Spranger, Stefani, Wittrup, K. Dane
Publicado 2022

Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity

por Agarwal, Yash, Milling, Lauren E., Chang, Jason Y.H., Santollani, Luciano, Sheen, Allison, Lutz, Emi A., Tabet, Anthony, Stinson, Jordan, Ni, Kaiyuan, Rodrigues, Kristen A., Moyer, Tyson J., Melo, Mariane B., Irvine, Darrell J., Wittrup, K. Dane
Publicado 2022