Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin

por Lynagh, Timothy, Lynch, Joseph W.
Publicado 2012

The impact of human hyperekplexia mutations on glycine receptor structure and function

por Bode, Anna, Lynch, Joseph W
Publicado 2014

Functional characterization of ivermectin binding sites in α1β2γ2L GABA(A) receptors

por Estrada-Mondragon, Argel, Lynch, Joseph W.
Publicado 2015

β Subunit M2–M3 Loop Conformational Changes Are Uncoupled from α1 β Glycine Receptor Channel Gating: Implications for Human Hereditary Hyperekplexia

por Shan, Qiang, Han, Lu, Lynch, Joseph W.
Publicado 2011

The Free Zinc Concentration in the Synaptic Cleft of Artificial Glycinergic Synapses Rises to At least 1 μM

por Zhang, Yan, Keramidas, Angelo, Lynch, Joseph W.
Publicado 2016

Fluorescence-Based High-Throughput Functional Profiling of Ligand-Gated Ion Channels at the Level of Single Cells

por Talwar, Sahil, Lynch, Joseph W., Gilbert, Daniel F.
Publicado 2013

Generation of Functional Inhibitory Synapses Incorporating Defined Combinations of GABA(A) or Glycine Receptor Subunits

por Dixon, Christine L., Zhang, Yan, Lynch, Joseph W.
Publicado 2015

SAHA (Vorinostat) Corrects Inhibitory Synaptic Deficits Caused by Missense Epilepsy Mutations to the GABA(A) Receptor γ2 Subunit

por Durisic, Nela, Keramidas, Angelo, Dixon, Christine L., Lynch, Joseph W.
Publicado 2018

γ1-Containing GABA-A Receptors Cluster at Synapses Where they Mediate Slower Synaptic Currents than γ2-Containing GABA-A Receptors

por Dixon, Christine L., Sah, Pankaj, Keramidas, Angelo, Lynch, Joseph W., Durisic, Nela
Publicado 2017

Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortus

por Atif, Mohammed, Estrada-Mondragon, Argel, Nguyen, Bindi, Lynch, Joseph W., Keramidas, Angelo
Publicado 2017

Effects of GABA(A) Receptor α3 Subunit Epilepsy Mutations on Inhibitory Synaptic Signaling

por Syed, Parnayan, Durisic, Nela, Harvey, Robert J., Sah, Pankaj, Lynch, Joseph W.
Publicado 2020

High Throughput Techniques for Discovering New Glycine Receptor Modulators and their Binding Sites

por Gilbert, Daniel F., Islam, Robiul, Lynagh, Timothy, Lynch, Joseph W., Webb, Timothy I.
Publicado 2009

Structure-Function Analysis of the GlyR α2 Subunit Autism Mutation p.R323L Reveals a Gain-of-Function

por Zhang, Yan, Ho, Thi Nhu Thao, Harvey, Robert J., Lynch, Joseph W., Keramidas, Angelo
Publicado 2017

Structure/Function Studies of the α4 Subunit Reveal Evolutionary Loss of a GlyR Subtype Involved in Startle and Escape Responses

por Leacock, Sophie, Syed, Parnayan, James, Victoria M., Bode, Anna, Kawakami, Koichi, Keramidas, Angelo, Suster, Maximiliano, Lynch, Joseph W., Harvey, Robert J.
Publicado 2018

GluClR-mediated inhibitory postsynaptic currents reveal targets for ivermectin and potential mechanisms of ivermectin resistance

por Atif, Mohammed, Smith, Jennifer J., Estrada-Mondragon, Argel, Xiao, Xue, Salim, Angela A., Capon, Robert J., Lynch, Joseph W., Keramidas, Angelo
Publicado 2019

Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABA(A) receptors

por Wang, Meng, Cotter, Edmund, Wang, Ya-Juan, Fu, Xu, Whittsette, Angela L., Lynch, Joseph W., Wiseman, R. Luke, Kelly, Jeffery W., Keramidas, Angelo, Mu, Ting-Wei
Publicado 2022

Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels

por Cristofori-Armstrong, Ben, Soh, Ming S., Talwar, Sahil, Brown, Darren L., Griffin, John D. O., Dekan, Zoltan, Stow, Jennifer L., King, Glenn F., Lynch, Joseph W., Rash, Lachlan D.
Publicado 2015

Loss, Gain and Altered Function of GlyR α2 Subunit Mutations in Neurodevelopmental Disorders

por Chen, Xiumin, Wilson, Katie A., Schaefer, Natascha, De Hayr, Lachlan, Windsor, Mark, Scalais, Emmanuel, van Rijckevorsel, Germaine, Stouffs, Katrien, Villmann, Carmen, O’Mara, Megan L., Lynch, Joseph W., Harvey, Robert J.
Publicado 2022

Novel missense mutations in the glycine receptor β subunit gene (GLRB) in startle disease

por James, Victoria M., Bode, Anna, Chung, Seo-Kyung, Gill, Jennifer L., Nielsen, Maartje, Cowan, Frances M., Vujic, Mihailo, Thomas, Rhys H., Rees, Mark I., Harvey, Kirsten, Keramidas, Angelo, Topf, Maya, Ginjaar, Ieke, Lynch, Joseph W., Harvey, Robert J.
Publicado 2013

Disruption of a Structurally Important Extracellular Element in the Glycine Receptor Leads to Decreased Synaptic Integration and Signaling Resulting in Severe Startle Disease

por Schaefer, Natascha, Berger, Alexandra, van Brederode, Johannes, Zheng, Fang, Zhang, Yan, Leacock, Sophie, Littau, Laura, Jablonka, Sibylle, Malhotra, Sony, Topf, Maya, Winter, Friederike, Davydova, Daria, Lynch, Joseph W., Paige, Christopher J., Alzheimer, Christian, Harvey, Robert J., Villmann, Carmen
Publicado 2017